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Progress in Chemistry 2015, Vol. 27 Issue (9): 1240-1250 DOI: 10.7536/PC150132 Previous Articles   Next Articles

• Review and comments •

Application of Novel Nano Fluorescent Probes for Bacteria Detection on the Microchip

Jiang Yan1,3, Xu Yi1,2,3*, Wang Renjie1,3, Su Xi1,3, Dong Chunyan1   

  1. 1. Chemistry and Chemical Engineering College, Chongqing University, Chongqing 400030, China;
    2. Defense Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing 400030, China;
    3. International R&D Center of Micro-Nano Systems and New Materials Technology, Chongqing University, Chongqing 400030, China
  • Received: Revised: Online: Published:
  • Supported by:
    supported by the National Natural Science Foundation of China (No.21375156), the National High Technology Research and Development Program of China (No.2015AA021104), the Research Project of New Detection Technology for Toxic Substances and Illegal Additive in Food, Drug (CSTC, 2012gg B1001), and the Fundamental Research Funds for the Central Universities(No.106112015CDJZR225512).
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Microfluidic system integrated with different functional units is widely employed in biochemical analysis and shows great potentials compared with conventional approaches for bacteria detection. Recently, novel nano fluorescent probes with improved fluorescent properties, low background and enhanced selectivity provide an efficient way for pathogenic bacteria quantitation, especially when they are combined with miniaturized platform or microfluidic device. Several novel nano fluorescent probes for bacteria detection are introduced and discussed in this review. Moreover, special attention has been paid to the recent research about combination of these approaches in bacteria analysis using variety of nano fluorescent probes on the microfluidic chip. It is also focused that the development of effective bacteria detection under the micro scale space with fluorescent monitoring mode.

Contents
1 Introduction
2 The technology of bacteria detection on microfluidic chips
3 New nano-fluorescent probes for bacteria labeled and detection
4 Detection of bacteria by nano-fluorescent probes on microfluidic chip
4.1 Detection of bacteria with nano-fluorescent probes
4.2 Detection of bacteria with nano-fluorescent probes and aptamers
4.3 Detection of bacteria with nano-fluorescent probes and immunoassay
5 Conclusion and perspective

Key words: nano fluorescent probes, microfluidic chip, bacteria detection

CLC Number: 

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