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Progress in Chemistry 2020, Vol. 32 Issue (8): 1128-1139 DOI: 10.7536/PC200432 Previous Articles   Next Articles

• Review •

Regulation of Condensed States of Biological Macromolecules by Rationally Designed Nanomaterials

Qiao Jiang1, Xuehui Xu1, Baoquan Ding1,**()   

  1. 1. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
  • Received: Revised: Online: Published:
  • Contact: Baoquan Ding
  • About author:
    ** e-mail:
  • Supported by:
    the National Natural Science Foundation of China(31700871)
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The condensed states of biological macromolecules and their dynamic changes are related to many important physiological and pathological processes, such as coagulation and Alzheimer’s disease. Study of these processes is essential for patients with coagulation-associated diseases or Alzheimer’s disease. The development of effective regulating agents capable of interacting with such biomolecules has been suggested as a solution for diagnosis and therapy. The application of nanotechnology to medicine enable the design and fabrication of novel functional nanomaterials for disease treatment. In this review, we summarize the recent successful efforts to employ functional nanomaterials for regulating coagulation(triggering tumor vessel occlusion or fabricating nanoanticoagulants) and altering the aggregation and clearance of amyloid-β(Aβ). The remaining challenges and open opportunities are also discussed.

Contents

1 Physiological and pathological phenomenon of biomacromolecule aggregation

1.1 Blood coagulation

1.2 Alzheimer’s disease(AD)

2 Nanomaterials

2.1 Gold nanoparticles

2.2 Polymeric nanoparticles

2.3 DNA/RNA nanostructures

2.4 Peptide-based nanomaterials

3 Regulation of condensed states of biological macromolecules by nanomaterials

3.1 Nanomaterials for tumor infarction and therapy

3.2 Nano-anticoagulants

3.3 Nanomaterials for AD diagnosis and therapy

4 Conclusion and outlook

Key words: nanomaterials, biological macromolecules, condensed states, coagulation, Alzheimer’s disease
Fig.1 Coagulation process
Fig.2 The amyloid hypothesis
Fig.3 Design of thrombin-functionalized DNA nanorobot[29]. Copyright 2018, Nature Publishing Group
Fig.4 Nano-anticoagulants.(A) Thrombin Inhibition by the MB/AuNRs-Closed-Loop Structure [34]. Copyright 2015, American Chemical Society.(B) Self-assembled DAPA-NPs and the thrombin inhibition[37]. Copyright 2017, American Chemical Society
Fig.5 Nanomaterials for Aβ regulation and clearance.(A) Enhanced binding of Aβ with βCas promoted by the AuNP substrate[41]. Copyright 2019, Nature Publishing Group.(B) Peptide nanoparticle captures Aβ by hydrogen-bonded co-assembly and internalizes a substantial amount into cells carrying Aβ[42]. Copyright 2018, Nature Publishing Group
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