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Progress in Chemistry 2017, Vol. 29 Issue (1): 13-14 DOI: 10.7536/PC161238 Previous Articles   Next Articles

Special Issue: 中国化学印记

• Imprint of Chinese Chemistry •

Enantioselective Cyanation of Benzylic C-H Bonds via Copper-Catalyzed Radical Delay

Kuiling Ding*   

  1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
  • Online: Published:
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C-H bond functionalization refers to transformations that introduce functional group directly via the cleavage of C-H bond, which shows excellent step- and atom-economy. A recent breakthrough was achieved by the Guosheng Liu group in collaboration with Shannon S. Stahl group from University of Wisconsin-Madison. They discovered a new strategy to achieve Cu-catalyzed enantioselective cyanation of benzylic C-H bonds via a "Radical Relay Process". The present copper-catalyzed method provides a remarkably chemo-, regio- and enantioselectivity to afford optical organonitriles efficiently under mild reaction conditions.
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