中文
Earlier issues
Announcement
More
Progress in Chemistry 2018, Vol. 30 Issue (11): 1692-1700 DOI: 10.7536/PC180432 Previous Articles   Next Articles

• Review •

Application of Polyetheretherketone in the Orthopedic Implants

Jing Ma, Bin Tang*   

  1. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the Shenzhen Basic Research Project(No.JCYJ20160517160827379), the Individual Maker Project(No.GRCK20160829195523424), and Shenzhen Basic Research Layout Project(No.JCYJ20170817111312887).
PDF ( 890 ) Cited
Export

EndNote

Ris

BibTeX

Polyetheretherketone (PEEK) has been demonstrated to have superior mechanical properties, wear resistance, chemical resistance, and good biocompatibility. Moreover, its elastic modulus is comparable to human bone, and PEEK has excellent radiolucency, is easy to be processed and can be repeatedlysterilized. These outstanding features make PEEK a promising bone-implant material. PEEK now is one of potential candidates for replacing the conventional implant materials including stainless steel, titanium alloys, ultra high molecular weight polyethylene and even biodegradable materials in orthopedic implant applications. However, the bioinertness of PEEK limit its clinical application. To obtain good bone-implant interfaces, quite a number of techniques have been developed to enable PEEK and PEEK-based composites from bio-inert to bioactive. Initially, the bioactive ceramics (such as hydroxyapatite, β-tricalcium phosphate, amorphous magnesium phosphate and calcium silicate) were added into the PEEK matrix through mechanical blending methods. These fillers have been found to significantly improve the bioactivity of PEEK composites at the expense of tensile strength. At present, many efforts have been done in fabrication of ternary composite, which is simultaneously incorporating bioactive ceramics and reinforced fiber into PEEK. The PEEK-based ternary composites enhanced both biomechanical properties and bioactivity of PEEK-based composites. Moreover, introducing porosity into PEEK manufactures porous PEEK, which provides available porosity for bone ingrowth. In this paper, the changes of the biomechanical properties and bioactivity of porous-PEEK, PEEK binary composites and PEEK ternary composites are summarized. The potential clinical applications are also reviewed according to the biomechanics and bioactivity of these PEEK-based composites. It is expected that this paper should provide a theoretical basis for fabricating PEEK-based orthopedic implants with biomechanics similar to human bone, good biocompatibility and biological safety and promote the application of PEEK and PEEK-based composites in orthopedic implants.
Contents
1 Introduction
2 Porous PEEK
3 PEEK-based binary composites
3.1 PEEK/hydroxyapatite composite
3.2 PEEK/other bioactive ceramics
3.3 PEEK/carbon fiber composites
3.4 PEEK/growth factor composites
4 PEEK-based ternary composites
5 Conclusion
Key words: polyetheretherketone, porous PEEK, PEEK-based binary composites, PEEK-based ternary composites

CLC Number: 

[1] Kurtz S M, Devine J N. Biomaterials, 2007, 28(32):4845.
[2] Liu X, Han F, Zhao P, Lin C, Wen X, Ye X. Nanomedicine, 2017, 13(4):1423.
[3] Du Y W, Zhang L N, Hou Z T, Ye X, Cu H S, Yan G P, Shang P. Front. Mater. Sci., 2014, 8(4):313.
[4] Najeeb S, Zafar M S, Khurshid Z, Siddiqui F. J. Prosthodontic Res., 2015, 60(1):12.
[5] Abdullah M R, Goharian A, Abdul Kadir M R, Wahit M U. Journal of Biomedical Materials Research Part A, 2015, 103(11):3689.
[6] 刘昌胜(Liu C S). 硬组织修复材料与技术(Materials and techniques of hard tissue repair).北京:科学出版社(Bei Jing:Science Press), 2015. 190.
[7] Evans N T, Torstrick F B, Lee C S D, Dupont K M, Safranski D L, Chang W A, Macedo A E, Lin A S P, Boothby J M, Whittingslow D C, Carson R A, Guldberg R E, Gall K. Acta Biomaterialia, 2015, 13:159.
[8] Evans N T, Torstrick F B, Safranski D L, Guldberg R E, Gall K. J. Mechanical Behavior of Biomedical Mater., 2016, 65:522.
[9] Vaezi M, Black C, Gibbs D M, Oreffo R O, Brady M, Moshrefi-Torbati M, Yang S. Molecules, 2016, 21(6):687.
[10] Li Q, Zhang Y, Wang D, Wang H, He G. Materials & Design, 2017, 116:171.
[11] Abu Bakar M S, Cheng M H, Tang S M, Yu S C, Liao K, Tan C T, Khor K A, Cheang P. Biomaterials, 2003, 24(13):2245.
[12] Abu Bakar M S, Cheang P, Khor K A. Composites Science & Technology, 2003, 63(3/4):421.
[13] Bakar M S A, Cheang P, Khor K A. Materials Science & Engineering A, 2003, 345(1):55.
[14] Converse G L, Yue W, Roeder R K. Biomaterials, 2007, 28(6):927.
[15] Pan Y S, Shen Q Q, Chen Y, Yu K, Pan C L, Zhang L. Materials & Processing Report, 2014, 30(5):257.
[16] Wang L, Weng L, Song S, Sun Q. Materials Letters, 2010, 64(20):2201.
[17] Wang L, Weng L, Song S, Zhang Z, Tian S, Ma R. Materials Science & Engineering A, 2011, 528(10/11):3689.
[18] Ma R, Weng L, Fang L, Luo Z, Song S. Journal of Sol-Gel Science and Technology, 2012, 62(1):52.
[19] Ma R, Weng L, Bao X, Ni Z, Song S, Cai W. Materials Letters, 2012, 71:117.
[20] Chan K W, Liao C Z, Wong H M, Yeung K W K, Tjong S C. RSC Advances, 2016, 6(23):19417.
[21] Pors N S. Bone, 2004, 35(3):583.
[22] Wong K L, Wong C T, Liu W C, Pan H B, Fong M K, Lam W M, Cheung W L, Tang W M, Chiu K Y, Luk K D, Lu W W. Biomaterials, 2009, 30(23/24):3810.
[23] Wang L, He S, Wu X, Liang S, Mu Z, Wei J, Deng F, Deng Y, Wei S. Biomaterials, 2014, 35(25):6758.
[24] Petrovic L, Pohle D, Münstedt H, Rechtenwald T, Schlegel K A, Rupprecht S. Journal of Biomedical Science, 2006, 13(1):41.
[25] Nabiyouni M, Ren Y, Bhaduri S B. Materials Science and Engineering:C, 2015, 52:11.
[26] Ren Y, Sikder P, Lin B, Bhaduri S B. Materials Science and Engineering:C, 2018, 85:107.
[27] Ding J, Shie M Y, Wei C K. ACS Appl. Mater. Interfaces, 2011, 3(10):4142.
[28] Wang C, Lin K, Chang J, Sun J. Journal of Biomedical Materials Research Part A, 2014, 102(7):2096.
[29] Fei L, Chen W, Yang X, Lin K, Jiang C, Jiao S. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2012, 100B(5):1237.
[30] Kim I Y, Sugino A, Kikuta K, Ohtsuki C, Cho S B. Journal of Biomaterials Applications, 2009, 24(2):105.
[31] Ma R, Tang S, Tan H, Qian J, Lin W, Wang Y, Liu C, Wei J, Tang T. ACS Appl. Mater. Interfaces, 2014, 6(15):12214.
[32] Kuo M C, Tsai C M, Huang J C, Chen M. Materials Chemistry & Physics, 2005, 90(1):185.
[33] Luo H, Xiong G, Yang Z, Raman S R, Li Q, Ma C, Li D, Wang Z, Wan Y. Journal of the Mechanical Behavior of Biomedical Materials, 2014, 29(1):103.
[34] Qiu X, He F, Li J, Chen L, Huang Y. Polymer Composites, 2016, 36(12):2174.
[35] Brockett C L, John G, Williams S Jin Z, Isaac G H, Fisher J. J Biomed. Mater. Res. B Appl. Biomater., 2012, 100B(6):1459.
[36] Toth J M, Wang M, Estes B T, Scifert J L, Rd S H, Turner A S. Biomaterials, 2006, 27(3):324.
[37] Du Y W, Zhang L N, Ye X, Nie H M, Hou Z T, Zeng T H, Yan G P, Shang P. Frontiers of Materials Science, 2015, 9(1):38.
[38] Feng X, Sui G, Yang R. Chinese Journal of Materials Research, 2008, 22(1):18.
[39] Liu X Y, Liu J Q, Deng C B, Dong-Chao W U, Sui G X. Biomedical Engineering & Clinical Medicine, 2010, 11(6):481.
[40] Deng Y, Zhou P, Liu X, Wang L, Xiong X, Tang Z, Wei J, Wei S. Colloids & Surfaces B Biointerfaces, 2015, 136:64.
[41] Han C T, Chi M, Zheng Y Y, Jiang L X, Xiong C D, Zhang L F. J. Polym. Res., 2013, 20:203.
[42] von Wilmowsky C, Vairaktaris E, Pohle D, Rechtenwald T, Lutz R, Munstedt H, Koller G, Schmidt M, Neukam F W, Schiegel K A, Nkenke E. Journal of Biomedical Materials Research Part A, 2008, 87(4):896.
[43] Molazemhosseini A, Tourani H, Khavandi A, Yekta B E. Wear, 2013, 303(1/2):397.
[44] Tourani H, Molazemhosseini A, Khavandi A, Mirdamadi S, Shokrgozar M A, Mehrjoo M. Polymer Composites, 2013, 34(11):1961.
[1] Lvhua Liu, Yanyan Zheng*, Lifang Zhang, Chengdong Xiong. Bioactive Polyetheretherketone Implant Composites for Hard Tissue [J]. Progress in Chemistry, 2017, 29(4): 450-458.