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Progress in Chemistry 2014, Vol. 26 Issue (05): 784-795 DOI: 10.7536/PC131124 Previous Articles   Next Articles

• Review •

Deep Eutectic Solvents to Organic Synthesis

Wang Ailing1, Zheng Xueliang1,2, Zhao Zhuangzhi1,2, Li Changping1, Zheng Xuefang*1,2   

  1. 1. College of Environment and Chemical Engineering, Dalian University, Dalian 116622;
    2. Liaoning Key Laboratory of Bio-Organic Chemistry, Dalian University, Dalian 116622, China
  • Received: Revised: Online: Published:
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No. 21271036) and the Outstanding Young Talent Fund from the Dalian Science and Technology Bureau (No. 2009J22DW038).

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Deep eutectic solvents(DES) is a new type of environmentally green solvents. Compared with conventional organic solvents, DES have more advantages, such as negligible vapor pressure, non-flammability, good chemical and thermal stability, non-toxicity, biodegradability, recyclability and low price among others. As a new type of solvent, DES has an extremely extensive application prospect. The latest research results of DES is reviewed in this paper. DES as a novel solvent and catalyst was applied in the traditional organic synthesis reaction, mainly including Helogenation reaction, Diels-Alder reaction, Knoevenagel reaction, Henry reaction, Perkin reaction, Paal-Knorr reaction, Biginelli reaction. At last, we hope that DES has a good application prospect in the field of organic synthesis.

Contents
1 Introduction
2 DES in the replacement reaction
2.1 Alkylation of nitrogen
2.2 Alkylation of the alcohol
2.3 Friedel-Crafts alkylation reaction
2.4 Halogenation
2.5 Esterification
3 DES in addition reactions
3.1 Diels-Alder reaction
3.2 Henry reaction
3.3 Cycloaddition
4 DES in condensation reaction
4.1 Knoevenagel condensation
4.2 Perkin reaction
5 DES in the cyclization
5.1 Fischer indole synthesis
5.2 Paal-Knorr reaction
5.3 Biginelli reaction
6 DES in the elimination reactions
7 DES in rearrangement reactions
8 DES in reducing reactions
9 Conclusions and outlook

Key words: green chemistry, deep eutectic solvents, organic synthesis, application

CLC Number: 

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