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Progress in Chemistry 2015, Vol. 27 Issue (1): 91-102 DOI: 10.7536/PC140738 Previous Articles   Next Articles

• Review •

Surface-Enhanced Raman Scattering Tags Used in Cell Recognition, Imaging, Diagnosis and Treatment

Song Chunyuan*, Chen Wenqiang, Yang Yanjun, Yang Boyue, Su Shao, Wang Lianhui*   

  1. Key Lab for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM), and Synergetic Innovation Center for Organic Electronics and Information Displays, Nanjing University of Posts & Telecommunications, Nanjing 210023, China
  • Received: Revised: Online: Published:
  • Supported by:

    The work was surpported by the National Basic Research Program of China (973 Program) (No. 2012CB933301), the National Natural Science Foundation of China (No. 61302027, 21305070, 21475064), the Natural Science Foundation of Jiangsu Province (No. BK20130871), the Program for Changjiang Scholars and Innovative Research Team in University (IRT1148), the Open Research Fund of State Key Laboratory of Bioelectronics (2013G2), Sci-tech Support Plan of Jiangsu Province (No. BE2014719), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and Foundation of Nanjing University of Posts and Telecommunications (NY212032).

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Surface-enhanced Raman scattering (SERS) refers to an abnormal surface optical phenomenon that Raman spectra of the analyte adsorbed on metal nanostructures can be significantly enhanced under laser irradiation. In recent years, SERS has been widely used in the substance detection and biological sensing, which has achieved significant development and shown great potential applications in the biomedical field. In this paper, the preparation principle and the latest development of SERS tags used in cell detection are introduced, and their recent applications in cell recognition, imaging, diagnosis and treatment are reviewed, as well as the detection strategies and issues related to SERS tag-based cell detection are discussed.

Contents
1 Introduction
2 SERS tags
2.1 Noble metal nanoparticles
2.2 Raman reporter molecules
2.3 Surface coating for protection
2.4 Biofunction with biomolecules
3 Application of SERS tags in cell
3.1 Cell recognition
3.2 Cell imaging
3.3 Cell pH sensing
3.4 Cancer diagnosis and treatment
4 Conclusions and outlooks

Key words: surface-enhanced Raman scattering, SERS tag, cell recognition, imaging, diagnosis and treatment

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