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Progress in Chemistry 2015, Vol. 27 Issue (5): 594-600 DOI: 10.7536/PC141133 Previous Articles   Next Articles

• Review and evaluation •

Molecular Mechanism of Protein S-Nitrosylation and Its Correlation with Human Diseases

Shi Ting1, Chen Ming1, Chen Xiongping1, Wang Jitao1, Wan Ajun2, Zhao Yi-Lei*1   

  1. 1. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;
    2. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Basic Research Program of China (No. 2012CB721005, 2013CB966802), the National Natural Science Foundation of China (No. 21102090, J1210047), and the Shanghai Municipal Council of Science and Technology (No. 13YZ032).
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Protein S-nitrosylation (SNO) is a dynamic and reversible oxidative post-translational modification, widespread in mammals, plants and microorganisms. Previous mechanistic investigation with high-level quantum calculations indicated that many meta-stable intermediates present in the reaction pathway. On the other hand, S-nitrosylation level significantly changes in various human diseases, including tumor, inflammation, aging, Alzheimers disease (AD) and Parkinsons disease (PD). More intensive study has become an urgent need for drug and therapy development. In this paper, molecular mechanism and site-specificity of SNO are summarized, the biological functions are discussed, and especially the correlation between SNO and human diseases are presented.

Contents
1 Formation mechanism of S-nitrosylation (SNO)
2 Site specificity of SNO
3 Detection methods of SNO
4 Biological functions of SNO
5 SNO and diseases
5.1 SNO and transportation of blood
5.2 SNO and diabetes
5.3 SNO and neurodegenerative diseases
5.4 SNO and asthma symptoms
5.5 SNO and cancers
6 SNO and cell apoptosis
7 Conclusion

Key words: nitric oxide, S-nitrosylation, post-translational modification, redox

CLC Number: 

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