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Progress in Chemistry 2020, Vol. 32 Issue (4): 497-504 DOI: 10.7536/PC190816 Previous Articles   

Application of Metal-Organic Framework Materials in Enrichment of Active Peptides

Peng Ning, Yunhui Cheng, Zhou Xu, Li Ding, Maolong Chen*()   

  1. College of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, China
  • Received: Revised: Online: Published:
  • Contact: Maolong Chen
  • Supported by:
    The work was supported by the National Key Research and Development Project of China(2018YFD0400405); the Hunan Natural Science Foundation Project(2019JJ50638)
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Bioactive peptides play an important role in physiological processes. Accurate analysis of bioactive peptides will help to further develop their efficacy. Due to the bioactive peptides often coexisting with high concentrations of proteins, it is still quite difficult to analyze peptides in complex biological systems. These coexisted proteins may severely reduce the separation efficiency of chromatographic column for bioactive peptides and inhibit the peak signal of the peptide in the mass spectrum. In view of this, metal-organic frameworks are introduced to perform enrichment analysis of active peptides. Metal-organic frameworks(MOFs) is a type of framework self-assembled by coordination bonds between metal ions or metal clusters and organic ligands to form organic-inorganic hybrid materials with porous structure. Due to their adjustable frame structure, high porosity, good chemical stability, reproducibility, and simple synthesis process, they are widely used in active peptides enrichment, gas adsorption and separation, the areas of sensors, drug delivery and catalytic reactions. In this paper, the research progress of MOF materials as active peptide enrichment materials such as phosphopeptides, glycopeptides and endogenous peptides in recent years is reviewed, and the shortcomings and outlook of MOFs materials in this area are pointed out.

Contents

1 Introduction

2 MOFs for endogenous peptide enrichment

3 MOFs for glycopeptide enrichment

4 MOFs for phosphopeptide enrichment

5 Conclusion and outlook

Key words: metal-organic frameworks(MOFs), bioactive peptides, protein, enrichment
Table 1 Comparison of MOFs for endogenous peptide enrichment in recent years
sequence MOF LOD Real Sample Ref
1 MIL-53(Al) 2.0 pmol Human plasma and urine 26
2 Fe3O4-COOH@MIL-101(Cr) 0.25 pmol E. coli lysates 27
3 Fe3O4@MIL-100(Fe) 0.88 pmol Human serum 28
4 Fe3O4@[Cu3(btc)2] 2.0 fmol Human urine 29
5 Fe3O4/C@MIL-100(Fe) 2.5 fmol Human serum 30
6 Fe3O4@PDA@ZIF-8 15 fmol HSA tryptic digest 31
7 MGMOFs 1.0 pmol Human urine 32
8 CZIF 0.2 fmol Human serum 33
Fig. 1 The synthesis route of Fe3O4-COOH@MIL-101 composites and the flowchart of fast and convenient enrichment of biomarkers from cell lysates using Fe3O4-COOH@MIL-101 composites[27]
Table 2 Comparison of MOFs for glycopeptide enrichment in recent years
sequence MOF LOD Real Sample ref
1 Fe3O4@Mg-MOF-74 0.5 fmol Human serum 38
2 LCD-MOFs 3.3 fmol Mouse liver 39
3 MIL-101(Cr)-NH2 20 fmol Human serum 40
4 MIL-101(Cr)-maltose 1.0 fmol Human serum 41
5 MIL-101(NH2)@Au-Cys 1.0 pmol HeLa cell lysate 42
6 MIL-101(Cr)-NH2@PAMAM 1.0 fmol Human serum 43
7 UiO-66-COOH 0.5 fmol Human serum 44
8 Fe3O4@PDA@Zr-SO3H 0.1 fmol Human serum 45
9 MG@Zn-MOFs 0.8 fmol Human serum 46
10 Fe3O4@PDA@UiO-66-NH2 0.02 fmol Human serum 47
11 DZMOF-FDPn 0.1 fmol Human plasma 48
12 Fe3O4@mSiO2-IDA 1.0 fmol Human serum 49
Fig. 2 Synthesis route of MIL-101(NH2)@Au-Cys (a) and the enrichment procedure of glycopeptides (b)[42]
Fig. 3 Synthesis of MG@Zn-MOFs biocomposites and method for selective enrichment of glycopeptides by MG@Zn-MOFs[46]
Table 3 Comparison of MOFs for phosphopeptide enrichment in recent years
sequence MOF LOD Real Sample Ref
1 UiO-66 and UiO-67 15 fmol Human serum 15
2 Fe3O4@PDA@UiO-66-NH2 0.02 fmol Human serum 47
3 MIL-101(Cr)-UR2 20 fmol Non-fat milk 54
4 DZMOF 10 fmol Human saliva 55
5 Fe3O4@MIL-100(Fe) 0.5 fmol Human serum 56
6 Fe3O4@PDA@Zr-MOF 1.0 fmol Human serum 57
7 Fe3O4@PDA@Er(btc) 20 amol Human serum 58
8 Fe3O4/MIL-101(Fe) 8.0 fmol Tilapia eggs 59
9 magG@PDA@Zr-MOFs 100 fmol Human serum 60
10 HPT derived from MIL-125(Ti) 8.0 fmol Non-fat milk 61
11 SPIOs@PVP-PEI@MOF@Arg 10 pmol Non-fat milk 53
12 mMIL-125@Au@L-Cys 0.1 fmol Human crystalline lens 62
13 Fe3O4@PDA@Zr-Ti-MOF 1.0 nmol Human saliva. 63
14 UiO-66 incorporated poly(-MAA-co-PEGDA) - Nonfat milk 64
15 Fe3O4@MIL(Fe/Ti) 3 fmol Human serum 65
Fig. 4 Schematic representation of the synthesis and phosphopeptide enrichment of the SPMA nanospheres[53]
Fig. 5 Synthesis of Fe3O4@PDA@Zr-Ti-MOF and workflow for enrichment of phosphopeptides from biological samples[63]
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