中文
Earlier issues
Announcement
More
Progress in Chemistry 2019, Vol. 31 Issue (2/3): 368-380 DOI: 10.7536/PC180630 Previous Articles   Next Articles

Carriers of Docetaxel: An Anticancer Drug

Sheng Feng, Fang Yang**(), Mengyao Liu, Hongxian Fan, Nian Xu   

  1. 1. Applied Chemistry, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, China
  • Received: Online: Published:
  • Contact: Fang Yang
  • About author:
    ** E-mail:
  • Supported by:
    Tianjin Municipal Natural Science Foundation for Youth(13JCQNJC05000); Hebei Province Natural Science Foundation for Youth(B2015202306)
Richhtml ( 2 ) PDF ( 716 ) Cited
Export

EndNote

Ris

BibTeX

Docetaxel is an effective anticancer drug. Due to its low water solubility and serious side effects brought about by solvent used, clinical application of docetaxel is restricted. Based on this problem, Establishing the carriers of docetaxel, an anticancer drug, by means of chemical synthesis has been attracting the attention of scientists. This article reviews the research progress of carriers of docetaxel in the past decade and discusses some problems in the current study, providing reference for the development and utilization of carriers of docetaxel.

Key words: docetaxel, polymer carrier, inorganic material, liposome, low molecular surfactant
Fig. 1 Preparation of CMCS-DTX[8]
Fig. 2 Schematic representation of the structures of the star polymer conjugates[10]
Fig. 3 Schematic representation of the structure of CD-PLLD[14]
Fig. 4 Two block-polymer micelle package DTX[19]
Fig. 5 Three block polymer micelle PEG-PLL-PLLeu[21]
Fig. 6 Cross linked star micelle with tripodal cyclotriphosphazene amphiphile[24]
Fig. 7 Two block polymeric micelles of oligopeptide and MPEG[24]
Fig. 8 VE-PEG-PLG graft copolymer micelles[27]
Fig. 9 Schematic diagram of HPMAmLac2-MPEG micelle[30]
Fig. 10 Shell-cross-linked PEG-PLys-PPhe three block copolymer micelle[32]
Fig. 11 HA-PLGA/DTX nanoparticles[34]
Fig. 12 Ionicallycross-linked docetaxel loaded chitosan nanoparticles[35]
Fig. 13 H40-PLA-TPGS dendritic polymer nanoparticles[38]
Fig. 14 Model of super paramagnetic iron oxide(SPIO) nanocrystals for delivery DTX[43]
Fig. 15 Carbon nanotube loaded DTX[45]
Fig. 16 C60 fullerene as DTX carrier[47]
Fig. 17 Calcium phosphate nanoparticles loaded with DTX[51]
Fig. 18 Normal liposome model of load DTX
Fig. 19 Thermal sensitive liposomes loaded with DTX[59]
Fig. 20 long circulating liposomes loaded siRNA and DTX[60]
Fig. 21 Long-circulating liposomes loaded GEM and DTX[61]
Fig. 22 Liposome of DTX modified by double peptide[62]
[1]
Clarke S J, Rivory L P . Clin. Pharmacokinet., 1999,36(2):99. https://www.ncbi.nlm.nih.gov/pubmed/10092957

doi: 10.2165/00003088-199936020-00002 pmid: 10092957
[2]
Lee J M, Park H, Oh K T, Lee E S . Int. J. Pharm., 2018,547:377. https://www.ncbi.nlm.nih.gov/pubmed/29902507

doi: 10.1016/j.ijpharm.2018.06.028 pmid: 29902507
[3]
Shaikh M, Choudhury N R, Knott R, Garg S . Mol. Pharmaceutics, 2015,12(7):2305. https://www.ncbi.nlm.nih.gov/pubmed/25936529

doi: 10.1021/mp500851u pmid: 25936529
[4]
Yang C, Han L N, Ma F, Zhou L, Zhou J H, Wei S H, Huang G Q, Shen J, Li F Y . Int. J. Appl. Ceram. Technol., 2015,12(2):300.
[5]
Duncan R, Izzo L . Adv. Drug Delivery Rev., 2005,57:2215. https://www.ncbi.nlm.nih.gov/pubmed/16297497

doi: 10.1016/j.addr.2005.09.019 pmid: 16297497
[6]
Generalova A N, Zubov V P . Colloids Surf. B: Biointerfaces, 2018,166:303. https://www.ncbi.nlm.nih.gov/pubmed/29604573

doi: 10.1016/j.colsurfb.2018.03.036 pmid: 29604573
[7]
Wolinsky J B, Grinstaff M W . Adv. Drug Delivery Rev., 2008,60:1037. https://www.ncbi.nlm.nih.gov/pubmed/18448187

doi: 10.1016/j.addr.2008.02.012 pmid: 18448187
[8]
Liu F X, Feng L X, Zhang L, Zhang X, Zhang N . Int. J. Pharm., 2013,451:41. https://www.ncbi.nlm.nih.gov/pubmed/23608199

doi: 10.1016/j.ijpharm.2013.04.020 pmid: 23608199
[9]
Ernsting M J, Tang W L, Maccallum N W, Li S D . Biomaterials 2012,33:1445. https://www.ncbi.nlm.nih.gov/pubmed/22079003

doi: 10.1016/j.biomaterials.2011.10.061 pmid: 22079003
[10]
Etrych T, Strohalm J, Šírová M, Tomalová B, Rossmann P, $breve{R}$íhová B, Ulbricha K, Ková$breve{r}$ M . Polym. Chem., 2015,6:160.
[11]
Fang J, Nakamura H, Maeda H . Adv. Drug. Deliv. Rev., 2011,63:136. https://www.ncbi.nlm.nih.gov/pubmed/20441782

doi: 10.1016/j.addr.2010.04.009 pmid: 20441782
[12]
Wu M X, Yang Y W . Chin. Chem. Lett., 2017,28:1135.
[13]
Danhier F, Feron O, Preat V . J. Control Release, 2010,148:135. https://www.ncbi.nlm.nih.gov/pubmed/20797419

doi: 10.1016/j.jconrel.2010.08.027 pmid: 20797419
[14]
Liu T, Xue W, Ke B, Xie M Q, Ma D . Biomaterials. 2014,(35):3865. https://www.ncbi.nlm.nih.gov/pubmed/24486215

doi: 10.1016/j.biomaterials.2014.01.040 pmid: 24486215
[15]
Cheng H X, Liu H, Chen W, Zhou G L . China Journal of Hosital Pharmacy, 2010,30(8):1541.
[16]
Lipinski C A . J. Pharmacol. Toxicol. Methods, 2000,44:235. https://www.ncbi.nlm.nih.gov/pubmed/11274893

doi: 10.1016/s1056-8719(00)00107-6 pmid: 11274893
[17]
Vassilomanolakis M, Koumakis G, Barbounis V, Demiri M, Panopoulos C, Chrissohoou M . Breast, 2005,14:136. https://www.ncbi.nlm.nih.gov/pubmed/15767183

doi: 10.1016/j.breast.2004.08.017 pmid: 15767183
[18]
Rowinsky E K, Donehower R C . Pharmacol T., 1991,52:35.
[19]
Wang Y J, Chen L J, Tan L W, Zhao Q, Luo F, Wei Y Q, Qian Z Y . Biomaterials, 2014,35:6972. https://www.ncbi.nlm.nih.gov/pubmed/24836952

doi: 10.1016/j.biomaterials.2014.04.099 pmid: 24836952
[20]
Cheng D, Gao N, Chen J, Yu X, Shuai X . Biomaterials, 2012,33:1170. https://www.ncbi.nlm.nih.gov/pubmed/22061491

doi: 10.1016/j.biomaterials.2011.10.057 pmid: 22061491
[21]
Zheng C F, Zheng M B, Gong P, Deng J Z, Yi H Q, Zhang P F, Zhang Y J, Liu P, Ma Y F, Cai L T . Biomaterials, 2013,34:3431. https://www.ncbi.nlm.nih.gov/pubmed/23375952

doi: 10.1016/j.biomaterials.2013.01.053 pmid: 23375952
[22]
Gaucher G, Marchessault R H, Leroux J C . J. Control Release, 2010,143:2. https://www.ncbi.nlm.nih.gov/pubmed/19925835

doi: 10.1016/j.jconrel.2009.11.012 pmid: 19925835
[23]
Pan D . Master Dissertation of Tianjin University, 2012.
[24]
Jun Y J, Jadhav V B, Min J H, Cui J X, Chae S W, Choi J M, Kim I S, Choi S J, Lee H J, Sohn Y S . Int. J. Pharm., 2012,422:374. https://www.ncbi.nlm.nih.gov/pubmed/22079718

doi: 10.1016/j.ijpharm.2011.10.052 pmid: 22079718
[25]
Pan D, Zhao Y J, Wang Z . J. Int. Pharm. Res., 2012,4:294.
[26]
Cabral H, Nishiyama N, Kataoka K . Acc Chem. Res., 2011,44:999. https://www.ncbi.nlm.nih.gov/pubmed/21755933

doi: 10.1021/ar200094a pmid: 21755933
[27]
Song W T, Tang Z H, Zhang D W, Zhang Y, Yu H Y, Li M Q, Lv S X, Sun H, Deng M X, Chen X S . Biomaterials, 2014,35:3005. https://www.ncbi.nlm.nih.gov/pubmed/24388813

doi: 10.1016/j.biomaterials.2013.12.018 pmid: 24388813
[28]
Zhong H L . Master Dissertation of Zhejiang University. 2006.
[29]
Jain R K, Stylianopoulos T . Nat. Rev. Clin. Oncol., 2010,7:653. https://www.ncbi.nlm.nih.gov/pubmed/20838415

doi: 10.1038/nrclinonc.2010.139 pmid: 20838415
[30]
Hu Q Z, Rijcken C J, Bansal R, Hennink W E, Storm G, Prakash J . Biomaterials, 2015,53:370. https://www.ncbi.nlm.nih.gov/pubmed/25890735

doi: 10.1016/j.biomaterials.2015.02.085 pmid: 25890735
[31]
Yu J M, WU J Z, Wang X S, Jin Y . Acta Pharmaceutica Sinica, 2014,49(2):183. https://www.ncbi.nlm.nih.gov/pubmed/24761607

pmid: 24761607
[32]
Koo A N, Min K H, Lee H J, Lee S U, Kim K, Kwon I C, Cho S H, Jeong S Y, Lee S C . Biomaterials. 2012,33:1489. https://www.ncbi.nlm.nih.gov/pubmed/22130564

doi: 10.1016/j.biomaterials.2011.11.013 pmid: 22130564
[33]
Cho H, Lai T C, Kwon G S . J. Controlled Release, 2013,166(1):1.
[34]
Pradhana R, Ramasamya T, Choia J Y, Kima J H, Poudela, B K Taka J W, Nukolovab N, Choic H G, Chul S, Yonga J O K . Carbohydr. Polym., 2015,123:313. https://www.ncbi.nlm.nih.gov/pubmed/25843864

doi: 10.1016/j.carbpol.2015.01.064 pmid: 25843864
[35]
Jain At, Thakur K, Sharma G, Kusha P, Jain U K . Carbohydr. Polym., 2016,137:65. https://www.ncbi.nlm.nih.gov/pubmed/26686106

doi: 10.1016/j.carbpol.2015.10.012 pmid: 26686106
[36]
Wang A, Sun Y, Gao L, Li H . Carbohydr. Polym., 2009,75(4):566.
[37]
Cha L S, Gao H F, Yang W L, Jiang X G, Fu S K . Chin. Polym. Bull., 2002,(3):24.
[38]
Zeng X W, Tao W, Wang Z Y, Zhang X D, Zhu H J, Wu Y P, Gao Y F, Liu K W, Jiang Y Y, Huang L Q, Mei L, Feng S S . Part. Part. Syst. Charact., 2015,(32):112.
[39]
Li L, Tan Y B . Colloid Interface Sci., 2008, 317,(1):326. https://www.ncbi.nlm.nih.gov/pubmed/17927997

doi: 10.1016/j.jcis.2007.09.053 pmid: 17927997
[40]
Wu W T, Shi W J, Wu Q Z, Zhou J P . Prog. Pharm. Sci., 2013,37(5):222
[41]
Brindle K . Nat. Rev. Cancer, 2008,8:94. https://www.ncbi.nlm.nih.gov/pubmed/18202697

doi: 10.1038/nrc2289 pmid: 18202697
[42]
Gu H . Master Dissertation of Yangzhou University. 2014
[43]
Ling Y, Wei K, Luo Y, Gao X, Zhong S Z . Biomaterials, 2011,32:7139. https://www.ncbi.nlm.nih.gov/pubmed/21726899

doi: 10.1016/j.biomaterials.2011.05.089 pmid: 21726899
[44]
Piskorz J, Skupin P, Lijewski S, Korpusinski M, Sciepura M, Konopka K, Sobiak S, Goslinski T, Mielcarek J . J. Fluor. Chem., 2012,135:265.
[45]
Wang L, Zhang M Y, Zhang N, Shi J J, Zhang H L, Min Li, Lu C, Zhang Z Z . Int. J. Nanomedicine, 2011,6:2641. https://www.ncbi.nlm.nih.gov/pubmed/22114495

doi: 10.2147/IJN.S24167 pmid: 22114495
[46]
Aoshima H, Saitoh Y, Ito S, Yamana S, Miwa N J . Toxicol. Sci., 2009,34:555. https://www.ncbi.nlm.nih.gov/pubmed/19797864

doi: 10.2131/jts.34.555 pmid: 19797864
[47]
Raza K, Thotakura N, Kumar P, Joshi M, Bhushan S, Bhatia A, Kumar V, Malik R, Sharma G, Guru S K, Katare O P . Int. J. Pharm., 2015,495:551. https://linkinghub.elsevier.com/retrieve/pii/S0378517315302143

doi: 10.1016/j.ijpharm.2015.09.016
[48]
Zhou Y X, Quan G L, Wu Q L, Zhang X X, Niu B Y, Wu B Y, Huang Y, Pan X, Wu C B . Acta Pharmaceutica Sinica B, 2018,8(2):165. https://www.ncbi.nlm.nih.gov/pubmed/29719777

doi: 10.1016/j.apsb.2018.01.007 pmid: 29719777
[49]
Li L L, Tang F Q, Liu H Y, Liu T L, Hao N J, Chen D, Teng X, He J Q . ACS Nano, 2010,4(11):6874. https://www.ncbi.nlm.nih.gov/pubmed/20973487

doi: 10.1021/nn100918a pmid: 20973487
[50]
Jinturkar K A, Anish C, Kumar M K, Bagchi T, Panda A K, Misra A R . Biomaterials, 2012,33(8):2492. https://www.ncbi.nlm.nih.gov/pubmed/22200537

doi: 10.1016/j.biomaterials.2011.11.067 pmid: 22200537
[51]
Yang C, Han L N, Zhou L, Zhou J H, Wei S H, Shen J . Int. J. Appl. Ceram. Technol., 2015,12(2):300.
[52]
Dou Y, Hynynen K, Allen C . J. Control Release, 2017,249:63. https://www.ncbi.nlm.nih.gov/pubmed/28122204

doi: 10.1016/j.jconrel.2017.01.025 pmid: 28122204
[53]
Immordino M L, Brusa P, Arpicco S, Stella B, Dosio F, Cattel L . J. Controlled Release, 2003,91(3):417. https://www.ncbi.nlm.nih.gov/pubmed/12932719

doi: 10.1016/s0168-3659(03)00271-2 pmid: 12932719
[54]
Zhang H, Gong W, Wang Z Y, Yuan Sh J, Xie X Y, Yang Y F, Yang Y, Wang S S, Yang D X, Xuan Z X, Mei X G . J. Pharm. Sci., 2014,103(7):2177. https://www.ncbi.nlm.nih.gov/pubmed/24846075

doi: 10.1002/jps.24019 pmid: 24846075
[55]
Zhang C X, Wang D K, Zhang W T, Ling L F . Chinese Journal of New Drugs, 2007,16(10):782. https://www.ncbi.nlm.nih.gov/pubmed/30322612

doi: 10.1016/S1875-5364(18)30118-3 pmid: 30322612
[56]
Wang D K, Zhang C X, Zhang W T, Zhao C H, Guan S X . J. Drug Del. Sci. Tech., 2008,18(4):253.
[57]
Bucke W E, Leitzke S, Diederichs J E . J. Drug Target, 1998,5:99. https://www.ncbi.nlm.nih.gov/pubmed/9588866

doi: 10.3109/10611869808995863 pmid: 9588866
[58]
Centelles M N, Wright M, So P, Amrahli M, Xu X Y, Justin S, Miller A D, Gedroyc W, Thanou M . J. Control Release, 2018,280:87. https://www.ncbi.nlm.nih.gov/pubmed/29723616

doi: 10.1016/j.jconrel.2018.04.047 pmid: 29723616
[59]
Zhang H, Gong W, Wang Z Y . Pharmaceutical Nanotechnology, 2014,4:2177.
[60]
Qu M H, Zeng R F, Fang S, Dai Q S, Li H P, Long J T . Int. J. Pharm., 2014,474:112. https://www.ncbi.nlm.nih.gov/pubmed/25138252

doi: 10.1016/j.ijpharm.2014.08.019 pmid: 25138252
[61]
Sun L, Zhou D S, Zhang P, Li Q H, Liu P . Int. J. Pharm., 2015,478:308. https://www.ncbi.nlm.nih.gov/pubmed/25433201

doi: 10.1016/j.ijpharm.2014.11.052 pmid: 25433201
[62]
Yang Z Z, Li J Q, Wang Z Z, Dong D W, Qi X R . Biomaterials, 2014,35:5226. 5c2d4080-b623-409c-9b9e-4f26684b59a6http://dx.doi.org/10.1016/j.biomaterials.2014.03.017

doi: 10.1016/j.biomaterials.2014.03.017
[63]
Zhai G X, Wu J, Y B . J. Nanosci. Nanotechnol., 2010,10(8):5129. https://www.ncbi.nlm.nih.gov/pubmed/21125861

doi: 10.1166/jnn.2010.2393 pmid: 21125861
[64]
Guha I F, Varanasi K K . Curr. Opin. Colloid Interface Sci., 2018,36:110.
[65]
Balakrishnan P, Lee B J, Oh D H, Kim J O, Lee Y I, Kim D D, Jee J P, Lee Y B, Woo J S, Yong C S, Choi H G . Int. J. Pharm., 2009,374:66. https://www.ncbi.nlm.nih.gov/pubmed/19446761

doi: 10.1016/j.ijpharm.2009.03.008 pmid: 19446761
[66]
Wang L, Dong J, Chen J, Eastoe J, Li X . J. Colloid Interface Sci., 2009,330:443. https://linkinghub.elsevier.com/retrieve/pii/S0021979708014355

doi: 10.1016/j.jcis.2008.10.077
[67]
Seo Y G, Kim D H, Ramasamy T, Kim J H, Marasini N, Oh Y K, Kim D W, Kim J K, Yong C S, Kim J O, Choi H G . Int. J. Pharm., 2013,452:412. https://www.ncbi.nlm.nih.gov/pubmed/23707964

doi: 10.1016/j.ijpharm.2013.05.034 pmid: 23707964
[68]
Wang X L, Zhang X R, Gong T, Zhang Z R, Weber L, Wei X J . Tradit. Chin. Med. Sci., 2018,5:139.
[69]
Deng D M, Zhu H L, Zhao J . Chin. J. Hosp. Pharm., 2001,21(5):266.
[70]
Li L, Wang D K, Li L S, Jia J, Chang D, Ai L . Journal of Shenyang Pharmaceutical University, 2007,24(12):727.
[71]
Yao H J . Chinese Pharmaceutical Information, 2001,17(5):29.
[72]
Dumont C, Bourgeois S, Fessi H, Jannin V . Int. J. Pharm., 2018,514:117.
[73]
Patravale V B, Date A A, Kulkarni R M . Pharmacol J. Pharm., 2004,56(7):827. https://www.ncbi.nlm.nih.gov/pubmed/15233860

doi: 10.1211/0022357023691 pmid: 15233860
[74]
Wang L L, Liu Z H, Liu D H, Liu C X, Juan Z, Zhang N . Int. J. Pharm., 2011,413:194. https://www.ncbi.nlm.nih.gov/pubmed/21540085

doi: 10.1016/j.ijpharm.2011.04.023 pmid: 21540085
[75]
Wang L L, Li M, Zhang N . Int. J. Nanomedicine, 2012,7:3281. https://www.ncbi.nlm.nih.gov/pubmed/22802688

doi: 10.2147/IJN.S32520 pmid: 22802688
[76]
DeBoyace K, Wildfong P LD . J. Pharm. Sci., 2018,107(1):57. https://www.ncbi.nlm.nih.gov/pubmed/28389266

doi: 10.1016/j.xphs.2017.03.029 pmid: 28389266
[77]
Brouwers J., Brewster M E, Augustijns P, Pharm J . Sci., 2009,98:2549.
[78]
Moes J J, Koolen S L W, Huitema A D R., Schellens J H M, Beijnen J H, Nuijen B . Int. J. Pharm., 2011,420:244. https://www.ncbi.nlm.nih.gov/pubmed/21907780

doi: 10.1016/j.ijpharm.2011.08.041 pmid: 21907780
[79]
Nei B, Jin C F, Zhong W H, Ren Q Y, Zhang Y J, Zhang Q . Chin. Org. Chem., 2017,37:2818.
[80]
Zhu Q W, Yu X M, Shen Q Q, Zhang Q M, Su M B, Zhou Y B, Li J, Chen Y, Lu W . Bioorg. Med. Chem. 2018,26:4706. https://www.ncbi.nlm.nih.gov/pubmed/30115492

doi: 10.1016/j.bmc.2018.08.008 pmid: 30115492
[81]
Tian R . Doctor Dissertation of Chongqing Medical University. 2012.
[82]
Zhang B H, Zhang J X, Chen L F . CN 101209350. 2008.
[83]
Du W T, Hong L, Yao T W, Yang X C, He Q J, Yang B, Hu Y Z . Bioorg. Med. Chem., 2007,15(18):6323. https://www.ncbi.nlm.nih.gov/pubmed/17624790

doi: 10.1016/j.bmc.2007.04.002 pmid: 17624790
[84]
Bally M, Ciufolini M, Cullis P, Jigaltsev I, Maurer N . EP 2282724A2, 2009.
[1] Tianxi He, Qionglin Liang, Jiu Wang, Guoan Luo. Microfluidic Fabrication of Liposomes as Drug Carriers [J]. Progress in Chemistry, 2018, 30(11): 1734-1748.
[2] Jie Tang, Renfa Liu, Zhifei Dai*. Multifunctional Liposomal Drug Delivery Technology [J]. Progress in Chemistry, 2018, 30(11): 1669-1680.
[3] Liu Baoquan, Liu Qiang, Zhang Ji, Fan Shengdi, Yu Xiaoqi. Transfection of Nucleic Acids Mediated by Macrocyclic Polyamine-Based Liposomes [J]. Progress in Chemistry, 2013, 25(08): 1237-1245.
[4] Liu Ruilai, Liu Haiqing, Liu Junshao, Jiang Huihua. Fabrication of Patterned Inorganic Nanofibers by Electrospinning [J]. Progress in Chemistry, 2012, 24(08): 1484-1496.
[5] Jing Jing, Li Yi, Liu Jian, Zhan Sihui. Liposome Formation with Electroformation Method [J]. Progress in Chemistry, 2011, 23(12): 2598-2606.
[6] . Inorganic Synthesis in Ionic Liquids [J]. Progress in Chemistry, 2009, 21(10): 2077-2083.
[7] He Junhui1**, Chen Hongmin1,2,Zhang Lin3. Inorganic Hollow Micro/Nanospheres [J]. Progress in Chemistry, 2007, 19(10): 1488-1494.
[8] Cao Jieming*,Fang Baoqing,Wang Jun,Zheng Mingbo,Deng Shaogao,Ma Xianjia. Ionic Liquids for the Convenient Synthesis of Functional Inorganic Nanomaterials [J]. Progress in Chemistry, 2005, 17(06): 1028-1033.
[9] Mao Chuanbin,Li Hengde,Cui Fuzhai,Feng Qingling,Wang Hao. Biomimetic Synthesis of Inorganic Materials [J]. Progress in Chemistry, 1998, 10(03): 246-.
Viewed
Full text


Abstract

Carriers of Docetaxel: An Anticancer Drug