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Progress in Chemistry 2017, Vol. 29 Issue (4): 348-358 DOI: 10.7536/PC161217 Previous Articles   Next Articles

• Review •

Biomolecular Responsive Polymer Materials

Hongxi Wang, Yuting Xiong, Guangyan Qing*, Taolei Sun*   

  1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 51473131, 21275114, 51533007, 51521001).
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Among smart polymer materials,biomolecule-responsive polymer is capable of responding to the binding/releasing of biological molecules, for example saccharides, peptides, enzymes, which resulting in dramatic transition in macroscopic properties of materials, such as volume, surface wettability and stiffness. These materials include hydrogels, copolymer films and some other types. The response process between material and biomolecules is generally realized by hydrogen bonds, intermolecular forces and other weak interactions. Due to their excellent designability and good biocompatibility, biomolecule-responsive polymers have many application prospects in biomedical fields such as biosensing, tissue engineering, microfluidic devices, bioseparation and so on, which have attracted more and more interests. Compared with many traditional exogenous stimuli, such as temperature, pH, magnetic field, electric field, or light irradiation, biomolecule-responsive polymers have better targeting ability. Therefore, they can better satisfy the high demand of biomaterials applied in vivo. Furthermore, biomolecule-responsive materials can be developed to the new generation of material for disease diagnosis and drug controllable release. Herein, according to the categories of biomolecules, like saccharides, proteins, enzymes and DNA, the design and response mechanism of biomolecule-responsive polymers materials has been summarized and the applications of these materials are also introduced. Finally, the research prospect of these fields are proposed.

Contents
1 Introduction
2 Saccharides-responsive
3 Protein-responsive
4 Enzyme-responsive
5 DNA-responsive
6 Conclusion

CLC Number: 

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Abstract

Biomolecular Responsive Polymer Materials