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Progress in Chemistry 2023, Vol. 35 Issue (4): 519-525 DOI: 10.7536/PC221001 Previous Articles   Next Articles

• Review •

Fabrication and Biomedical Application of Hyaluronic Acid Based Micro- and Nanogels

Xuedan Qian(), Weijiang Yu, Junzhe Fu, Youxiang Wang, Jian Ji   

  1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027, China
  • Received: Revised: Online: Published:
  • Contact: *e-mail:yx_wang@zju.edu.cn
  • Supported by:
    National Key Research and Development Project(2020YFE0204400); National Natural Science Foundation of China(51873186)
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Hyaluronic acid is one of the primary components of the natural extracellular matrix, which has outstanding biocompatibility, biodegradability and excellent water retention capacity. Hyaluronic acid based micro- and nanogels have many desirable features of size adjustability, easy modification, deformability and structural integrity. They can not only meet most application requirements of bulk hydrogels, but also possess unique advantages due to small dimension, thus have been widely researched and used in biomedical field. This paper reviews the preparation methods and biomedical applications of hyaluronic acid based micro- and nanogels, and the future development of it is prospected.

Key words: hyaluronic acid, micro- and nanogels, crosslinking modification, biomedical application
Fig.1 Schematic illustration of cisplatin/doxorubicin co-loaded crosslinked HA nanogels[27]
Fig.2 Representative scheme of preparation of HA nanogels for image-guided combined chemo and photodynamic therapy[38]
Fig.3 Schematics of preparation of microgel/hydrogel composites[43]
Fig.4 Bioink assembled by microgels[48]
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