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Progress in Chemistry 2015, Vol. 27 Issue (12): 1784-1798 DOI: 10.7536/PC150629 Previous Articles   Next Articles

• Review and comments •

Stimuli-Responsive Degradable Polymeric Hydrogels

Cheng Xinfeng1,2, Jin Yong3,4*, Qi Rui1,2, Fan Baozhu1,2, Li Hanping3,4   

  1. 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;
    2. University of Chinese Academy of Sciences, Beijing 100049, China;
    3. Key Laboratory for Leather Chemistry and Engineering of the Education Ministry, Sichuan University, Chengdu 610065, China;
    4. National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National High-Tech Research and Development Projects (863) (No. 2013AA06A306), the National Natural Science Foundation of China (No. 21474065), and the Sichuan Province Leaders in Academic and Technical Training Project Funding (No. 2015/100-5).
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Polymeric hydrogels, as an important class of polymeric materials, have found widespread use in biomedical and pharmaceutical fields due to their excellent physicochemical and biological characteristics. Degradability is an important parameter when considering the application of polymeric hydrogels in the biomedical fields. Stimuli-responsive degradable (SRD) hydrogel is a kind of intelligent materials, whose network structure can be cleaved in response to external environmental triggers, resulting in a gel-sol or swelling-degradation transition behavior. The stimuli-responsive degradability can be realized by incorporation of environment-sensitive labile or cleavable groups into the gel network. Moreover, this characteristic SRD ability has attracted tremendous interests due to the triggered and controlled degradability in space or in time as compared to the conventional hydrolysis and enzymolysis. This review mainly focuses on the design methods, mechanisms of degradation and most recent studies of SRD hydrogels whose bonds responsively broken by pH, photo and redox triggers. Finally, a perspective on the future research directions of the SRD hydrogels is briefly discussed.

Contents
1 Introduction
2 Stimuli-responsive degradable polymeric hydrogels
2.1 pH-responsive degradable polymeric hydrogels
2.2 Photo-responsive degradable polymeric hydrogels
2.3 Redox-responsive degradable polymeric hydrogels
2.4 Others
3 Conclusion and outlook

Key words: polymeric hydrogel, stimuli-responsive degradation, cleavable groups, biomaterials

CLC Number: 

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