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Progress in Chemistry 2016, Vol. 28 Issue (4): 552-563 DOI: 10.7536/PC151031 Previous Articles   Next Articles

• Review and comments •

Preparation and Applications of Core-Shell Molecularly Imprinted Polymers

Ming Weina1,2, Wang Xiaoyan2,3, Ming Yongfei4, Li Jinhua2, Chen Lingxin1,2*   

  1. 1. Key Laboratory of Life-Organic Analysis of Shandong Province, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China;
    2. Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003;
    3. School of Pharmacy, Binzhou Medical University, Yantai 264003, China;
    4. School of Life Science, Ludong University, Yantai 264025, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 21275158, 21477160).
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Molecularly imprinted polymers (MIPs) are a new kind of smart polymers with molecular recognition sites complementary to the template molecules in shape, size and functional groups. MIPs can selectively recognize and effectively concentrate target analytes (template molecules) as well as reduce matrices interferences, and they have been widely applied in many fields such as sample pretreatment, chemical/biological sensors, and drug delivery. However, there are still some problems during the traditional synthesis processes of MIPs, such as incomplete template removal, low binding capacity, slow mass transfer and binding kinetic. Surface imprinting is a very effective way to solve the problems, and the resultant core-shell MIPs have cavities at the polymer surface or close to the surface, which can facilitate the elution and diffusion of the template molecules, and increase effective recognition sites and improve imprinting capacities. This review summarizes several types of core-shell MIPs including magnetic core and non-magnetic core, focusing on their preparation and applications. Also, the preparation and development of hollow core-shell MIPs are discussed. Finally, the future outlook of core-shell MIPs is proposed.

Contents
1 Introduction
2 Core-shell molecularly imprinted polymers
2.1 Magnetic core-shell MIPs
2.2 Non-magnetic core-shell MIPs
3 Hollow core-shell MIPs
4 Conclusion and outlook

Key words: molecularly imprinted polymers, core-shell, surface imprinting, magnetic core

CLC Number: 

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