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Progress in Chemistry 2016, Vol. 28 Issue (1): 75-82 DOI: 10.7536/PC150615 Previous Articles   Next Articles

• Review and comments •

Fabricating Polymer Microspheres through CaCO3 Templates

Wang Rongmin*, Lv Siyao, Li Tao, He Yufeng, Song Pengfei   

  1. Key Laboratory Eco-Environment-Related Polymer Materials of Ministry of Education, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21263024, 21364012).
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Templating technique is an effective and efficient method to fabricate polymer microspheres with controllable size and same morphology. As one of polymorphs of CaCO3, vaterite is the ideal template particle for fabricating microspheres because of many advantages such as their biocompatibility, monodispersed pore size and mild decomposition conditions. In this review, based on introducing the CaCO3 templates briefly, a recent progress in utilizing the CaCO3 templates for fabricating microspheres is also addressed according to the selection of raw materials and the applications. Three main routes to load the CaCO3 cores have been used, such as physisorption, infiltration and co-precipitation. The raw materials can be divided into natural polymer (such as polysaccharide, protein and DNA) and synthetic polymer (such as polystyrene sulfonate, polyvinyl alcohol). The structures of microspheres fabricated by CaCO3 templates are porous and hollow, and size controlling with uniform morphology. All the particles can be used in various areas included pharmaceutical, drug delivery, biosensors and chemical analysis. In the future, the researches of CaCO3 templating technique will be greatly promoted by the development of nanotechnology and the requirement of biomedical field to prepare the new kinds of microspheres with extensive applications.

Contents
1 Introduction
2 The introduction of CaCO3 templates
3 Natural polymer microspheres
3.1 Chitosan microcapsules and alginate microcapsules
3.2 Protein and polyaminoacid porous microspheres
3.3 DNA microcapsules
4 Synthetic polymer microspheres
4.1 The polymer microspheres containing polystyrene
4.2 Polyethylene glycol porous microspheres
5 Conclusion

Key words: polymer microsphere, calcium carbonate template, porous microsphere, microcapsule, carrier material

CLC Number: 

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