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Progress in Chemistry 2013, Vol. 25 Issue (09): 1501-1516 DOI: 10.7536/PC130716 Previous Articles   Next Articles

Strategies for Identifying Molecular Targets for Cancer Chemoprevention

Ann M. Bode, Zigang Dong*   

  1. The Hormel Institute University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
  • Received: Online: Published:
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Carcinogenesis is a multistage process involving hundreds of genes and gene products that regulate various cellular functions. The prevailing opinion today is that cancer might be prevented with small molecules that target specific or multiple cancer genes, signaling proteins and transcription factors. Some promising small molecule inhibitors include various dietary factors. Many of these factors appear to act on multiple tumor-associated cellular pathways with potent anticancer activity, low toxicity and limited adverse side effects. Combining agents or using individual agents that target multiple pathways is a strategy that is gaining acceptance. Powerful modern technologies are needed to accelerate the process of drug discovery especially to find compounds that can suppress multiple cellular signaling pathways. Combining supercomputer technologies, such as in silico screening, with protein structure determination and experimental laboratory validation assays to identify multiple protein targets of anticancer compounds is an example of technologies needed. This paper highlights two of the signaling pathways known to play an important role in carcinogenesis and describes the computational strategies used to identify small molecule inhibitors of these pathways. Finally, examples of molecules and their protein targets, which have been identified and validated by these combinational strategies for chemoprevention, are presented.

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[1] Bode A M, Dong Z. Nat. Rev. Cancer, 2009, 9: 508—516
[2] Hong W K. Gynecol. Oncol., 2003, 88: S56-S58
[3] Bode A M, Dong Z. Effects of Dietary Effectors on Signal Transduction Pathways Related to Cancer Prevention. In: Bidlack W R, Rodriguez R L, Eds. Nutritional Genomics——The Impact of Dietary Regulation of Gene Function on Human Disease. New York: CRC Press, 2012. 243—268
[4] Bode A M, Dong Z. Herbal Medicine-Biomolecular and Clinical Aspects. 2nd ed. Benzie I F F, Wachtel-Galor S, Eds. New York: CRC Press-Taylor & Francis Group, 2011. 131—156
[5] Bode A M, Dong Z. Cancer Res., 2011, 71: 2809—2814
[6] Bode A M, Dong Z. Dietary Modulation of Cell Signaling Pathways. Surh Y J, Cadenas E, Dong Z, Packer L, Eds. New York: CRC Press-Taylor & Francis Group, 2009. 45—74
[7] Bode A M, Dong Z. Sci. Signal., 2009, 2(59): mr2
[8] Bode A M, Dong Z. Cancer Lett., 2007, 247: 26—39
[9] Bode A M, Dong Z. Molecular Carcinogenesis, 2006, 45: 422-430
[10] Bode A M, Dong Z. Prog. Nucleic Acid Res. Mol. Biol., 2005, 79: 237—297
[11] Bode A M, Dong Z. Herbal and Traditional Medicine: Molecular Aspects of Health. Packer L, Ong C N, Halliwell B, Eds. New York: Marcel Dekker, 2004. 165—177
[12] Bode A M, Dong Z. Mutat. Res., 2004, 555: 33—51
[13] Bode A M, Dong Z. Phytochemicals in Health and Disease. Bao Y, Fenwick R, Eds. New York: Marcel Dekker, Inc., 2004. 257—284
[14] Bode A M, Dong Z. Nutrition, 2004, 20: 89—94
[15] Choi B Y, Choi H S, Ko K, Cho Y Y, Zhu F, Kang B S, Ermakova S P, Ma W Y, Bode A M, Dong Z. Nat. Struct. Mol. Biol., 2005, 12: 699—707
[16] Blume-Jensen P, Hunter T. Nature, 2001, 411: 355—365
[17] Manning G, Whyte D B, Martinez R, Hunter T, Sudarsanam S. Science, 2002, 298: 1912—1934
[18] Venter J C, Adams M D, Myers E W, et al. Science, 2001, 291: 1304—1351
[19] Smyth L A, Collins I. J. Chem. Biol., 2009, 2: 131—151
[20] Lawrence D S, Niu J. Pharmacol. Ther., 1998, 77: 81—114
[21] Johnson L N. Q. Rev. Biophys., 2009, 42: 1—40
[22] Arora A, Scholar E M. J. Pharmacol. Exp. Ther., 2005, 315: 971—979
[23] Weir B, Zhao X, Meyerson M. Cancer Cell, 2004, 6: 433—438
[24] Ciardiello F, Tortora G. The New England Journal of Medicine, 2008, 358: 1160—1174
[25] Baselga J. Eur. J. Cancer, 2001, 37 (Suppl 4): S16—S22
[26] De Luca A, Carotenuto A, Rachiglio A, Gallo M, Maiello M R, Aldinucci D, Pinto A, Normanno N. J. Cell. Physiol., 2008, 214: 559—567
[27] Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A,Arena S, Saletti P, de Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A. J. Clin. Oncol., 2008, 26: 5705—5712
[28] Hynes N E, Lane H A. Nature Reviews Cancer, 2005, 5: 341—354
[29] Jimeno A, Hidalgo M. Biochim. Biophys. Acta, 2006, 1766: 217—229
[30] Mosesson Y, Yarden Y. Semin. Cancer Biol., 2004, 14: 262—270
[31] Bode A M, Dong Z. Molecular Carcinogenesis, 2007, 46: 591—598
[32] Steelman L S, Chappell W H, Abrams S L, Kempf R C, Long J, Laidler P, Mijatovic S, Maksimovic-Ivanic D, Stivala F, Mazzarino M C, Donia M, Fagone P, Malaponte G, Nicoletti F, Libra M, Milella M, Tafuri A, Bonati A, Bäsecke J, Cocco L, Evangelisti C, Martelli A M, Montalto G, Cervello M, McCubrey J A. Aging (Albany NY), 2011, 3: 192—222
[33] Chappell W H, Steelman L S, Long J M, Kempf R C, Abrams S L, Franklin R A, Bäsecke J, Stivala F, Donia M, Fagone P, Malaponte G, Mazzarino M C, Nicoletti F, Libra M, Maksimovic-Ivanic D, Mijatovic S, Montalto G, Cervello M, Laidler P, Milella M, Tafuri A, Bonati A, Evangelisti C, Cocco L, Martelli A M, McCubrey J A. Oncotarget, 2011, 2: 135—164
[34] Angel P, Hattori K, Smeal T, Karin M. Cell, 1988, 55: 875—885
[35] Davis R J. Trends Biochem. Sci., 1994, 19: 470—473
[36] Kallunki T, Su B, Tsigelny I, Sluss H K, Dérijard B, Moore G, Davis R, Karin M. Genes Dev., 1994, 8: 2996—3007
[37] Sánchez I, Hughes R T, Mayer B J, Yee K, Woodgett J R, Avruch J, Kyriakis J M, Zon L I. Nature, 1994, 372: 794—798
[38] Bode A M, Dong Z. Nature Reviews Cancer, 2004, 4: 793—805
[39] Lu H, Huan C. Curr. Cancer Drug Targets, 2007, 7: 343—353
[40] Medyouf H, Ghysdael J. Cell Cycle, 2008, 7: 297—303
[41] Siu Y T, Jin D Y. Febs J., 2007, 274: 3224—3232
[42] Cowley S, Paterson H, Kemp P, Marshall C J. Cell, 1994, 77: 841—852
[43] Huang C, Ma W Y, Li J, Dong Z. Cancer Research, 1999, 59: 3053—3058
[44] Hynes N E, Boulay A. J. Mammary Gland Biol. Neoplasia, 2006, 11: 53—61
[45] Meric-Bernstam F, Gonzalez-Angulo A M. J. Clin. Oncol., 2009, 27: 2278—2287
[46] Yuan R, Kay A, Berg W J, Lebwohl D. J. Hematol. Oncol., 2009, 2: art. no. 45
[47] Chu E C, Tarnawski A S. Med. Sci. Monit., 2004, 10(10): RA235—RA241
[48] Ittmann M M. Oncology Reports, 1998, 5: 1329—1335
[49] Majumder P K, Sellers W R. Oncogene, 2005, 24: 7465—7474
[50] Chen M L, Xu P Z, Peng X D, Chen W S, Guzman G, Yang X, di Cristofano A, Pandolfi P P, Hay N. Genes Dev., 2006, 20: 1569—1574
[51] Lesche R, Groszer M, Gao J, Wang Y, Messing A, Sun H, Liu X, Wu H. Genesis, 2002, 32: 148—149
[52] Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas G V, Li G, Roy-Burman P, Nelson P S, Liu X, Wu H. Cancer Cell, 2003, 4: 209—221
[53] Bernstein F C, Koetzle T F, Williams G J, Meyer E F Jr, Brice M D, Rodgers J R, Kennard O, Shimanouchi T, Tasumi M. J. Mol. Biol., 1977, 112: 535—542
[54] Xiang Z. Curr. Protein Pept. Sci., 2006, 7: 217—227
[55] McWilliam H, Valentin F, Goujon M, Li W, Narayanasamy M, Martin J, Miyar T, Lopez R. Nucleic Acids Res., 2009, 37: W6—W10
[56] McInnes C. Curr. Opin. Chem. Biol., 2007, 11: 494—502
[57] Rester U. Curr. Opin. Drug Discov. Devel., 2008, 11: 559—568
[58] Lyne P D. Drug Discov. Today, 2002, 7: 1047—1055
[59] Irwin J J, Shoichet B K. J. Chem. Inf. Model., 2005, 45: 177—182
[60] Hartshorn M J, Verdonk M L, Chessari G, Brewerton S C, Mooij W T, Mortenson P N, Murray C W. J. Med. Chem., 2007, 50: 726—741
[61] Chen H, Yao K, Nadas J, Bode A M, Malakhova M, Oi N, Li H, Lubet R A, Dong Z. PLoS One, 2012, 7: e38261
[62] Glide,V5.6, Schrödinger Suite: User manual. Schrödinger, LLC, 2011
[63] Cavasotto C N, Abagyan R A. J. Mol. Biol., 2004, 337: 209—225
[64] Cheng K W, Wong C C, Wang M, He Q Y, Chen F. Mass Spectrom. Rev., 2010, 29: 126—155
[65] Rix U, Superti-Furga G. Nat. Chem. Biol., 2009, 5: 616—624
[66] Harriman D J, Deslongchamps G. J. Mol. Model., 2006, 12: 793—797
[67] Li H, Gao Z, Kang L, Zhang H, Yang K, Yu K, Luo X, Zhu W, Chen K, Shen J, Wang X, Jiang H. Nucleic Acids Res., 2006, 34: W219—W224
[68] Dixon S L, Smondyrev A M, Knoll E H, Rao S N, Shaw D E, Friesner R A. J. Comput. Aided Mol. Des., 2006, 20: 647—671
[69] Kang N J, Lee K W, Kim B H, Bode A M, Lee H J, Heo Y S, Boardman L, Limburg P, Lee H J, Dong Z. Carcinogenesis, 2011, 32: 921—928
[70] Wermuth C G, Ganellin C R, Lindberg P, Mitscher L A. Pure and Applied Chemistry, 1998, 70: 1129—1143
[71] Willett P, Barnard J M, Downs G M. J. Chem. Inf. Comput. Sci., 1998, 38: 983—996
[72] Berman H M, Westbrook J, Feng Z, Gilliland G, Bhat T N, Weissig H, Shindyalov I N, Bourne P E. Nucleic Acids Res., 2000, 28: 235—242
[73] Oi N, Jeong C H, Nadas J, Cho Y Y, Pugliese A, Bode A M, Dong Z. Cancer Res., 2010, 70: 9755—9764
[74] Nagarajan S, Doddareddy M, Choo H, Cho Y S, Oh K S, Lee B H, Pae A N. Bioorg. Med. Chem., 2009, 17: 2759—2766
[75] Cho Y Y, Lee M H, Lee C J, Yao K, Lee H S, Bode A M, Dong Z. Carcinogenesis, 2012, 33(12): 2529—2537
[76] Cho Y Y, Yao K, Pugliese A, Malakhova M L, Bode A M, Dong Z. Cancer Res., 2009, 69: 4398—4406
[77] Ermakova S, Choi B Y, Choi H S, Kang B S, Bode A M, Dong Z. J. Biol. Chem., 2005, 280: 16882—16890
[78] Ermakova S P, Kang B S, Choi B Y, Choi H S, Schuster T F, Ma W Y, Bode A M, Dong Z. Cancer Res., 2006, 66: 9260—9269
[79] He Z, Tang F, Ermakova S, Li M, Zhao Q, Cho Y Y, Ma W Y, Choi H S, Bode A M, Yang C S, Dong Z. Molecular Carcinogenesis, 2008, 47: 172—183
[80] Jeong C H, Bode A M, Pugliese A, Cho Y Y, Kim H G, Shim J H, Jeon Y J, Li H, Jiang H, Dong Z. Cancer Res., 2009, 69: 5584—5591
[81] Jung S K, Lee K W, Byun S, Kang N J, Lim S H, Heo Y S, Bode A M, Bowden G T, Lee H J, Dong Z. Cancer Res., 2008, 68: 6021—6029
[82] Jung S K, Lee K W, Byun S, Lee E J, Kim J E, Bode A M, Dong Z, Lee H J. Carcinogenesis, 2010, 31: 911—917
[83] Jung S K, Lee K W, Kim H Y, Oh M H, Byun S, Lim S H, Heo Y S, Kang N J, Bode A M, Dong Z, Lee H J. Biochem. Pharmacol., 2010, 79: 1455—1461
[84] Kang N J, Lee K W, Kwon J Y, Hwang M K, Rogozin E A, Heo Y S, Bode A M, Lee H J, Dong Z. Cancer Prev. Res. (Phila), 2008, 1: 522—531
[85] Kang N J, Lee K W, Lee D E, Rogozin E A, Bode A M, Lee H J, Dong Z. J. Biol. Chem., 2008, 283(30): 20664—20673
[86] Kang N J, Lee K W, Rogozin E A, Cho Y Y, Heo Y S, Bode A M, Lee H J, Dong Z. J. Biol. Chem., 2007, 282: 32856—32866
[87] Kang N J, Lee K W, Shin B J, Jung S K, Hwang M K, Bode A M, Heo Y S, Lee H J, Dong Z. Carcinogenesis, 2009, 30: 321—330
[88] Kim D J, Li Y, Reddy K, Lee M H, Kim M O, Cho Y Y, Lee S Y, Kim J E, Bode A M, Dong Z. Cancer Research, 2012, 72(12): 3060—3068
[89] Kim D J, Reddy K, Kim M O, Li Y, Nadas J, Cho Y Y, Kim J E, Shim J H, Song N R, Carper A, Lubet R A, Bode A M, Dong Z. Cancer Prev. Res. (Phila), 2011, 4: 1842—1851
[90] Kim J E, Lee D E, Lee K W, Son J E, Seo S K, Li J, Jung S K, Heo Y S, Mottamal M, Bode A M, Dong Z, Lee H J. Cancer Prev. Res. (Phila), 2011, 4: 582—591
[91] Kwon J Y, Lee K W, Kim J E, Jung S K, Kang N J, Hwang M K, Heo Y S, Bode A M, Dong Z, Lee H J. Carcinogenesis, 2009, 30: 1932—1940
[92] Lee D E, Lee K W, Byun S, Jung S K, Song N, Lim S H, Heo Y S, Kim J E, Kang N J, Kim B Y, Bowden G T, Bode A M, Lee H J, Dong Z. J. Biol. Chem., 2011, 286: 14246—14256
[93] Lee D E, Lee K W, Jung S K, Lee E J, Hwang J A, Lim T G, Kim B Y, Bode A M, Lee H J, Dong Z. Carcinogenesis, 2011, 32: 629—635
[94] Lee D E, Lee K W, Song N R, Seo S K, Heo Y S, Kang N J, Bode A M, Lee H J, Dong Z. J. Biol. Chem., 2010, 285: 21458—21466
[95] Lee K M, Lee K W, Byun S, Jung S K, Seo S K, Heo Y S, Bode A M, Lee H J, Dong Z. Cancer Prev. Res. (Phila), 2010, 3: 454—465
[96] Lee K M, Lee K W, Jung S K, Lee E J, Heo Y S, Bode A M, Lubet R A, Lee H J, Dong Z. Biochem. Pharmacol., 2010, 80: 2042—2049
[97] Lee K W, Bode A M, Dong Z. Nat. Rev. Cancer, 2011, 11: 211—218
[98] Lee K W, Kang N J, Heo Y S, Rogozin E A, Pugliese A, Hwang M K, Bowden G T, Bode A M, Lee H J, Dong Z. Cancer Res., 2008, 68: 946—955
[99] Lee K W, Kang N J, Rogozin E A, Kim H G, Cho Y Y, Bode A M, Lee H J, Surh Y J, Bowden G T, Dong Z. Carcinogenesis, 2007, 28: 1918—1927
[100] Lee K W, Kang N J, Rogozin E A, Oh S M, Heo Y S, Pugliese A, Bode A M, Lee H J, Dong Z. Int. J. Cancer, 2008, 123: 2487—2496
[101] Lee S B, Cha K H, Selenge D, Solongo A, Nho C W. Biol. Pharm. Bull., 2007, 30: 1074—1079
[102] Li J, Malakhova M, Mottamal M, Reddy K, Kurinov I, Carper A, Langfald A, Oi N, Kim M O, Zhu F, Sosa C P, Zhou K, Bode A M, Dong Z. Cancer Research, 2012, 72: 260—270
[103] Li J, Mottamal M, Li H, Liu K, Zhu F, Cho Y Y, Sosa C P, Zhou K, Bowden G T, Bode A M, Dong Z. Carcinogenesis, 2012, 33: 459—465
[104] Li M, He Z, Ermakova S, Zheng D, Tang F, Cho Y Y, Zhu F, Ma W Y, Sham Y, Rogozin E A, Bode A M, Cao Y, Dong Z. Cancer Epidemiol. Biomarkers Prev., 2007, 16: 598—605
[105] Li X, Li H, Li S, Zhu F, Kim D J, Xie H, Li Y, Nadas J, Oi N, Zykova T A, Yu D H, Lee M H, Kim M O, Wang L, Ma W, Lubet R A, Bode A M, Dong Z, Dong Z. Carcinogenesis, 2012, 33(12): 2548—2557
[106] Li Y, Kim D J, Ma W, Lubet R A, Bode A M, Dong Z. J. Chem. Inf. Model., 2011, 51: 2904—2914
[107] Liu K, Cho Y Y, Yao K, Nadas J, Kim D J, Cho E J, Lee M H, Pugliese A, Zhang J, Bode A M, Dong Z, Dong Z. J. Biol. Chem., 2011, 286: 2057—2066
[108] Liu K, Park C, Li S, Lee K W, Liu H, He L, Soung N K, Ahn J S, Bode A M, Dong Z, Kim B Y, Dong Z. Carcinogenesis, 2012, 33: 1406—1411
[109] Malakhova M, Kurinov I, Liu K, Zheng D, D'Angelo I, Shim J H, Steinman V, Bode A M, Dong Z. PLoS One, 2009, 4: e8044
[110] Malakhova M, Tereshko V, Lee S Y, Yao K, Cho Y Y, Bode A, Dong Z. Nat. Struct. Mol. Biol., 2008, 15: 112—113
[111] Oi N, Chen H, Ok Kim M, Lubet R A, Bode A M, Dong Z. Cancer Prev. Res. (Phila), 2012, 5: 1103—1114
[112] Shim J H, Choi H S, Pugliese A, Lee S Y, Chae J I, Choi B Y, Bode A M, Dong Z. J. Biol. Chem., 2008, 283: 28370—28379
[113] Shim J H, Su Z Y, Chae J I, Kim D J, Zhu F, Ma W Y, Bode A M, Yang C S, Dong Z. Cancer Prev. Res. (Phila), 2010, 3: 670—679
[114] Urusova D V, Shim J H, Kim D J, Jung S K, Zykova T A, Carper A, Bode A M, Dong Z. Cancer Prev. Res. (Phila), 2011, 4:1366—1377
[115] Xie H, Lee M H, Zhu F, Reddy K, Peng C, Li Y, Lim do Y, Kim D J, Li X, Kang S, Li H, Ma W, Lubet R A, Ding J, Bode A M, Dong Z. Cancer Research, 2013, 73(2): 716—724
[116] Xie H, Zhu F, Huang Z, Lee M H, Kim D J, Li X, Lim do Y, Jung S K, Kang S, Li H, Reddy K, Wang L, Ma W, Lubet R A, Bode A M, Dong Z. Carcinogenesis, 2012, 33: 1814—1821
[117] Yao K, Cho Y Y, Bode A M, Vummenthala A, Park J G, Liu K, Pang Y P, Dong Z. FEBS Lett., 2009, 583: 2208—2212
[118] Zykova T A, Zhu F, Zhai X, Ma W Y, Ermakova S P, Lee K W, Bode A M, Dong Z. Molecular Carcinogenesis, 2008, 47: 797—805
[119] Cho Y Y, Bode A M, Mizuno H, Choi B Y, Choi H S, Dong Z. Cancer Res., 2004, 64: 3855—3864
[120] Clark D E, Errington T M, Smith J A, Frierson H F Jr, Weber M J, Lannigan D A. Cancer Res., 2005, 65: 3108—3116
[121] David J P, Mehic D, Bakiri L, Schilling A F, Mandic V, Priemel M, Idarraga M H, Reschke M O, Hoffmann O, Amling M, Wagner E F. J. Clin. Invest., 2005, 115: 664—672
[122] Jones S W, Erikson E, Blenis J, Maller J L, Erikson R L. Proc. Natl. Acad. Sci. U. S. A., 1988, 85: 3377—3381
[123] Davis I W, Leaver-Fay A, Chen V B, Block J N, Kapral G J, Wang X, Murray L W, Arendall W B 3rd, Snoeyink J, Richardson J S, Richardson D C. Nucleic Acids Res., 2007, 35: W375—W383
[124] Ramachandran G N, Ramakrishnan C, Sasisekharan V. J. Mol. Biol., 1963, 7: 95—99
[125] Miean K H, Mohamed S. J. Agric. Food chem., 2001, 49: 3106—3112
[126] Friesner R A, Banks J L, Murphy R B, Halgren T A, Klicic J J, Mainz D T, Repasky M P, Knoll E H, Shelley M, Perry J K, Shaw D E, Francis P, Shenkin P S. Journal of Medicinal Chemistry, 2004, 47:1739—1749
[127] Clavin M, Gorzalczany S, Macho A, Muñoz E, Ferraro G, Acevedo C, Martino V. J. Ethnopharmacol., 2007, 112: 585—589
[128] Aronov A M, Baker C, Bemis G W, Cao J, Chen G, Ford P J, Germann U A, Green J, Hale M R, Jacobs M, Janetka J W, Maltais F, Martinez-Botella G, Namchuk M N, Straub J, Tang Q, Xie X. Journal of Medicinal Chemistry, 2007, 50: 1280—1287
[129] Bode A M, Ma W Y, Surh Y J, Dong Z. Cancer Res., 2001, 61: 850—853
[130] Gao Z, Li H, Zhang H, Liu X, Kang L, Luo X, Zhu W, Chen K, Wang X, Jiang H. BMC Bioinformatics, 2008, 9: 104
[131] Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C, Kouroumalis E, Martin P M, Castanas E. J. Cell Biochem., 2000, 78: 429—441
[132] German J B, Walzem R L. Annu. Rev. Nutr., 2000, 20: 561—593
[133] Kris-Etherton P M, Hecker K D, Bonanome A, Coval S M, Binkoski A E, Hilpert K F, Griel A E, Etherton T D. Am. J. Med., 2002,113(Suppl 9B): 71S—88S
[134] Kalra N, Roy P, Prasad S, Shukla Y. Life Sci., 2008, 82: 348—358
[135] Huang C, Ma W Y, Goranson A, Dong Z. Carcinogenesis, 1999, 20: 237—242
[136] She Q B, Huang C, Zhang Y, Dong Z. Molecular Carcinogenesis, 2002, 33: 244—250
[137] She Q B, Bode A M, Ma W Y, Chen N Y, Dong Z. Cancer Res., 2001, 61: 1604—1610
[138] Surh Y J. Nature Reviews Cancer, 2003, 3: 768—780
[139] Dong Z. Mutation Research, 2003, 523/524: 145—150
[140] Slimestad R, Fossen T, Vagen I M. J. Agric. Food Chem., 2007, 55: 10067—10080
[141] Wallace S N, Carrier D J, Clausen E C. Phytochem. Anal., 2005, 16: 7—16
[142] Rohdewald P. Int. J. Clin. Pharmacol. Ther., 2002, 40: 158—168
[143] Kiehlmann E, Li E P M. J. Nat. Products, 1995, 58: 450—455
[144] Haraguchi H, Mochida Y, Sakai S, Masuda H, Tamura Y, Mizutani K, Tanaka O, Chou W H. Biosci. Biotechnol. Biochem., 1996, 60: 945—948
[145] Kostyuk V A, Kraemer T, Sies H, Schewe T. FEBS Lett., 2003, 537: 146—150
[146] Wang Y H, Wang W Y, Chang C C, Liou K T, Sung Y J, Liao J F, Chen C F, Chang S, Hou Y C, Chou Y C, Shen Y C. J. Biomed. Sci., 2006, 13: 127—141
[147] Brusselmans K, Vrolix R, Verhoeven G, Swinnen J V. J. Biol. Chem., 2005, 280: 5636—5645
[148] Stamos J, Sliwkowski M X, Eigenbrot C. J. Biol. Chem., 2002, 277: 46265—46272
[149] Berndt A, Miller S, Williams O, Le D D, Houseman B T, Pacold J I, Gorrec F, Hon W C, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz M K, Shokat K M, Shaw J P, Williams R L. Nature Chemical Biology, 2010, 6: 117—124
[150] Steele V E. J. Biochem. Mol. Biol., 2003, 36: 78—81
[151] Steele V E, Kelloff G J. Mutation Research, 2005, 591: 16—23
[152] Aggarwal B B, Sethi G, Baladandayuthapani V, Krishnan S, Shishodia S. J. Cell. Biochem., 2007, 102: 580—592
[153] Aggarwal B B, Shishodia S. Biochemical Pharmacology, 2006, 71: 1397—1421

[1] . Metabolism, Toxicity, and Biomonitoring of Arsenic Species [J]. Progress in Chemistry, 2009, 21(0203): 474-482.