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Progress in Chemistry 2016, Vol. 28 Issue (6): 954-960 DOI: 10.7536/PC151218 Previous Articles   Next Articles

• Review and comments •

Targeting Carrier/Gene Complexes to Promote the Proliferation of Endothelial Cells

Liu Wen1, Zhang Li2, Yang Jing1, Hao Xuefang1, Li Qian1, Feng Yakai1,2*   

  1. 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 30007;
    2. Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Tianjin 300072, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 31370969) and the Ministry of Science and Technology of China(No.2013DFG52040).
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Due to the lack of a living functional layer of endothelial cells (ECs) on the surface of artificial vascular scaffolds, especially small-diameter artificial vascular scaffolds, usually encounter long-term low patency and restenosis, limiting their clinical application. Nevertheless, it has been proved that re-endothelialization of artificial vascular scaffolds can be aquired rapidly via gene transfection towards endothelial cells, which is mediated by gene complexes. At present, gene carriers modified with targeting peptides provide a useful approach to promote transfection efficiency as well as decrease cytotoxicity. We introduce the desired genes and gene carriers applied in gene transfection detailedly. Based on polycationic gene carriers, the recent developments of gene carriers with targeting peptides for promoting the proliferation of ECs and endothelialization are highlighted in this review. Combined with the progress of small diameter artificial blood vessels, some perspectives on accomplishing rapid endothelialization via gene transfection are also presented.

Contents
1 Introduction
2 Non-viral gene carriers
3 Peptides for selective adhesion of endothelial cells
4 Gene carriers for targeting transfection of endothelial cells
5 Artificial vascular scaffolds modified by targeting carrier/gene complexes
6 Conclusion and outlook

Key words: artificial vascular scaffolds, gene carrier, targeting, polycationic, endothelialization

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