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Progress in Chemistry 2016, Vol. 28 Issue (1): 67-74 DOI: 10.7536/PC150643 Previous Articles   Next Articles

• Review and comments •

Regulation the Morphology of Micro-and Nanoparticles and the Effect on Drug/Gene Delivery System

Liu Yajie, Zhang Peng, Du Jianwei, Wang Youxiang*   

  1. Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21474087, 51273177).
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Supramolecular assembly has greatly promoted the development of drug/gene delivery system, due to the suitable micrometer or nanometer size, controllable structure and excellent biocompatibility. Recent studies have found that the topological structure plays a critical role in the drug/gene delivery process, which attracts great interest of researchers. In this paper, the main factors that regulate the morphology of micro-and nanoparticles are discussed, which mainly include composition of the copolymer, condition of self-assembly, external stimuli and polymerization-induced self-assembly. Then the effect of morphology on drug/gene delivery, challenges and prospects in this area are also discussed at the end of this review.

Contents
1 Introduction
2 Main methods of morphology regulation
2.1 Effect of the copolymer composition
2.2 Effect of self-assembly condition
2.3 Effect of external stimuli
2.4 Polymerization-induced self-assembly
3 The effect of morphology of drug/gene delivery system on blood circulation time and cell uptake
4 Conclusion

Key words: micro-and nanoparticles, self-assembly, morphology regulation, drug/gene vector

CLC Number: 

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