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Progress in Chemistry 2015, Vol. 27 Issue (5): 601-613 DOI: 10.7536/PC141042 Previous Articles   Next Articles

• Review and evaluation •

Applications of Superparamagnetic Fe3O4 Nanoparticles in Magnetic Resonance Imaging

Liu Tianhui, Chang Gang, Cao Ruijun, Meng Lingjie*   

  1. Department of Chemistry, School of Science, Xi'an Jiaotong University, Xi'an 710049, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No.21174087, 21474079), the Program for New Century Excellent Talents in University (No.NCET-13-0453),the Postdoctoral Fund of China (No.2013M540738, 2014T70909), and the Fundamental Funds for the Central Universities (No.08142027, 08143101).
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Fe3O4 nanomaterials have attracted tremendous attention in the field of magnetic resonance imaging (MRI) because of their low cost, good biocompatibility, favorable superparamagnetic properties. This article focuses on the controlled preparation methods of superparamagnetic Fe3O4 nanoparticles, and provides an in-depth discussion of the key factors and their influence rules for particle size, crystallinity and magnetic properties. The current status of available methodologies and mechanisms for the assembly and surface modification of Fe3O4 nanoparticles are highlighted to generate high performance and multifunction. We also systematically summarize the effect of particle size, morphology and surface properties on the magnetic and toxic properties of Fe3O4 nanoparticles. Finally, the future opportunities and challenges of Fe3O4 nanomaterials used as MRI contrast agents are addressed to our understanding.

Contents
1 Introduction
2 Controllable preparation of Fe3O4 nanoparticles
2.1 Thermal decomposition
2.2 Coprecipitation
2.3 Solvothermal
2.4 Sol-gel
2.5 Microemulsion
2.6 Sonochemical
3 Assembly of Fe3O4 nanoparticles
3.1 Zero-dimensional sphere
3.2 One-dimensional nanochain
3.3 Multidimensional assembly
4 Surface functionalization of Fe3O4 nanoparticles
4.1 Modified by SiO2
4.2 Modified by polymer
4.3 Multifunctional modification
5 Toxicity
6 MRI applications
6.1 Cell imaging
6.2 Tissue/organ imaging
7 Conclusion

Key words: Fe3O4, nanomaterials, superparamagnetic, surface modification, magnetic resonance imaging (MRI)

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