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Progress in Chemistry 2016, Vol. 28 Issue (6): 829-838 DOI: 10.7536/PC151130 Previous Articles   Next Articles

• Review and comments •

The Continuous Flow Micro-Reaction

He Tao, Ma Xiaobo, Xu Zhihong, Wang Zhouyu*   

  1. Department of Chemistry, Xihua University, Chengdu 610039, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21102115 ) and the Great Cultivate Project from the Education Department of Sichuan Province (No.14CZ0014)
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In recent centuries, the traditional tank reaction provides a large number of chemical products thermolysis of azidoacrylates. However, potential safety hazard, environmental pollution, huge energy consumption, huge site area and scale-up difficulties are the shortcomings. Continuous flow micro-reactor, with its high efficient heat transfer and mass transfer, accurate temperature control, security and stability, no amplification effect and the advantages of real-time monitoring, can solve the problems which existing in the traditional reaction. This review focuses on new findings in continuous flow micro-reaction in the last five years. The nitration reaction, thermolysis of azidoacrylates, Grignard and Grignard-type reactions, coupled reaction, amination reaction, oxidation and reduction reaction, condensation reaction, cyclization reaction, multistep reaction in flow condition and the continuous flow micro-reactors are introduced. Meanwhile, the potential strengths of the continuous flow micro-reaction as well as the weaknesses are discussed.

Contents
1 Introduction
2 Liquid phase reaction in flow condition
2.1 Nitration reaction
2.2 Thermolysis of azidoacrylates
2.3 Grignard and Grignard-type reaction
2.4 Coupled reaction
2.5 Amination reaction
2.6 Oxidation and Reduction reaction
2.7 Condensation reaction
2.8 Cyclization reaction
2.9 Other reactions
3 The gas-liquid reaction and gas-liquid-solid reaction in flow condition
4 Multistep reaction in flow condition
5 The continuous flow micro-reactors
6 Others
7 Conclusion

Key words: continuous flow, micro reaction, traditional tank reaction, high heat transfer and mass transfer, amplification effect

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Abstract

The Continuous Flow Micro-Reaction