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Progress in Chemistry 2017, Vol. 29 Issue (12): 1480-1487 DOI: 10.7536/PC170703 Previous Articles   Next Articles

• Review •

Stimuli-Responsive Polymers in Biomedical Applications

Zicheng Li, Gongke Li*, Yuling Hu*   

  1. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
  • Received: Revised: Online: Published:
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (No. 21675178, 21475153, 21575168), the Guangdong Provincial Natural Science Foundation (No. 2015A030311020, 2016A030313358), the Special Funds for Public Welfare Research and Capacity Building in Guangdong Province of China (No. 2015A030401036), and the Guangzhou Minsheng Science and Technology Major Project of China (No.201604020165).
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Stimuli-responsive polymers are capable of exhibiting reversible or irreversible changes in physical and/or chemical properties in response to small changes in external environment, such as pH, ions, temperature, light, etc. In recent years, stimuli-responsive polymers have been widely used in disease diagnosis, drug delivery, and sensors. Depending on the type of the external stimuli, stimuli-responsive polymers can be classified into several categories. This article reviews the synthesis methods and the mechanism of the stimuli-responsive polymers based on the chemical stimulation, physical stimulation and biological stimulation. Furthermore, the long-term prospect and the potential applications of these functional materials are introduced.
Contents
1 Introduction
2 Chemical stimulation
2.1 pH-responsive polymers
2.2 Gas-responsive polymers
2.3 Ion-responsive polymers
3 Physical stimulation
3.1 Thermo-responsive polymers
3.2 Electric-responsive polymers
3.3 Photo-responsive polymers
4 Biological stimulation
4.1 Glucose-responsive polymers
4.2 Nucleic acids-responsive polymers
4.3 Enzyme-responsive polymers
5 Conclusion
Key words: stimuli-responsive, polymers, drug delivery, sensors

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