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Progress in Chemistry 2018, Vol. 30 Issue (5): 692-702 DOI: 10.7536/PC180324 Previous Articles   

• Review •

Biosynthetic Mechanisms of Alkaloids from Actinomycetes

Tingting Huang, Zihua Zhou, Qi Liu, Xiaozheng Wang, Wenli Guo, Shuangjun Lin*   

  1. State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21632007).
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Alkaloid natural products generally have complex and diverse chemical structures and exhibit a wide range of biological activities, and therefore are of great interest to biologists, chemists, and pharmacists. Apart from plants, microorganisms have been identified as the most important source of natural alkaloids. Microorganisms, especially actinomycetes, produce many secondary metabolites including alkaloids. Studies on the biosynthesis of skeletons and pharmacophores of alkaloids produced by actinomycetes not only enrich our understanding of the biosynthetic mechanism of natural products, but also provide important genetic elements in order to generate these compounds or the derivatives by designed and man-made synthetic pathways in heterologous host using synthetic biology. This review provides a summary of recent research advances in elucidating the biosynthesis of alkaloids from actinomycetes. The detailed biochemical mechanisms have been summarized in modular biosynthetic machineries and non-modular enzymatic systems, respectively.
Contents
1 Introduction
2 Modular biosynthesis of alkaloids
2.1 Diketopiperazine alkaloids
2.2 Pyrrolobenzodiazepines
2.3 Tetrahydroisoquinolines
2.4 Maremycins family
3 Non-modular biosynthesis of alkaloids
3.1 Streptonigrinoids
3.2 Spirocycloproprane family
3.3 Indolocarbazole alkaloids
3.4 Aminobenzoquinone-aziridine alkaloids
4 Conclusion and outlook
Key words: actinomycetes, natural product, alkaloid, biosynthetic pathway, enzymatic reaction

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