中文
Earlier issues
Announcement
More
Progress in Chemistry 2018, Vol. 30 Issue (10): 1584-1591 DOI: 10.7536/PC180616 Previous Articles   Next Articles

• Review •

Inorganic Nanomaterials for Tumor Comprehensive Therapy

Jun Hu, Yuzhu Yao, Yanxiao Ao, Hai Yang, Xiangliang Yang*, Huibi Xu   

  1. School of Life Science and Technology, National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan 430074, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 81771978).
PDF ( 731 ) Cited
Export

EndNote

Ris

BibTeX

Inorganic nanomaterials are widely applied in the diagnosis and comprehensive therapy of multiple diseases, in particular tumors, because of their unique nano-characters. Superparamagnetic iron oxide nanoparticles, upconversion nanoparticles and noble metal nanoparticles are the representative ones, possessing excellent magnetic, optical and thermal properties respectively. In this review, we focus on the applications of the three kinds of inorganic nanomaterials in bio-detection in vitro, molecular imaging in vivo, targeting anti-tumor drug delivery and tumor therapy. The advantages as well as the limitations of them in tumor theranostics are discussed. By this way, some references and suggestions are provided to develop more biocompatible inorganic nanomaterials with better theranostic effects, which will promote their clinical transformation.
Contents
1 Introduction
2 Superparamagnetic iron oxide nanoparticles
2.1 Separation and detection in vitro
2.2 Magnetic resonance imaging
2.3 Magnetic hyperthermia therapy
3 Upconversion nanoparticles
3.1 Multimodality imaging
3.2 Comprehensive therapy of tumor
4 Noble metal (Au、Pt) nanoparticles
5 Conclusion and outlook
Key words: inorganic nanomaterials, tumor, diagnosis, comprehensive therapy

CLC Number: 

[1] Hu X X, Wang Y Q, Liu H Y, Wang J, Tan Y N, Wang F B, Yuan Q, Tan W H. Chem. Sci., 2017, 8:466.
[2] Liu W, Nie L, Li F, Aguilar Z P, Xu H, Xiong Y, Fu F, Xu H. Biomater. Sci., 2016, 4:159.
[3] Fang S, Wang C, Xiang J, Cheng L, Song X, Xu L, Peng R, Liu Z. Nano Res., 2014, 7:1327.
[4] Song E Q, Hu J, Wen C Y, Tian Z Q, Yu X, Zhang Z L, Shi Y B, Pang D W. ACS Nano, 2011, 5:761.
[5] Guo P L, Tang M, Hong S L, Yu X, Pang D W, Zhang Z L. Biosens. Bioelectron., 2015, 74:628.
[6] Kim Y T, Kim K H, Kang E S, Jo G, Ahn S Y, Park S H, Kim S I, Mun S, Baek K, Kim B, Lee K, Yun W S, Kim Y H. Bioconjugate Chem., 2016, 27:59.
[7] Wen C Y, Hu J, Zhang Z L, Tian Z Q, Ou G P, Liao Y L, Li Y, Xie M, Sun Z Y, Pang D W. Anal. Chem., 2013, 85:1223.
[8] Wu Z, Zhou C H, Chen J J, Xiong C, Chen Z, Pang D W, Zhang Z L. Biosens. Bioelectron., 2015, 68:586.
[9] Ali Z, Wang J, Tang Y, Liu B, He N, Li Z. Biomater. Sci., 2017, 5:57.
[10] Li C C, Zhang Y, Tang B, Zhang C Y. Chem. Commun., 2018, 54:5839.
[11] Xu D D, Deng Y L, Li C Y, Lin Y, Tang H W. Biosens. Bioelectron., 2017, 87:881.
[12] Yue S, Zhao T, Bi S, Zhang Z. Biosens. Bioelectron., 2017, 98:234.
[13] Liu Z, Zhang L, Yang H, Zhu Y, Jin W, Song Q, Yang X. Anal. Biochem., 2010, 404:127.
[14] Yu Q, Yang H, Feng Y, Yang X, Zhu Y. Acta Trop., 2012, 124:199.
[15] Yu Q, Yang H, Feng Y, Zhu Y, Yang X. Am. J. Trop. Med. Hyg., 2012, 87:689.
[16] Yu Q, Yang H, Guan F, Feng Y, Yang X, Zhu Y. Trans. Roy. Soc. Trop. Med. Hyg., 2014, 108:37.
[17] 胡军(Hu J). 武汉大学博士论文(Doctoral Dissertation of Wuhan University), 2011.
[18] Hu J, Xie M, Wen C Y, Zhang Z L, Xie H Y, Liu A A, Chen Y Y, Zhou S M, Pang D W. Biomaterials, 2011, 32:1177.
[19] Hu J, Wen C Y, Zhang Z L, Xie M, Xie H Y, Pang D W. Biophys. J., 2014, 107:165.
[20] Xie M, Hu J, Wen C Y, Zhang Z L, Xie H Y, Pang D W. Nanotechnology, 2012, 23:035602.
[21] Hu J, Wen C Y, Zhang Z L, Xie M, Hu J, Wu M, Pang D W. Anal. Chem., 2013, 85:11929.
[22] Xie H, Zhu Y, Jiang W, Zhou Q, Yang H, Gu N, Zhang Y, Xu H, Xu H, Yang X. Biomaterials, 2011, 32:495.
[23] Jiang L, Zhou Q, Mu K, Xie H, Zhu Y, Zhu W, Zhao Y, Xu H, Yang X. Biomaterials, 2013, 34:7418.
[24] Qi H, Li Z, Du K, Mu K, Zhou Q, Liang S, Zhu W, Yang X, Zhu Y. Nanoscale Res. Lett., 2014, 9:595.
[25] Liang S, Zhou Q, Wang M, Zhu Y, Wu Q, Yang X. Int. J. Nanomed., 2015, 10:2325.
[26] Zhou Q, Mu K, Jiang L, Xie H, Liu W, Li Z, Qi H, Liang S, Xu H, Zhu Y, Zhu W, Yang X. Int. J. Nanomed., 2015, 10:1805.
[27] Chen Y, Zhou Q, Li X, Wang F, Heist K, Kuick R, Owens S R, Wang T D. Bioconjugate Chem., 2017, 28:2794.
[28] Jiao M, Jing L, Wei X, Liu C, Luo X, Gao M. Nanoscale, 2017, 9:18609.
[29] Shen Z, Chen T, Ma X, Ren W, Zhou Z, Zhu G, Zhang A, Liu Y, Song J, Li Z, Ruan H, Fan W, Lin L, Munasinghe J, Chen X, Wu A. ACS Nano, 2017, 11:10992.
[30] Yang G, Zhang R, Liang C, Zhao H, Yi X, Shen S, Yang K, Cheng L, Liu Z. Small, 2018, 14:1702664.
[31] Kim B H, Lee N, Kim H, An K, Park Y I, Choi Y, Shin K, Lee Y, Kwon S G, Na H B, Park J G, Ahn T Y, Kim Y W, Moon W K, Choi S H, Hyeon T. J. Am. Chem. Soc., 2011, 133:12624.
[32] Bao Y, Sherwood J A, Sun Z. J. Mater. Chem. C, 2018, 6:1280.
[33] Ghosh R, Pradhan L, Devi Y P, Meena S S, Tewari R, Kumar A, Sharma S, Gajbhiye N S, Vatsa R K, Pandey B N, Ningthoujam R S. J. Mater. Chem., 2011, 21:13388.
[34] Kumar C S S R, Mohammad F. Adv. Drug Deliv. Rev., 2011, 63:789.
[35] Gilchrist R K, Medal R, Shorey W D, Hanselman R C, Parrott J C, Taylor C B. Ann. Surg., 1957, 146:596.
[36] Ding Q, Liu D F, Guo D W, Yang F, Pang X Y, Che B R E, Zhou N Z, Xie J, Sun J F, Huang Z H, Gu N. Biomaterials, 2017, 124:35.
[37] Nemati Z, Alonso J, Martinez L M, Khurshid H, Garaio E, Garcia J A, Phan M H, Srikanth H. J. Phys. Chem. C, 2016, 120:8370.
[38] Coral D F, Mendoza Zelis P, Marciello M, del Puerto Morales M, Craievich A, Sanchez F H, Fernandez van Raap M B. Langmuir, 2016, 32:1201.
[39] Niculaes D, Lak A, Anyfantis G C, Marras S, Laslett O, Avugadda S K, Cassani M, Serantes D, Hovorka O, Chantrell R, Pellegrino T. ACS Nano, 2017, 11:12121.
[40] Filippousi M, Angelakeris M, Katsikini M, Paloura E, Efthimiopoulos I, Wang Y, Zambouis D, Van Tendeloo G. J. Phys. Chem. C, 2014, 118:16209.
[41] Jadhav S V, Lee S H, Nikam D S, Bohara R A, Pawar S H, Yu Y S. New J. Chem., 2017, 41:1598.
[42] Das R, Alonso J, Porshokouh Z N, Kalappattil V, Torres D, Phan M H, Garaio E, Garcia J A, Llamazares J L S, Srikanth H. J. Phys. Chem. C, 2016, 120:10086.
[43] Yan H, Shang W T, Sun X D, Zhao L Y, Wang J Y, Xiong Z Y, Yuan J, Zhang R R, Huang Q L, Wang K, Li B H, Tian J, Kang F Y, Feng S S. Adv. Funct. Mater., 2018, 28:1705710.
[44] Tay Z W, Chandrasekharan P, Chiu Lam A, Hensley D W, Dhavalikar R, Zhou X Y, Yu E Y, Goodwill P W, Zheng B, Rinaldi C, Conolly S M. ACS Nano, 2018, 12:3699.
[45] Monzel C, Vicario C, Piehler J, Coppey M, Dahan M. Chem. Sci., 2017, 8:7330.
[46] Chiang C S, Tseng Y H, Liao B J, Chen S Y. Adv. Healthc. Mater., 2015, 4:1066.
[47] Liu B, Li C, Ma P a, Chen Y, Zhang Y, Hou Z, Huang S, Lin J. Nanoscale, 2015, 7:1839.
[48] Yu J, Yin W, Zheng X, Tian G, Zhang X, Bao T, Dong X, Wang Z, Gu Z, Ma X, Zhao Y. Theranostics, 2015, 5:931.
[49] Bai J, Wang J T W, Rubio N, Protti A, Heidari H, Elgogary R, Southern P, Al Jamal W T, Sosabowski J, Shah A M, Bals S, Pankhurst Q A, Al Jamal K T. Theranostics, 2016, 6:342.
[50] Chen X Z, Hoop M, Shamsudhin N, Huang T, Ozkale B, Li Q, Siringil E, Mushtaq F, Di Tizio L, Nelson B J, Pane S. Adv. Mater., 2017, 29:1605458.
[51] Sun X, Dong B, Xu H, Xu S, Zhang X, Lin Y, Xu L, Bai X, Zhang S, Song H. ACS Appl. Mater. Interfaces, 2017, 9:11451.
[52] Wang F J, Yang Y, Ling Y, Liu J X, Cai X J, Zhou X H, Tang X Z, Liang B, Chen Y N, Chen H R, Chen D M, Li C H, Wang Z G, Hu B, Zheng Y Y. Biomaterials, 2017, 128:84.
[53] Kim H C, Kim E, Jeong S W, Ha T L, Park S I, Lee S G, Lee S J, Lee S W. Nanoscale, 2015, 7:16470.
[54] Kakwere H, Leal M P, Materia M E, Curcio A, Guardia P, Niculaes D, Marotta R, Falqui A, Pellegrino T. ACS Appl. Mater. Interfaces, 2015, 7:10132.
[55] Yin P T, Shah S, Pasquale N J, Garbuzenko O B, Minko T, Lee K B. Biomaterials, 2016, 81:46.
[56] Kim K S, Kim J, Lee J Y, Matsuda S, Hideshima S, Mori Y, Osaka T, Na K. Nanoscale, 2016, 8:11625.
[57] Gulzar A, Xu J T, Yang P P, He F, Xu L G. Nanoscale, 2017, 9:12248.
[58] Zhan Q Q, Qian J, Liang H J, Somesfalean G, Wang D, He S L, Zhang Z G, Andersson Engels S. ACS Nano, 2011, 5:3744.
[59] Kostiv U, Kotelnikov I, Proks V, Slouf M, Kucka J, Engstova H, Jezek P, Horak D. ACS Appl. Mater. Interfaces, 2016, 8:20422.
[60] Xue Z L, Yi Z G, Li X L, Li Y B, Jiang M Y, Liu H R, Zeng S J. Biomaterials, 2017, 115:90.
[61] Cheng L, Wang C, Ma X X, Wang Q L, Cheng Y, Wang H, Li Y G, Liu Z. Adv. Funct. Mater., 2013, 23:272.
[62] Gai S L, Li C X, Yang P P, Lin J. Chem. Rev., 2014, 114:2343.
[63] Zhang Y, Yu Z Z, Li J Q, Ao Y X, Xue J W, Zeng Z P, Yang X L, Tan T T Y. ACS Nano, 2017, 11:2846.
[64] Tian G, Yin W Y, Jin J J, Zhang X, Xing G M, Li S J, Gu Z J, Zhao Y L. J. Mater. Chem. B, 2014, 2:1379.
[65] Tian G, Gu Z, Zhou L, Yin W, Liu X, Yan L, Jin S, Ren W, Xing G, Li S, Zhao Y. Adv. Mater., 2012, 24:1226.
[66] Wang C, Cheng L, Liu Y M, Wang X J, Ma X X, Deng Z Y, Li Y G, Liu Z. Adv. Funct. Mater., 2013, 23:3077.
[67] Idris N M, Gnanasammandhan M K, Zhang J, Ho P C, Mahendran R, Zhang Y. Nat. Med., 2012, 18:1580.
[68] Ethirajan M, Chen Y H, Joshi P, Pandey R K. Chem. Soc. Rev., 2011, 40:340.
[69] Elmenoufy A H, Tang Y a, Hu J, Xu H, Yang X. Chem. Commun., 2015, 51:12247.
[70] Hu J, Tang Y A, Elmenoufy A H, Xu H, Cheng Z, Yang X. Small, 2015, 11:5860.
[71] Tang Y A, Hu J, Elmenoufy A H, Yang X. ACS Appl. Mater. Interfaces, 2015, 7:12261.
[72] Ma Y, Wan J, Qian K, Geng S, He N, Zhou G, Zhao Y, Yang X. J. Mater. Chem. B, 2014, 2:6044.
[73] Liu Y, Peng X, Qian K, Ma Y, Wan J, Li H, Zhang H, Zhou G, Xiong B, Zhao Y, Zheng C, Yang X. J. Mater. Chem. B, 2017, 5:907.
[74] Cai H, Li K, Li J, Wen S, Chen Q, Shen M, Zheng L, Zhang G, Shi X. Small, 2015, 11:4584.
[75] Liu S, Li H, Xia L, Xu P, Ding Y, Huo D, Hu Y. Biomaterials, 2017, 141:1.
[76] Chen J, Chen Q, Liang C, Yang Z, Zhang L, Yi X, Dong Z, Chao Y, Chen Y, Liu Z. Nanoscale, 2017, 9:14826.
[77] Lee K S, El Sayed M A. J. Phys. Chem. B, 2005, 109:20331.
[78] Liu X, Gao C, Gu J, Jiang Y, Yang X, Li S, Gao W, An T, Duan H, Fu J, Wang Y, Yang X. ACS Appl. Mater. Interfaces, 2016, 8:27622.
[79] Hu F, Zhang Y, Chen G, Li C, Wang Q. Small, 2015, 11:985.
[80] Dong L, Li Y, Li Z, Xu N, Liu P, Du H, Zhang Y, Huang Y, Zhu J, Ren G, Xie J, Wang K, Zhou Y, Shen C, Zhu J, Tao J. ACS Appl. Mater. Interfaces, 2018, 10:9247.
[81] Wang X, Wang H, Zhang Q, Cheng Y. Nanomed.-Nanotechnol. Biol. Med., 2016, 12:505.
[82] Song W, Wang D, Ren M, Li Y, Huang Z, Wei C, Yin W, Yang Q, Yang W. J. Biomed. Nanotechnol., 2017, 13:1158.
[83] Vijayaraghavan P, Liu C H, Vankayala R, Chiang C S, Hwang K C. Adv. Mater., 2014, 26:6689.
[84] Qin Z P, Bischof J C. Chem. Soc. Rev., 2012, 41:1191.
[85] Tang Y A, Yang T, Wang Q, Lv X, Song X, Ke H, Guo Z, Huang X, Hu J, Li Z, Yang P, Yang X, Chen H. Biomaterials, 2018, 154:248.
[86] Link S, Burda C, Mohamed M B, Nikoobakht B, El Sayed M A. J. Phys. Chem. A, 1999, 103:1165.
[87] Wang Z, Chang Z, Lu M, Shao D, Yue J, Yang D, Li M, Dong W f. ACS Appl. Mater. Interfaces, 2017, 9:30306.
[88] Rubio Ruiz B, Perez Lopez A M, Bray T L, Lee M, Serrels A, Prieto M, Arruebo M, Carragher N O, Sebastian V, Unciti Broceta A. ACS Appl. Mater. Interfaces, 2018, 10:3341.
[89] Song M, Liu N, He L, Liu G, Ling D, Su X, Sun X. Nano Res., 2018, 11:2796.
[90] Luo L, Bian Y, Liu Y, Zhang X, Wang M, Xing S, Li L, Gao D. Small, 2016, 12:4103.
[91] Wang F, Sun Q, Feng B, Xu Z, Zhang J, Xu J, Lu L, Yu H, Wang M, Li Y, Zhang W. Adv. Healthc. Mater., 2016, 5:2227.
[92] Volsi A L, Scialabba C, Vetri V, Cavallaro G, Licciardi M, Giammona G. ACS Appl. Mater. Interfaces, 2017, 9:14453.
[93] Wang X, Gao S, Qin Z, Tian R, Wang G, Zhang X, Zhu L, Chen X. ACS Appl. Mater. Interfaces, 2018, 10:15140.
[94] Zeng J Y, Zhang M K, Peng M Y, Gong D, Zhang X Z. Adv. Funct. Mater., 2018, 28:1705451.
[95] Zhao Y, Liu W, Tian Y, Yang Z, Wang X, Zhang Y, Tang Y, Zhao S, Wang C, Liu Y, Sun J, Teng Z, Wang S, Lu G. ACS Appl. Mater. Interfaces, 2018, 10:16992.
[96] Xu C, Chen F, Valdovinos H F, Jiang D, Goel S, Yu B, Sun H, Barnhart T E, Moon J J, Cai W. Biomaterials, 2018, 165:56.
[97] You Q, Sun Q, Yu M, Wang J, Wang S, Liu L, Cheng Y, Wang Y, Song Y, Tan F, Li N. ACS Appl. Mater. Interfaces, 2017, 9:40017.
[1] Shunxin Gu, Qin Jiang, Pengfei Shi. Antitumor Activity and Application of Luminescent Iridium(Ⅲ) Complexes [J]. Progress in Chemistry, 2022, 34(9): 1957-1971.
[2] Haidi Feng, Lu Zhao, Yunfeng Bai, Feng Feng. The Application of Nanoscale Metal-Organic Frameworks for Tumor Targeted Therapy [J]. Progress in Chemistry, 2022, 34(8): 1863-1878.
[3] Xiaofeng Chen, Kaiyuan Wang, Fangming Liang, Ruiqi Jiang, Jin Sun. Exosomes Drug Delivery Systems and Their Application in Tumor Treatment [J]. Progress in Chemistry, 2022, 34(4): 773-786.
[4] Bin Li, Ying Yu, Guoxiang Xing, Jinfeng Xing, Wanxing Liu, Tianyong Zhang. Progress in Circularly Polarized Light Emission of Chiral Inorganic Nanomaterials [J]. Progress in Chemistry, 2022, 34(11): 2340-2350.
[5] Jiali Wang, Ling Zhu, Chen Wang, Shengbin Lei, Yanlian Yang. Nanotechnology for Detection of Circulating Tumor Cells and Extracellular Vesicles [J]. Progress in Chemistry, 2022, 34(1): 178-197.
[6] Xiaodong Jing, Ying Sun, Bing Yu, Youqing Shen, Hao Hu, Hailin Cong. Rational Design of Tumor Microenvironment Responsive Drug Delivery Systems [J]. Progress in Chemistry, 2021, 33(6): 926-941.
[7] Huifeng Xu, Yongqiang Dong, Xi Zhu, Lishuang Yu. Novel Two-Dimensional MXene for Biomedical Applications [J]. Progress in Chemistry, 2021, 33(5): 752-766.
[8] Jiajia Wang, Huiying Wu, Renfeng Dong, Yuepeng Cai. Micro/Nanomotors on the Way to Intelligent Cancer Diagnosis, Delivery and Therapy [J]. Progress in Chemistry, 2021, 33(5): 883-894.
[9] Wenjie Liu, Kaihui Liu, Yanwei Zhang, Liang Wang, Mengyi Zhang, Jing Li. The Mechanism of Glycosylation in SARS-CoV-2 Infection and Application in Drug Development [J]. Progress in Chemistry, 2021, 33(4): 524-532.
[10] Jiawei Liu, Jing Wang, Qi Wang, Quli Fan, Wei Huang. Applications of Activatable Organic Photoacoustic Contrast Agents [J]. Progress in Chemistry, 2021, 33(2): 216-231.
[11] Xinyu Wang, Fuping Zhao, Ru Zhang, Ziru Sun, Shengnan Liu, Qingzhi Gao. Development of Hypoxia Inducible Factor-1 Small Molecule Inhibitors as Antitumor Agents [J]. Progress in Chemistry, 2021, 33(12): 2259-2269.
[12] Sha Tan, Jianzhong Ma, Yan Zong. Preparation and Application of Poly(3,4-ethylenedioxythiophene)∶Poly(4-styrenesulfonate)/Inorganic Nanocomposites [J]. Progress in Chemistry, 2021, 33(10): 1841-1855.
[13] Qixiao Guan, Heze Guo, Hongjing Dou. Nanocarriers Modified by Cell Membrane and Their Applications in Tumor Immunotherapy [J]. Progress in Chemistry, 2021, 33(10): 1823-1840.
[14] Shan Guo, Xiang Zhou. Detection of Circulating Tumor Cell in Vivo:Technology and Application [J]. Progress in Chemistry, 2021, 33(1): 1-12.
[15] Qing Wu, Yiyuan Tang, Miao Yu, Yueying Zhang, Xingmei Li. Stimuli-Responsive DNA Nanostructure Drug Delivery System Based on Tumor Microenvironment [J]. Progress in Chemistry, 2020, 32(7): 927-934.