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Progress in Chemistry 2017, Vol. 29 Issue (2/3): 300-317 DOI: 10.7536/PC160929 Previous Articles   Next Articles

• Review •

Design Strategies and Applications of Quantum Dots Fluorescent Sensing

Xianyun Hu1,2*, Qingsheng Guo1, Yuqian Liu1, Qingjiang Sun1*, Tiehong Meng2, Ruguo Zhang2   

  1. 1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China;
    2. Qiannan Medical College for Nationalities, Duyun 558000, China
  • Received: Revised: Online: Published:
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (No. 21545006,21375015), the National Science Foundation of Guizhou Province (No. 2015GZ48861, 2016GZ13752), the Fundamental Research Funds for the Central Universities (No. KYLX0187) and the Scientific Research fund of Qiannan Medical College for Nationalities (No.QNYZ201601).
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Quantum dots (QDs), as novel fluorescent nanomaterials, have been widely used in fluorescent sensing and visual detection with high sensitivity and specificity analysis of target, owing to their excellent optical and electrical properties. The review addresses the surface functionalization of QDs that able to the use of sensing, and discusses different sensing mechanism including fluorescence resonance energy transfer (FRET), electron transfer (CT), direct fluorescent sensing, bioluminescence resonance energy transfer (BRET), chemiluminescence resonance energy transfer (CRET) and electrochemiluminescence (ECL), being applied in the different sensing systems. The challenges and existing problems of QDs fluorescent sensing application are summarized. Meanwhile fluorescent sensing of QDs will develop in the field of the good biocompatibility, real time visualization of sensing in cells or in vivo, multiplexed detection in complex systems and the function of sensing with logic-gate operations in the future.

Contents
1 Introduction
2 Photo-properties of quantum dots
3 Surface chemistry and conjugates of quantum dots
4 Mechanisms and design strategies of quantum dots fluorescence sensing
4.1 Fluorescence resonance energy transfer
4.2 Electron transfer
4.3 Direct fluorescent sensing
4.4 Bioluminescence resonance energy transfer
4.5 Chemiluminescence resonance energy transfer
4.6 Electrochemiluminescence
5 Conclusion

Key words: quantum dots, fluorescent sensing, probe, visualization detection

CLC Number: 

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