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Progress in Chemistry 2018, Vol. 30 Issue (8): 1112-1120 DOI: 10.7536/PC171222 Previous Articles   Next Articles

• Review •

Preparation Technologies of the Polymer-Based MONOLITH Material and Its Application as Stationary Phase of Affinity Chromatography for the Separation of Biological Macromolecules

Ying Xu1, Tingting Gao1, Qixiao Wang1, Yang Qu1, Hongfei Liu1, Yuanrong Xin1,2*   

  1. 1. School of Pharmacy, Jiangsu University, Zhenjiang 212013, China;
    2. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 51703086, 81602656), the Jiangsu Provincial Natural Science Foundation(No. BK20160496, BK20160546), the Postdoctoral Science Foundation(No. 2017M610309), and the Training Project for Young Key Teachers.
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In recent years, a newly emerging polymer-based MONOLITH material (also known as the monolithic column, continuous bed) has been developed rapidly and it has already been utilized widely in various fields. Due to its unique three-dimensional continuous interconnected porous structure in a single piece, polymer-based MONOLITH has attracted more and more attention and it is regarded as one of the major breakthroughs in separation and filtration techniques. Compared with silica-based MONOLITH material, polymer-based MONOLITH material has the advantages of simple preparation process, good biocompatibility, high chemical stability and easy regulation of surface chemical properties. Therefore, polymer-based MONOLITH has always done a better job as a stationary phase of affinity chromatography for separating and analyzing biological macromolecules. In this review, the preparation techniques and the newest development of the polymer-based MONOLITH material are summarized. In addition, its application as stationary phase of affinity chromatography for the separation of biological macromolecules in the last 5 years is described.
Contents
1 Introduction
2 Preparation techniques of the polymer-based MONOLITH materials
2.1 Free radical polymerization
2.2 Controlled/living radical polymerization
2.3 Polymerized high internal phase emulsions
2.4 Condensation polymerization
2.5 Cryogels
2.6 Other methods
3 Application of the polymer-based MONOLITH materials in separation of biomolecules by affinity chromatography
3.1 Bioaffinity chromatography
3.2 Immunoaffinity chromatography
3.3 Dye affinity chromatography
3.4 Boronate affinity chromatography
3.5 Immobilized metal-ion affinity chromatography
3.6 Pseudo affinity chromatography
4 Conclusion
Key words: polymer-based MONOLITH material, preparation techniques, affinity chromatography, stationary phase, biomacromolecules

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