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Progress in Chemistry 2016, Vol. 28 Issue (8): 1196-1206 DOI: 10.7536/PC160212 Previous Articles   Next Articles

• Review and comments •

Synthesis and Application of Polyaspartamide Derivatives for Drug/Gene Delivery

Fu Kaiqiao1*, Zhang Guangyan1*, Jiang Xulin2   

  1. 1. Hubei Provincial Key Laboratory of Green Materials for Light Industry, Department of Light Industry, Hubei University of Technology, Wuhan 430068, China;
    2. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No.21174109, 21374083) and the Doctoral Scientific Research Foundation of Hubei University of Technology (No. BSQD14003)
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Compared with carbon-chain polymers, poly(amino acid)s have attracted much attentions in biomedical and pharmaceutical fields because of their good biocompatibility, biodegradability and nontoxicity. Polyaspartamide derivatives based on L-aspartic acid not only can be easily synthesized, but also can be further modified with various structures to prepare intelligent material with different stimuli-responsivity (such as temperature, pH and redox), resulting in controlled release, enhancement of therapeutic effects and reduction of the drug side effects. In this review, the different synthetic strategies for preparing polyaspartamide derivatives and the up-to-date developments on polyaspartamide derivatives for drug and gene delivery systems are summarized. Besides, the future perspectives of polyaspartamide derivatives are discussed.

Contents
1 Introduction
2 Synthesis of polyaspartamide derivatives
2.1 Aminolysis reaction of PSI
2.2 ROP of N-carboxyanhydride
3 Application of polyaspartamide derivatives
3.1 Drug delivery
3.2 Gene delivery
4 Outlook

Key words: polyaspartamide derivatives, drug delivery, gene delivery, stimuli-responsivity

CLC Number: 

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