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Progress in Chemistry 2014, Vol. 26 Issue (12): 2019-2026 DOI: 10.7536/PC140722 Previous Articles   

• Review •

Properties and Applications of Janus Nanomaterials

Du Juan1, Lu Ying*1, Wang Yilong2, Guo Guiping3, Pan Yingjie1   

  1. 1. Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation, Ministry of Agriculture, Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;
    2. Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai 200092, China;
    3. Nantong Entry-Exit Inspection and Quarantine Bureau, Nantong 226000, China
  • Received: Revised: Online: Published:
  • Supported by:

    The work was supported by the Key Project of Shanghai Agriculture Prosperity through Science and Technology (No. 2009-6-1), the Jiangsu Entry-Exit Inspection and Quarantine Bureau (No. 2013kj34), the Project of Science and Technology Commission of Shanghai Municipality (No. 11DZ2280300) and the Shanghai first-class discipline construction project (Food Science & Engineering)

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Asymmetric nanomaterials (Janus nanomaterials) comprising at least two components of different chemistry, functionality, and/or polarity have attracted great scientific interest in a wide range of applications. Additional properties are attributed to the asymmetric spatial distribution of functionalities on a single anisotropic nanoparticle, like amphiphilicity or new catalytic characteristic. In addition, Janus nanomaterials' synergistic potential for multilevel targeting, and combination therapies make them particularly attractive for biomedical applications including biosensing, targeting delivery and bio-detection. In this paper, the advances in properties and applications of Janus nanomaterials are summarized. First, some properties and applications of Janus nanomaterials are described in three different aspects: amphipathicity, catalytic characteristic and biocompatibility. Second, the main biomedical applications are highlighted, which include biosensing, targeting delivery, gene vaccine and antimicrobial. Finally, the further development in preparation of Janus nanomaterials and their applications in food safety are expected.

Contents
1 Introduction
2 Properties of Janus particles
2.1 Amphipathy
2.2 Catalytic characteristic
2.3 Biocompatibility
3 Construction and applications of bioprobes based on Janus particles
3.1 Biological sensing
3.2 Targeting delivery
3.3 Gene vaccine
3.4 Antibacterial agents
4 Outlook

CLC Number: 

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