中文
Earlier issues
Announcement
More
Progress in Chemistry 2015, Vol. 27 Issue (2/3): 275-285 DOI: 10.7536/PC141007 Previous Articles   Next Articles

• Review •

Multifunctional Nanoparticle-Based Adjuvants Used in Cancer Vaccines

Zhang Qian, Zhu Yanhong*, Xu Huibi, Yang Xiangliang   

  1. National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
  • Received: Revised: Online: Published:
  • Supported by:

    The work was supported by the National Basic Research Program of China (No. 2012CB932500).

PDF ( 2673 ) Cited
Export

EndNote

Ris

BibTeX

In recent years immunotherapy has been developed as a promising oncotherapy strategy after surgery, chemotherapy and radiotherapy. Immunotherapy has been widely used in the treatment of cancer including a variety of approaches. It is interesting that the overall efficiency of therapeutic cancer vaccines can be greatly improved when nanoparticle-based adjuvants are used. Significant efforts have been made to synthesize diverse nanoparticles which can fundamentally achieve surface modification and functionalization. In this review, we introduce the role of multifunctional nanoparticle-based adjuvants used in cancer vaccines, particularly focusing on synthesis methods of different types of nanoparticles and therapeutic effects of vaccines. In addition, some new ideas about nanotechnology used in cancer immunotherapy are summarized. Finally, the preliminary analysis and perspective on applying nanotechnology to overcoming the challenges of cancer vaccines are presented.

Contents
1 Introduction
2 Multifunctional nanoparticle-based adjuvants in cancer vaccines
2.1 Protection and controlled release of antigens
2.2 Co-delivery of antigens and immunopotentiators to the same APC
2.3 Immunostimulatory characteristic
2.4 Targeting draining lymph nodes
2.5 Formation of cross-presentation
3 New ideas on nanotechnology used in cancer vaccines
3.1 Self-assembled DNA nanostructures
3.2 Nanoscale artificial antigen presenting cells
3.3 Cancer cell membrane-coated nanoparticles
3.4 Multifunctional nanorods
3.5 Multifunctional Fe3O4-CdSe/ZnS nanoclusters
3.6 Chitosan-coated hollow copper sulfide nanoparticles
4 The influence of administration route on immune response
5 The dilemma of cancer vaccines
6 Outlook

Key words: immunotherapy, cancer vaccine, nanoparticle-based adjuvants, cross-presentation

CLC Number: 

[1] Couzin-Frankel J. Science, 2013, 342: 1432.
[2] McNutt M. Science, 2013, 342: 1417.
[3] Qasim W, Thrasher A J. British Journal of Haematology, 2014, 166: 818.
[4] Kong Y C, Flynn J C. Frontiers in Immunology, 2014, 5: 206.
[5] Platsoucas C D, Jung W J, Heckel M, Pappas J, Fincke J. Anticancer Res., 2004, 24: 3601.
[6] Saleh F. Curr. Pharm. Design, 2005, 11: 3459.
[7] Gottschalk S, Yu F, Ji M J, Kakarla S, Song X T. PloS One, 2013, 8.
[8] Gao J, Bernatchez C, Sharma P, Radvanyi L G, Hwu P. Trends in Immunology, 2013, 34: 90.
[9] Kalinski P, Urban J, Narang R, Berk E, Wieckowski E, Muthuswamy R. Future Oncol., 2009, 5: 379.
[10] Melero I, Gaudemack G, Gerritsen W, Huber C, Parmiani G, Scholl S, Thatcher N, Wagstaff J, Zielinski C, Faulkner I, Mellstedt H. Nat. Rev. Clin. Oncol., 2014, 11: 509.
[11] Guo C Q, Manjili M H, Subjeck J R, Sarkar D, Fisher P B, Wang X Y. Advances in Cancer Research, 2013, 119: 421.
[12] Schlom J, Hodge J W, Palena C, Tsang K Y, Jochems C, Greiner J W, Farsaci B, Madan R A, Heery C R, Gulley J L. Adv. Cancer Res., 2014, 121: 67.
[13] Li W A, Mooney D J. Current Opinion in Immunology, 2013, 25: 238.
[14] Silva J M, Videira M, Gaspar R, Preat V, Florindo H F. Journal Controlled Release, 2013, 168: 179.
[15] Scheinberg D A, McDevitt M R, Dao T, Mulvey J J, Feinberg E, Alidori S. Advanced Drug Delivery Reviews, 2013, 65: 2016.
[16] Zhang W, Wang L, Liu Y, Chen X, Liu Q, Jia J, Yang T, Qiu S, Ma G. Biomaterials, 2014, 35: 6086.
[17] Heo M B, Lim Y T. Biomaterials, 2014, 35: 590.
[18] Smith D M, Simon J K, Baker J R Jr. Nature Reviews Immunology, 2013, 13: 592.
[19] Xu Z, Wang Y, Zhang L, Huang L. ACS Nano, 2014, 8: 3636.
[20] Ballester M, Nembrini C, Dhar N, de Titta A, de Piano C, Pasquier M, Simeoni E, van der Vlies A J, McKinney J D, Hubbell J A, Swartz M A. Vaccine, 2011, 29: 6959.
[21] Heo M B, Cho M Y, Lim Y T. Acta Biomaterialia, 2014, 10: 2169.
[22] Kwong B, Liu H, Irvine D J. Biomaterials, 2011, 32: 5134.
[23] Jia F, Liu X, Li L, Mallapragada S, Narasimhan B, Wang Q. Journal of Controlled Release, 2013, 172: 1020.
[24] Pashine A, Valiante N M, Ulmer J B. Nature Medicine, 2005, 11: S63.
[25] Singh M, O'Hagan D. Nat. Biotechnol., 1999, 17: 1075.
[26] Bachmann M F, Jennings G T. Nature Reviews Immunology, 2010, 10: 787.
[27] Oyewumi M O, Kumar A, Cui Z R. Expert. Rev. Vaccines, 2010, 9: 1095.
[28] Rosenthal J A, Chen L, Baker J L, Putnam D, DeLisa M P. Current Opinion in Biotechnology, 2014, 28: 51.
[29] Palucka K, Banchereau J. Nature Reviews Cancer, 2012, 12: 265.
[30] Scheerlinck J P, Greenwood D L. Drug Discovery Today, 2008, 13: 882.
[31] Xiang S D, Scholzen A, Minigo G, David C, Apostolopoulos V, Mottram P L, Plebanski M. Methods, 2006, 40: 1.
[32] Foged C, Brodin B, Frokjaer S, Sundblad A. International Journal of Pharmaceutics, 2005, 298: 315.
[33] Yue Z G, Wei W, Lv P P, Yue H, Wang L Y, Su Z G, Ma G H. Biomacromolecules, 2011, 12: 2440.
[34] Zhu M T, Nie G J, Meng H, Xia T, Nel A, Zhao Y L. Acc. Chem. Res., 2013, 46: 622.
[35] Schlosser E, Mueller M, Fischer S, Basta S, Busch D H, Gander B, Groettrup M. Vaccine, 2008, 26: 1626.
[36] De Temmerman M L, Rejman J, Demeester J, Irvine D J, Gander B, De Smedt S C. Drug Discovery Today, 2011, 16: 569.
[37] Huang M H, Huang C Y, Lin S C, Chen J H, Ku C C, Chou A H, Liu S J, Chen H W, Chong P, Leng C H. Microbes and Infection/Institut Pasteur, 2009, 11: 654.
[38] Huang M H, Huang C Y, Lien S P, Siao S Y, Chou A H, Chen H W, Liu S J, Leng C H, Chong P. Pharmaceutical Research, 2009, 26: 1856.
[39] Huang M H, Chou A H, Lien S P, Chen H W, Huang C Y, Chen W W, Chong P, Liu S J, Leng C H. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 2009, 90: 832.
[40] Song Y C, Cheng H Y, Leng C H, Chiang S K, Lin C W, Chong P, Huang M H, Liu S J. Journal of Controlled Release, 2014, 173: 158.
[41] Klinman D M. Nature Reviews Immunology, 2004, 4: 249.
[42] Lonsdorf A S, Kuekrek H, Stern B V, Boehm B O, Lehmann P V, Tary-Lehmann M. Journal of Immunology, 2003, 171: 3941.
[43] Heit A, Schmitz F, Haas T, Busch D H, Wagner H. Eur. J. Immunol., 2007, 37: 2063.
[44] Wilson J T, Keller S, Manganiello M J, Cheng C, Lee C C, Opara C, Convertine A, Stayton P S. ACS Nano, 2013, 7: 3912.
[45] Convertine A J, Benoit D S, Duvall C L, Hoffman A S, Stayton P S. Journal of Controlled Release, 2009, 133: 221.
[46] Keller S, Wilson J T, Patilea G I, Kern H B, Convertine A J, Stayton P S. Journal of Controlled Release, 2014.
[47] Standley S M, Mende I, Goh S L, Kwon Y J, Beaudette T T, Engleman E G, Frechet J M J. Bioconjugate Chem., 2007, 18: 77.
[48] Fischer N O, Rasley A, Corzett M, Hwang M H, Hoeprich P D, Blanchette C D. Journal of the American Chemical Society, 2013, 135: 2044.
[49] Broos S, Lundberg K, Akagi T, Kadowaki K, Akashi M, Greiff L, Borrebaeck C A, Lindstedt M. Vaccine, 2010, 28: 5075.
[50] Uto T, Akagi T, Yoshinaga K, Toyama M, Akashi M, Baba M. Biomaterials, 2011, 32: 5206.
[51] Steinman R M. Immunity, 2008, 29: 319.
[52] St John A L, Chan C Y, Staats H F, Leong K W, Abraham S N. Nature Materials, 2012, 11: 250.
[53] Perez-Diez A, Joncker N T, Choi K, Chan W F N, Anderson C C, Lantz O, Matzinger P. Blood, 2007, 109: 5346.
[54] Gilboa E. Nature Reviews Cancer, 2004, 4: 401.
[55] Delamarre L, Pack M, Chang H, Mellman I, Trombetta E S. Science, 2005, 307: 1630.
[56] Bhardwaj N. Trends in Molecular Medicine, 2001, 7: 388.
[57] Amigorena S, Savina A. Current Opinion in Immunology, 2010, 22: 109.
[58] Yoshizaki Y, Yuba E, Sakaguchi N, Koiwai K, Harada A, Kono K. Biomaterials, 2014, 35: 8186.
[59] Yuba E, Harada A, Sakanishi Y, Watarai S, Kono K. Biomaterials, 2013, 34: 3042.
[60] Yuba E, Kono Y, Harada A, Yokoyama S, Arai M, Kubo K, Kono K. Biomaterials, 2013, 34: 5711.
[61] Yuba E, Tajima N, Yoshizaki Y, Harada A, Hayashi H, Kono K. Biomaterials, 2014, 35: 3091.
[62] Sakaguchi N, Kojima C, Harada A, Kono K. Bioconjugate Chem., 2008, 19: 1040.
[63] Murthy N, Robichaud J R, Tirrell D A, Stayton P S, Hoffman A S. Journal of Controlled Release, 1999, 61: 137.
[64] Meyer O, Papahadjopoulos D, Leroux J C. FEBS Lett, 1998, 421: 61.
[65] Yuba E, Harada A, Sakanishi Y, Kono K. Journal of Controlled Release, 2011, 149: 72.
[66] Hirosue S, Kourtis I C, van der Vlies A J, Hubbell J A, Swartz M A. Vaccine, 2010, 28: 7897.
[67] Molino N M, Anderson A K L, Nelson E L, Wang S W. ACS Nano, 2013, 7: 9743.
[68] Ren D, Dalmau M, Randall A, Shindel M M, Baldi P, Wang S W. Advanced Functional Materials, 2012, 22: 3170.
[69] Dalmau M, Lim S R, Wang S W. Nano Letters, 2009, 9: 160.
[70] Dalmau M, Lim S, Wang S W. Biomacromolecules, 2009, 10: 3199.
[71] Park K. Journal of Controlled Release, 2011, 151: 219.
[72] Shen H, Ackerman A L, Cody V, Giodini A, Hinson E R, Cresswell P, Edelson R L, Saltzman W M, Hanlon D J. Immunology, 2006, 117: 78.
[73] Han R, Zhu J, Yang X, Xu H. Journal of Biomedical Materials Research. Part A, 2011, 96: 142.
[74] Panyam J, Zhou W Z, Prabha S, Sahoo S K, Labhasetwar V. FASEB J., 2002, 16.
[75] Davda J, Labhasetwar V. International Journal of Pharmaceutics, 2002, 233: 51.
[76] Hamdy S, Haddadi A, Hung R W, Lavasanifar A. Advanced Drug Delivery Reviews, 2011, 63: 943.
[77] Pack D W, Hoffman A S, Pun S, Stayton P S. Nat. Rev. Drug Discov., 2005, 4: 581.
[78] Boussif O, Lezoualc'h F, Zanta M A, Mergny M D, Scherman D, Demeneix B, Behr J P. Proceedings of the National Academy of Sciences of the United States of America, 1995, 92: 7297.
[79] Hu Y, Litwin T, Nagaraja A R, Kwong B, Katz J, Watson N, Irvine D J. Nano Letters, 2007, 7: 3056.
[80] Li Y, Wang L X, Yang G, Hao F, Urba W J, Hu H M. Cancer Research, 2008, 68: 6889.
[81] Peynshaert K, Manshian B B, Joris F, Braeckmans K, De Smedt S C, Demeester J, Soenen S J. Chemical Reviews, 2014, 114: 7581.
[82] Li H, Li Y, Jiao J, Hu H M. Nature Nanotechnology, 2011, 6: 645.
[83] Nakamura T, Ono K, Suzuki Y, Moriguchi R, Kogure K, Harashima H. Molecular Pharmaceutics, 2014, 11: 2787.
[84] Zhou S, Hashida Y, Kawakami S, Mihara J, Umeyama T, Imahori H, Murakami T, Yamashita F, Hashida M. International Journal of Pharmaceutics, 2014, 471: 214.
[85] Fadel T R, Li N, Shah S, Look M, Pfefferle L D, Haller G L, Justesen S, Wilson C J, Fahmy T M. Small, 2013, 9: 666.
[86] Fadel T R, Fahmy T M. Trends in Biotechnology, 2014, 32: 198.
[87] Faria P C, Santos L I, Coelho J P, Ribeiro H B, Pimenta M A, Ladeira L O, Gomes D A, Furtado C A, Gazzinelli R T. Nano Letters, 2014.
[88] Lee I H, Kwon H K, An S, Kim D, Kim S, Yu M K, Lee J H, Lee T S, Im S H, Jon S. Angewandte Chemie, 2012, 51: 8800.
[89] Shahbazi M A, Almeida P V, Makila E M, Kaasalainen M H, Salonen J J, Hirvonen J T, Santos H A. Biomaterials, 2014, 35: 7488.
[90] Saljoughian N, Zahedifard F, Doroud D, Doustdari F, Vasei M, Papadopoulou B, Rafati S. Parasite Immunology, 2013, 35: 397.
[91] Chen X, Liu Y, Wang L, Liu Y, Zhang W, Fan B, Ma X, Yuan Q, Ma G, Su Z. Molecular Pharmaceutics, 2014, 11: 1772.
[92] Rothemund P W. Nature, 2006, 440: 297.
[93] Douglas S M, Dietz H, Liedl T, Hogberg B, Graf F, Shih W M. Nature, 2009, 459: 414.
[94] Um S H, Lee J B, Park N, Kwon S Y, Umbach C C, Luo D. Nature Materials, 2006, 5: 797.
[95] Li Y, Tseng Y D, Kwon S Y, D'Espaux L, Bunch J S, McEuen P L, Luo D. Nature Materials, 2004, 3: 38.
[96] He Y, Ye T, Su M, Zhang C, Ribbe A E, Jiang W, Mao C. Nature, 2008, 452: 198.
[97] Mohri K, Nishikawa M, Takahashi N, Shiomi T, Matsuoka N, Ogawa K, Endo M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y. ACS Nano, 2012, 6: 5931.
[98] Li J, Pei H, Zhu B, Liang L, Wei M, He Y, Chen N, Li D, Huang Q, Fan C H. ACS Nano, 2011, 5: 8783.
[99] Oelke M, Krueger C, Giuntoli R L, Schneck J P. Trends in Molecular Medicine, 2005, 11: 412.
[100] Oelke M, Maus M V, Didiano D, June C H, Mackensen A, Schneck J P. Nature Medicine, 2003, 9: 619.
[101] Perica K, Tu A, Richter A, Bieler J G, Edidin M, Schneck J P. ACS Nano, 2014, 8: 2252.
[102] Perica K, De Leon Medero A, Durai M, Chiu Y L, Bieler J G, Sibener L, Niemoller M, Assenmacher M, Richter A, Edidin M, Oelke M, Schneck J. Nanomedicine: Nanotechnology, Biology, and Medicine, 2014, 10: 119.
[103] Eggermont L J, Paulis L E, Tel J, Figdor C G. Trends in Biotechnology, 2014, 32: 456.
[104] Fang R H, Hu C M, Luk B T, Gao W, Copp J A, Tai Y, O'Connor D E, Zhang L. Nano Letters, 2014, 14: 2181.
[105] Son Y J, Kim H, Leong K W, Yoo H S. ACS Nano, 2013, 7: 9771.
[106] Jeong J, Kwon E K, Cheong T C, Park H, Cho N H, Kim W. ACS Applied Materials & Interfaces, 2014, 6: 5297.
[107] Cheng C, Wen Y, Xu X, Gu H. Journal of Materials Chemistry, 2009, 19: 8782.
[108] Ge J, Hu Y, Biasini M, Beyermann W P, Yin Y. Angewandte Chemie, 2007, 46: 4342.
[109] Guo L R, Yan D D, Yang D F, Li Y J, Wang X D, Zalewski O, Yan B F, Lu W. ACS Nano, 2014, 8: 5670.
[110] Lobaina Y, Trujillo H, Garcia D, Gambe A, Chacon Y, Blanco A, Aguilar J C. Viral Immunology, 2010, 23: 521.
[111] Hazebrouck S, Przybylski-Nicaise L, Ah-Leung S, Adel-Patient K, Corthier G, Langella P, Wal J M. Vaccine, 2009, 27: 5800.
[112] Mohanan D, Slutter B, Henriksen-Lacey M, Jiskoot W, Bouwstra J A, Perrie Y, Kundig T M, Gander B, Johansen P. Journal of Controlled Release, 2010, 147: 342.
[113] Fong L, Brockstedt D, Benike C, Wu L, Engleman E G. Journal of Immunology, 2001, 166: 4254.
[114] Vasievich E A, Huang L. Molecular Pharmaceutics, 2011, 8: 635.
[115] Alderton G K, Bordon Y. Nature Reviews Immunology, 2012, 12: 237.
[116] Matera L. Cancer Treatment Reviews, 2010, 36: 131.
[117] Pawelec G. Cancer Immunol. Immun., 2006, 55: 61.
[118] Tabi Z, Man S. Advanced Drug Delivery Reviews, 2006, 58: 902.
[119] Blankenstein T, Coulie P G, Gilboa E, Jaffee E M. Nature Reviews Cancer, 2012, 12: 307.
[120] Finn O J. Nature Reviews Immunology, 2003, 3: 630.
[121] Peek L J, Middaugh C R, Berkland C. Advanced Drug Delivery Reviews, 2008, 60: 915.
[1] Qixiao Guan, Heze Guo, Hongjing Dou. Nanocarriers Modified by Cell Membrane and Their Applications in Tumor Immunotherapy [J]. Progress in Chemistry, 2021, 33(10): 1823-1840.
[2] Yuewen Sun, Suxing Jin, Xiaoyong Wang, Zijian Guo. Application Prospect of Metal Complexes in Chemoimmunotherapy of Tumors [J]. Progress in Chemistry, 2018, 30(10): 1573-1583.
[3] Xubo Yuan, Jin Zhao, Lixia Long, Xin Hou, Xubo Yuan*. Biological Carrier for Tumor Immunotherapy [J]. Progress in Chemistry, 2017, 29(10): 1195-1205.
[4] Chen Jibing, Yuan Yuanying, Xu Kecheng. Research Progress of Anti-Cancer Vaccine [J]. Progress in Chemistry, 2013, 25(09): 1588-1593.
[5] Huang Lei,Zhao Fuqun,Huang Xin,Zhang Fushi**. Study of Photoimmunoconjugates [J]. Progress in Chemistry, 2007, 19(04): 527-534.