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Progress in Chemistry 2019, Vol. 31 Issue (8): 1067-1074 DOI: 10.7536/PC190138 Previous Articles   Next Articles

Cell Membranes Functionalization Based on DNA

Jiangbo Liu1,2, Lihua Wang1, Xiaolei Zuo3,**()   

  1. 1. Division of Physical Biology & Bioimaging Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
    3. Institute of Molecular Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  • Received: Online: Published:
  • Contact: Xiaolei Zuo
  • About author:
    ** E-mail:
  • Supported by:
    “Shuguang Program” supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission, China(18SG16)
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Cell membranes play an important role in the process of material transportation, energy conversion and signal transduction between the cell and the external environment. Researching and controlling the interaction of molecules on the cell membranes is important to understand and manipulate the physiological functions of cells. Deoxyribonucleic acid(DNA) molecules have precise self-assembly and programmable properties and are a new tool for researching molecular interactions in bio-membranes. In this review, the method of modifying cell membranes with DNA molecules are outlined, followed by the work of monitoring and controlling the interaction of cell membranes molecules and the research of cell junction based on DNA. Simultaneously, the limitations of these research are analyzed. Finally, we summarize and prospect the research on DNA-based cell membranes functionalization. We hope that in-depth research in this field can promote new understanding of cell membranes function and obtain new methods for controlling cell function.

Key words: DNA, modification, cell membranes, functionalization
Fig. 1 Main methods of DNA modification on cell membranes[27]. Reproduced with permission from copyright(2012) American Chemical Society
Fig. 2 The visualization of glycosylation states of proteins with DNA[46]. Reproduced with permission from copyright(2018) American Chemical Society
Fig. 3 DNA-mediated chemically induced receptor tyrosine kinases dimerization[47]. (a) ATP-responsive D-CID. (b) Confocal fluorescence microscopy images for the study of ATP-responsible D-CID on a cell surface. (c) ATP induced fluorescence decay monitored by flow cytometry. (d) ATP-triggered c-Met phosphorylation determined by western blotting. Reproduced with permission from copyright(2018) Wiley
Fig. 4 DPAC reconstitutes the multicellular organization of organoid-like tissues[55].(a) Scheme showing the DPAC,(b) Incubation of cells with lipid modified oligonucleotides results in chemical remodeling of cell surfaces,(c) Procedure of DPAC,(d) Cell image during DPAC, scale bars, 100 μm. Reproduced with permission from copyright(2015) Nature Publishing Group
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