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Progress in Chemistry 2021, Vol. 33 Issue (6): 1035-1043 DOI: 10.7536/PC200659 Previous Articles   Next Articles

• Review •

Application of Small-Molecule Fluorescent Probes in the Development of Green Pesticides

Xiaohan Hou1, Shengnan Liu1,2,*(), Qingzhi Gao1,*()   

  1. 1 School of Pharmaceutical Science and Technology, Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Tianjin University, Tianjin 300072, China
    2 Institute of Molecular Plus, Tianjin University,Tianjin 300072, China
  • Received: Revised: Online: Published:
  • Contact: Shengnan Liu, Qingzhi Gao
  • About author:
    * Corresponding author e-mail: (Shengnan Liu);
    (Qingzhi Gao)
  • Supported by:
    National Key Research and Development Project(2017YFD0201403)
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Small-molecule fluorescent probes are widely applied in the fields of life science, medicinal chemistry and environmental science, due to their characteristics of high sensitivity and specificity, good stability and economic applicability. In pesticide chemistry, small-molecule fluorescent probes are frequently utilized in the detection of pesticide residues and heavy metal pollutions. With global strategic needs and rapid technological progress in green pesticide development, fluorescent probes are urgently desired as important molecular tools for design, screening and development of environmentally benign agrichemicals. This article aims to review the key updates of small-molecule fluorescent bioprobes in green pesticide R&D by covering their chemical design, molecular targeting, and screening mechanisms against different green pesticide biotargets, and to provide the current status on their research and application as well as future perspectives.

Contents

1 Introduction

2 Ryanodine receptor-targeted small-molecule fluorescent probes

2.1 Anthranilic diamide-based fluorescent probes

2.2 Phthalic diamide-based fluorescent probes

3 Chitin-targeted small molecule fluorescent probes

3.1 Chitin synthase-targeted fluorescent probes

3.2 Chitin related enzyme-targeted fluorescent probes

4 Type Ⅲ secretion system-targeted small-molecule fluorescent probes

5 γ-Aminobutyric acid receptor-targeted small-molecule fluorescent pesticides

6 Acetohydroxyacid synthase-targeted small-molecule fluorescent probes

7 Conclusion and outlook

Key words: small-molecule fluorescent probe, green pesticides, ryanodine receptor, chitin synthase, high-throughput screening
Fig.1 (a) Design concept of RyR-targeted specific fluorescent probe.(b) Different binding location of ChloF and Ryanodine in RyR
Fig.2 RyR-targeted fluorescent probe based on Flu for in vitro and in vivo imaging studies[28]
Fig.3 RyR-targeted NIR fluorescent probe based on Flu[29]
Fig.4 (a) CHS catalyzed chitin synthesis.(b) Traditional radio-labeled substrate and the fluorescent probe[38]
Fig.5 (a) Traditional chitinase fluorescent substrates.(b) Hexosaminidase selective fluorescent probe[41]
Fig.6 (a) T3SS-targeted specific fluorescence probe.(b) Glu-CyFur reporter system for high-throughput screening[51⇓⇓~54]
Fig.7 (a) Fipronil-based fluorescent phloem-mobile insecticides.(b) Mechanism of fluorescent PAs insecticides[60]
Fig.8 New AHAS inhibitor screening method based on aldehyde-containing fluorescent probe 1[80]
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