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Progress in Chemistry 2019, Vol. 31 Issue (2/3): 413-421 DOI: 10.7536/PC180511 Previous Articles   Next Articles

Application of Inner Filter Effect Technology in Biological Detection and Disease Markers

Danbi Tian1,**(), Shengnan Wu1, Hao Zhang1, Ling Jiang2, Fengwei Huo3,**()   

  1. 1. College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
    2. College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China
    3. Institute of Advanced Materials, Nanjing Tech University, Nanjing 211816, China
  • Received: Online: Published:
  • Contact: Danbi Tian, Fengwei Huo
  • About author:
    ** E-mail: (Danbi Tian);
    (Fengwei Huo)
  • Supported by:
    Joint Funds of the National Natural Science Foundation of China(U1603112); Joint Funds of the National Natural Science Foundation of China(21574065); National Science Funds for Distinguished Young Scholars(21625401)
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As an important non-irradiation energy conversion model, the mechanism of inner filter effect(IFE) is that the absorption spectrum of the absorbers overlaps with the excitation spectrum or emission spectrum or both spectra of the fluorophor, resulting in the fluorescence quenching of the excitation peak/emission peak of the fluorophor. The suitable donor-acceptor pair is a significant factor for successfully constructing IFE sensors to detect targets. In recent years, IFE technology has been widely studied by researchers because of its simple operation, high sensitivity, no need to modify donor and link donor and receptor. Disease is a serious threat to people’s health. Early diagnosis and early treatment are the most effective ways to prevent disease and protect health. This review summarizes the research results of IFE technology in recent years for detecting enzyme activities, pesticides, metabolites and small molecular chemicals on disease markers and health monitoring, and explains the unique design of IFE sensors based on "turn-off", "turn-on“and “ratiometric fluorescence assay” method. The advantages and disadvantages of each method are also discussed. Finally, the advantages and practical obstacles of IFE technology in disease labeling and health monitoring are briefly pointed out, and the prospects for the future development of IFE technology and disease surveillance methods are also prospected.

Key words: inner filter effect(IFE), disease markers, enzyme activity, pesticides, metabolites
Fig. 1 Three analytical strategies based on IFE to detect analytes:(A) Turn off mode;(B) Turn on mode;(C) Ratiometric fluorescence assay mode
Fig. 2 Working principle for ALP sensing based on inner filter effect[49]
Table 1 Turn off mode-based analytical assays for various enzymes
Analyte Donor Receptor Detection limit Linear range Real sample ref
ALP N-doped CDs PNP 0.01~25 U/L 0.001 U/L Serum samples, inhibitor 49
ALP N/B-dots PNP 0.003~5.5 U/L 0.3 mu/L / 50
ALP PSGNC PNP 0.0312~1 U/L 1.616 U/L Serum samples 51
GLU N-doped CDs PNP 1~60 U/L 0.3 U/L Serum samples, inhibitor 52
a-glucosidase N-doped CDs PNP 10-3~10-7M 10-8 M Inhibitor 53
Fig. 3 Principle of ALP detection based on inner filter effect[55]
Fig. 4 Schematic illustration of N/Cu-CDs synthesis and the principle of the ratiometric fluorescence universal platform based on N/Cu-CDs to detect the metabolites(cholesterol and xanthine) participating in H2O2-generation reactions[98]
Table 2 Detection of common small molecular chemicals based on fluorescence filter effect
Materials Donor Acceptor Mode of assay ref
GSH g-C3N4 Cp Turn on 104
GSH TMPyP oxTMB Turn on 105
GSH N-doped CDs TNB Turn off 106
AA CdTe QDs AgNPs Turn off 107
AA N-CNPs ascorbic acid Turn off 108
DA GQDs AuNPs Turn on 109
vitamin B12 carbon dots vitamin B12 Turn off 110
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