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Progress in Chemistry 2019, Vol. 31 Issue (11): 1576-1590 DOI: 10.7536/PC190432 Previous Articles   Next Articles

Biomaterials for Regulating Cell Migration and Tissue Regeneration

Xingang Zuo, Haolan Zhang, Tong Zhou, Changyou Gao**()   

  1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received: Online: Published:
  • Contact: Changyou Gao
  • About author:
    ** E-mail:
  • Supported by:
    National Natural Science Foundation of China(51873188); National Natural Science Foundation of China(21434006)
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Regenerative biomaterials provide the necessary substances to support the growth of cells and tissues, maintain the shape and mechanical properties of regenerated tissues, and promote the integration with surrounding tissues. The surfaces and interfaces of biomaterials interact directly with cells and tissues, and thus significantly influencing on many cellular behaviors such as adhesion, spreading, proliferation, migration and differentiation as well as the outcomes of tissue repair and regeneration. Moreover, most tissues and organs possess a 3 dimensional shape with specific microstructures. Therefore, the construction of regenerative biomaterials with a 3 D shape and control over their microstructures are key issues as well. In this review, the recent works on the factors affecting cellular uptake of colloidal particles and cell adhesion are introduced. The adhesion and directional migration of cells mediated by gradient biomaterials are summarized. The latest works on migration of cells into 3 D hydrogels are reviewed. The implantable biomaterials with 3D microstructures for skin and cartilage repair and regeneration are also introduced. Finally, the application and perspectives of biomaterials in tissue regenerative are discussed.

Key words: biomaterials, surface and interface, cell migration, hydrogels, tissue engineering
Fig. 1 (a) Schematic illustration of PAH-Py microcapsule fabrication and 1D-NT protrusion, and(b) Chemical structures of PAH, Py-CHO, and PAH-Py [39]
Fig. 2 Schematic illustrations of(a) preparation of porphyrin micro-nano particles(MP-NPs) with nano-protrudent surface and the counterpart micro-particles(MPs), and(b) chemical reaction mechanism of formation and decomposition of PAH-g-Por.(c~h) Representative SEM images show the process of nanoparticles protruding on the surface of PAH-g-Por microparticles and the gradual turning into nano-spikes after being incubated in pH 1 HCl for 0 min(c), 10 min(d), 30 min(e), 1 h(f), 3 h(g), and 6 h(h), respectively. Scale bar in(c~h) is 1 μm[38]
Fig. 3 Stepwise seeding of fibroblasts and endothelial cells to obtain the anisotropic cell microspheres[44]
Fig. 4 Fabrication process of a CQAASIKVAV peptide-modified P(LLA-MTMC) film with stripe micropatterns, which promote the alignment and directional migration of Schwann cells as well as the neurite outgrowth of PC12 cells[18]
Fig. 5 Titanium nanotubes modified with thermal responsive polymers for stimuli-triggering release of loaded S1P[58]
Fig. 6 (a) A density gradient of VAPG peptides generated on the uniform PEG layer.(b) Influence of the VAPG density gradient on selective adhesion and migration of SMCs over FIBs [19]
Fig. 7 Formation of PHEMA/YIGSR complementary gradient and induced migration of endothelial cells[71]
Fig. 8 (a) Formation of PDMAPS/KHIFSDDSSEK complementary gradient and its induced migration to Schwann cells(SCs) over fibroblasts(FIBs),(b) Schematic illustration to show the fabrication of the complementary density gradient of KHI peptides and PDMAPS, whose densities are controlled by the precursory immobilized -N3 and -C(CH3)2Br derived from BCS and BES, respectively[72]
Fig. 9 (a) Schematic illustration to show the model of 3D cell migration.(b)(left) the Transwell mold, and(right) the Transwell mold loaded with an actual collagen-chitosan scaffold[75]
Fig. 10 Schematic illustrations of synthesis of MMP SP-crosslinked and cell-responsive MA-HA hydrogel, into which the migration behavior of SMCs is mediated by the cocultured U937 cells on the bottom well[76]
Fig. 11 Schematic illustrations of angiogenic sprouting from 3D-printed microchannels and directed migration behaviors of endothelial cells in hydrogels[77]
Fig. 12 Schematic illustration to show the preparation of(a,b,c) poly(lactide-co-glycolide) scaffold(O-PLGA) with radially oriented pores through unidirectional cooling.(d) O-PLGA scaffold used for regeneration of an osteochondral defect in a rabbit model[95]
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