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Progress in Chemistry 2014, Vol. 26 Issue (08): 1378-1394 DOI: 10.7536/PC140312 Previous Articles   Next Articles

• Review •

Microbial and Chemical Production of Chondroitin Sulfate

Shi Yugang*1,2, Dang Yali3, Liu Yuhua1, Bai Xue1   

  1. 1. Food Safety Key Lab of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China;
    2. Department of Chemistry, University of Toronto, Toronto M5S;
    3. Institute of Health Food, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
  • Received: Revised: Online: Published:
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No. 21106131, 31101344), the Analysis and Measurement Foundation of Zhejiang Province (No. 2013C37043), the Research Foundation of Educational Commission of Zhejiang Province of China (No. Y201016439) and the Scientific Research Fund for the New Talents of Zhejiang Gongshang University (No. 09-57)

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Chondroitin sulfates (ChS) are a complex polysaccharide having important structural and protective functions and play important roles in many biological processes. It has been widely applied in a variety of fields, such as medicine, biotechnology, pharmacy, food, cosmetics and textiles. This mini-review focuses on the recent advances in microbial and chemical synthesis of such molecules. The productive strains, fermentation conditions, convergent strategies, use of new starting materials, and syntheses of all the ChS variant oligosaccharides are discussed. In addition, suggestions for further studies in syntheses of ChS are proposed based on current research.

Contents
1 Introduction
2 Biotechnological production of ChS and ChS-like products
2.1 Enzymatic synthesis of ChS and ChS-like products
2.2 Microbial production of ChS and ChS-like products
3 Chemical synthesis of ChS and ChS-like products
4 Conclusion and outlook

Key words: chondroitin sulfate, chemical synthesis, enzymatic synthesis, sulfo code

CLC Number: 

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