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Progress in Chemistry 2015, Vol. 27 Issue (10): 1413-1424 DOI: 10.7536/PC150408 Previous Articles   Next Articles

• Review and comments •

Peptide-Mediated Supramolecular Helical Polymers

Wang Jun1,3, Zhang Afang1,2*   

  1. 1. School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China;
    2. Qianweichang School, Shanghai University, Shanghai 200444, China;
    3. School of Pharmacy, Jining Medical College, Rizhao 276800, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the State Key Program of National Natural Science Foundation of China (No. 21034004), the National Natural Science Foundation of China (No. 21374058, 21574078), the PhD Programs Foundation of the Ministry of Education of China (No. 201331081100166), and the Higher School Young Backbone Teacher Visiting Scholar Program of Shandong Province.
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Combining the dynamic and tunable characteristics from supramolecular polymers and the helical conformation from chiral polymers, supramolecular helical polymers have received considerable research interest and been widely applied in various fields, including chiral probes and chiral recognition, as well as asymmetric catalysis. Peptides integrate chirality, abandoned secondary structures, and high tendency to self-assemble, which have been used for mediating supramolecular formation of helical polymers. In the present review, peptide-mediated supramolecular helical polymers will be described in details, focusing on structural effects of different peptides on supramolecular formation and chirality enhancement. By comparison to linear peptides, topology of their representatives, including cyclopeptides, dendritic and C3 peptides, is analyzed to understand its effect on the chiral enhancement and formation of helical conformation. Furthermore, supramolecular helical polymers mediated by peptides showing stimuli-responsiveness to light, temperature, pH, metal ions and enzymes are emphasized. The stimuli-responsive properties may exert influence on helical conformation and chiral enhancement, and make the conformation tunable. At the same time, the stimuli-responsiveness may afford these supramolecular polymers new functionalities and pose new light on promising applications. The present review hopes to provide readers an updated point view on how peptides mediate the formation of helical supramolecular polymers with environmental responsiveness.

Contents
1 Introduction
2 Amphiphilic peptide-mediated supramolecular helical polymers
2.1 Pure peptides
2.2 Hydrophobic alkyl chain modified peptides
2.3 Aromatic short peptides
2.4 Bolaamphiphilic peptides
2.5 Peptides based on π-π interaction
2.6 Amyloid-like peptides
3 Topological peptide-mediated supramolecular helical polymers
3.1 Cyclopeptides
3.2 Dendritic peptides
3.3 C3 peptides
4 Peptide-based stimuli-responsive supramolecular helical polymers
4.1 Temperature
4.2 Light
4.3 pH
4.4 Metal ions
4.5 Enzyme
5 Conclusion

Key words: peptides, supramolecular polymers, helical polymers, supramolecular assembly, stimuli-responsiveness

CLC Number: 

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