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Progress in Chemistry 2014, Vol. 26 Issue (01): 140-151 DOI: 10.7536/PC130648 Previous Articles   Next Articles

• Review •

Separation and Characterization of Block Copolymers by Liquid Chromatography at the Critical Condition

Fu Chao1,2, Zhu Yutian*2, Shi Dean*1   

  1. 1. Faculty of Materials Science and Engineering, Hubei University, Wuhan 430062;
    2. Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun 130022, China
  • Received: Revised: Online: Published:
  • Supported by:

    The work was supported by the National Natural Science Foundation of China for Youth Science Funds (No. 21104083), the National Natural Science Foundation of China for General Program (No. 51173037), the Scientific Development Program of Jilin Province (No. 202101007) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry

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Block copolymer is a special type of copolymer in which two or more segments of polymers (blocks) are joined together by covalent bond. It has received more and more attention because it can combine the excellent properties from different polymers into an excellent functional polymer material. However, it is still a challenging task to separate and characterize the block copolymers. As a new type of chromatographic technique, liquid chromatography at the critical condition (LCCC) can make a block of the block copolymer "chromatographically invisible" at the critical condition of the corresponding homopolymer, so that the retention of the block copolymer is determined solely by the other block that is not under critical condition. In this review, the mechanism and approach of LCCC technique are introduced. The recently studies for LCCC analysis of block copolymer are systemically reviewed. The limitation and future development of LCCC method are also discussed.

Contents
1 Introduction
2 Mechanism of LCCC separation of block copolymers
3 LCCC separation of block copolymers
3.1 Selection of solvent
3.2 Selection of stationary phase
3.3 Adjustment of temperature
4 Applications of LCCC separation of block copolymers
5 Computer simulations for the LCCC analysis of block copolymers
6 Conclusions and future developments

Key words: block copolymers, liquid chromatography at the critical condition, separation and characterization, block length distribution, chemical composition distribution

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[1] Retsos H, Margiolaki I, Messaritaki A, Anastasiadis S H. Macromolecules, 2001, 34: 5295.
[2] Retsos H, Anastasiadis S H, Pispas S, Mays J W, Hadjichristidis N. Macromolecules, 2003, 37: 524.
[3] Luo Y, Wang X, Zhu Y, Li B G, Zhu S. Macromolecules, 2010, 43: 7472.
[4] Attard G S, Glyde J C, Göltner C G. Nature, 1995, 378: 366.
[5] Bajpai A K, Shukla S K, Bhanu S, Kankane S. Prog. Polym. Sci., 2008, 33: 1088.
[6] Savi D? R, Luo L, Eisenberg A, Maysinger D. Science, 2003, 300: 615.
[7] Thurn-Albrecht T, Schotter J, Kästle G, Emley N, Shibauchi T, Krusin-Elbaum L, Guarini K, Black C, Tuominen M, Russell T. Science, 2000, 290: 2126.
[8] Kim S O, Solak H H, Stoykovich M P, Ferrier N J, de Pablo J J, Nealey P F. Nature, 2003, 424: 411.
[9] Park I, Park S, Cho D, Chang T, Kim E, Lee K, Kim Y J. Macromolecules, 2003, 36: 8539.
[10] Tennikov M, Nefedov P, Lazareva M, Frenkel S Y. Vysokomol. Sojed. (Moscow), 1977, A19: 657
[11] Belenky B G, Valchikhina M D, Vakhtina I A, Gankina E S, Tarakanov O G. J. Chromatogr. A, 1976, 129: 115.
[12] Belenky B G, Gankina E S, Tennikov M B, Vilenchik L Z. J. Chromatogr. A, 1978, 147: 99.
[13] Skvortsov A M, Belen'kii B G, Gankina E S, Tennikov M B. Polym. Sci. USSR, 1978, 20: 768.
[14] Skvortsov A M, Gorbunov A A. Polym. Sci. USSR, 1979, 21: 371.
[15] Gorbunov A A, Zhulina E B, Skvortsov A M. Polymer, 1982, 23: 1133.
[16] Gorbunov A A, Skvortsov A M. Adv. Colloid Interface Sci., 1995, 62: 31.
[17] Entelis S, Evreinov V, Gorshkov A. Adv. Polym. Sci., 1986, 76: 129.
[18] Berek D. Macromol. Symp., 1996, 110: 33.
[19] Pasch H, Trathnigg B. HPLC of Polymers. Berlin: Springer Verlag, 1999. 151.
[20] Pasch H. In Polymer Analysis Polymer Physics. Berlin: Springer Berlin Heidelberg, 1997. 1.
[21] Pasch H, Gallot Y, Trathnigg B. Polymer, 1993, 34: 4986.
[22] Pasch H, Brinkmann C, Gallot Y. Polymer, 1993, 34: 4100.
[23] Pasch H, Augenstein M. Makromol. Chem., 1993, 194: 2533.
[24] Pasch H, Brinkmann C, Much H, Just U. J. Chromatogr. A, 1992, 623: 315.
[25] Lee W, Park S, Chang T. Anal. Chem., 2001, 73: 3884.
[26] Orelli S, Jiang W, Wang Y. Macromolecules, 2004, 37: 10073.
[27] Gong Y, Wang Y. Macromolecules, 2002, 35: 7492.
[28] Jiang W, Khan S, Wang Y. Macromolecules, 2005, 38: 7514.
[29] Gorbunov A A, Vakhrushev A V. J. Chromatogr. A, 2010, 1217: 4825.
[30] Falkenhagen J, Weidner S. Anal. Chem., 2009, 81: 282.
[31] Ljubi T S, Pahovnik D, igon M, agar E. Scientific World J., 2012, 1.
[32] Brun Y. J. Liq. Chromatogr. Relat. Technol., 1999, 22: 3027.
[33] Chang T. In Liquid Chromatography/ FTIR Microspectroscopy/ Microwave Assisted Synthesis. Berlin: Springer Berlin Heidelberg, 2003. 1.
[34] Pasch H. Macromol. Symp., 1996, 110: 107.
[35] Svensson B, Olsson U, Alexandridis P. Langmuir, 2000, 16: 6839.
[36] Zimina T M, Kever Y Y, Melenevskaya Y Y, Zgonnik V N, Belen'kii B G. Polym. Sci. USSR, 1991, 33: 1250.
[37] Malik M, Ahmed H, Trathnigg B. Anal. Bioanal. Chem., 2009, 393: 1797.
[38] Im K, Park H W, Kim Y, Ahn S, Chang T, Lee K, Lee H J, Ziebarth J, Wang Y. Macromolecules, 2008, 41: 3375.
[39] Al Samman M, Radke W, Khalyavina A, Lederer A. Macromolecules, 2010, 43: 3215.
[40] Berek D. Mater. Res. Innov., 2001, 4: 365.
[41] Baran K, Laugier S, Cramail H. Int. J. Polym. Anal. Char., 2000, 6: 123.
[42] Inglis A J, Barner-Kowollik C. Polym. Chem., 2011, 2: 126.
[43] Olesik S. Anal. Bioanal. Chem., 2004, 378: 43.
[44] Berek D. Anal. Bioanal. Chem., 2010, 396: 421.
[45] Evreinov V, Gorshkov A, Prudskova T, Gur'yanova V, Pavlov A, Malkin A Y, Entelis S. Polym. Bull., 1985, 14: 131.
[46] Lee H, Lee W, Chang T, Choi S, Lee D, Ji H, Nonidez W K, Mays J W. Macromolecules, 1999, 32: 4143.
[47] Lee H J, Chang T Y, Lee D S, Shim M S, Ji H N, Nonidez W K, Mays J W. Anal. Chem., 2001, 73: 1726.
[48] Gorshkov A, Much H, Becker H, Pasch H, Evreinov V, Entelis S. J. Chromatogr. A, 1990, 523: 91.
[49] Pasch H, Zammert I. J. Liq. Chromatogr. Relat. Technol., 1994, 17: 3091.
[50] Zimina T M, Kever J J, Melenevskaya E Y, Fell A F. J. Chromatogr. A, 1992, 593: 233.
[51] Falkenhagen J, Much H, Stauf W, Müller A H E. Macromolecules, 2000, 33: 3687.
[52] Pasch H, Augenstein M, Trathnigg B. Macromol. Chem. Phys., 1994, 195: 743.
[53] Schmid C, Weidner S, Falkenhagen J, Barner-Kowollik C. Macromolecules, 2012, 45: 87.
[54] 钟亚兰(Zhong Y L), 蒋序林(Jiang X L). 化学进展(Progress in Chemistry), 2010, 22(4): 706.
[55] Baumgaertel A, Altunta?瘙塂 E, Schubert U S. J. Chromatogr. A, 2012, 1240: 1.
[56] van Hulst M, van der Horst A, Kok W T, Schoenmakers P J. J. Sep. Sci., 2010, 33: 1414.
[57] Macko T, Hunkeler D, Berek D. Macromolecules, 2002, 35: 1797.
[58] Girod M, Phan T N T, Charles L. Rapid Commun. Mass Spectrom, 2008, 22: 3767.
[59] Girod M, Phan T N T, Charles L. Rapid Commun. Mass. Sp, 2009, 23: 1476.
[60] Girod M, Beaudoin E, Charles L. Anal. Methods, 2009, 1: 128.
[61] Nefedov P, Zhmakina T. Polym. Sci. USSR, 1981, 23: 304.
[62] Baran K, Laugier S, Cramail H. Macromol. Chem. Phys., 1999, 200: 2074.
[63] Braun D, Esser E, Rasch H. Int. J. Polym. Anal. Ch., 1998, 4: 501.
[64] Berek D. Macromolecules, 1998, 31: 8517.
[65] Skvortsov A, Gorbunov A, Berek D, Trathnigg B. Polymer, 1998, 39: 423.
[66] Yun H, Olesik S V, Marti E H. J. Micro. Sep., 1999, 11: 53.
[67] Phillips S, Olesik S V. Anal. Chem., 2002, 74: 799.
[68] Souvignet I, Olesik S V. Anal. Chem., 1997, 69: 66.
[69] Yun H, Olesik S V, Marti E H. Anal. Chem., 1998, 70: 3298.
[70] Chang T, Lee H C, Lee W, Park S, Ko C. Macromol. Chem. Phys., 1999, 200: 2188.
[71] Kanazawa H, Sunamoto T, Matsushima Y, Kikuchi A, Okano T. Anal. Chem., 2000, 72: 5961.
[72] 赵贝贝(Zhao B B), 张艳(Zhang Y), 唐涛(Tang T), 王风云(Wang F Y), 张维冰(Zhang W B), 李彤(Li T). 化学进展(Progress in Chemistry), 2012, 24(1): 122.
[73] Hiller W, Pasch H, Sinha P, Wagner T, Thiel J, Wagner M, Müellen K. Macromolecules, 2010, 43: 4853.
[74] Abdulahad A I, Ryu C Y. J. Polym. Sci. Part B: Polym. Phys., 2009, 47: 2533.
[75] Hiller W, Sinha P, Pasch H. Macromol. Chem. Phys., 2009, 210: 605.
[76] Falkenhagen J, Much H, Stauf W, Müller A. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem. ), 1999, 40: 984.
[77] Mass V, Bellas V, Pasch H. Macromol. Chem. Phys., 2008, 209: 2026.
[78] Sinha P, Hiller W, Bellas V, Pasch H. J. Sep. Sci., 2012, 35: 1731.
[79] Malik M I, Sinha P, Bayley G M, Mallon P E, Pasch H. Macromol. Chem. Phys., 2011, 212: 1221.
[80] Park S, Ryu D Y, Kim J K, Ree M, Chang T. Polymer, 2008, 49: 2170.
[81] Lee W, Cho D, Chang T, Hanley K J, Lodge T P. Macromolecules, 2001, 34: 2353.
[82] Im K, Park H W, Kim Y, Chung B, Ree M, Chang T. Anal. Chem., 2007, 79: 1067.
[83] Min K, Gao H, Matyjaszewski K. J. Am. Chem. Soc., 2005, 127: 3825.
[84] Hiller W, Sinha P, Pasch H. Macromol. Chem. Phys., 2007, 208: 1965.
[85] Baran K, Laugier S, Cramail H. J. Chromatogr. B, 2001, 753: 139.
[86] Pasch H, Rode K. J. Chromatogr. A, 1995, 699: 21.
[87] Trathnigg B, Gorbunov A. Macromol. Symp., 2006, 237: 18.
[88] Trathnigg B. Polymer, 2005, 46: 9211.
[89] Malik M I, Trathnigg B, Kappe C O. Macromol. Chem. Phys., 2007, 208: 2510.
[90] Malik M I, Trathnigg B, Oliver Kappe C. Eur. Polym. J., 2009, 45: 899.
[91] Malik M I, Trathnigg B, Saf R. J. Chromatogr. A, 2009, 1216: 6627.
[92] Malik M I, Trathnigg B, Bartl K, Saf R. Anal. Chim. Acta, 2010, 658: 217.
[93] Lee W, Cho D, Chun B O, Chang T, Ree M. J. Chromatogr. A, 2001, 910: 51.
[94] Ahmed H, Trathnigg B, Kappe C O, Saf R. Eur. Polym. J., 2009, 45: 2338.
[95] Ahmed H, Trathnigg B, Kappe C O, Saf R. Eur. Polym. J., 2010, 46: 494.
[96] Fandrich N, Falkenhagen J, Weidner S M, Staal B, Thünemann A F, Laschewsky A. Macromol. Chem. Phys., 2010, 211: 1678.
[97] Baumgaertel A, Weber C, Fritz N, Festag G, Altuntas E, Kempe K, Hoogenboom R, Schubert U S. J. Chromatogr. A, 2011, 1218: 8370.
[98] Macko T, Hunkeler D. In Chromatography/FTIR Microspectroscopy/Microwave Assisted Synthesis. Berlin: Springer-Verlag Berlin, 2003. 61.
[99] Zimina T M, Fell A F, Castledine J B. Polymer, 1992, 33: 4129.
[100] Zimina T M, Kever Y Y, Melenevskaya Y Y, Zgonnik V N, Belenkii B G. Vysokomolekulyarnye Soedineniya Seriya A, 1991, 33: 1349.
[101] Jacquin M, Muller P, Lizarraga G, Bauer C, Cottet H, Théodoly O. Macromolecules, 2007, 40: 2672.
[102] Jacquin M, Muller P, Talingting-Pabalan R, Cottet H, Berret J, Futterer T, Théodoly O. J. Colloid Interf. Sci., 2007, 316: 897.
[103] Malik M I, Harding G W, Grabowsky M E, Pasch H. J. Chromatogr. A, 2012, 1244: 77.
[104] Schmid C, Falkenhagen J, Barner-Kowollik C. J. Polym. Sci., Part A: Pdym. Chem., 2011, 49: 1.
[105] Malik M I, Harding G W, Pasch H. Anal. Bioanal. Chem., 2012, 403: 601.
[106] Rollet M, Glé D, Phan T N T, Guillaneuf Y, Bertin D, Gigmes D. Macromolecules, 2012, 45: 7171.
[107] Ahmed H, Trathnigg B. J. Sep. Sci., 2009, 32: 1390.
[108] Malik M I, Trathnigg B, Kappe C O. J. Chromatogr. A, 2009, 1216: 1167.
[109] Malik M I, Trathnigg B. J. Sep. Sci., 2009, 32: 1771.
[110] Macko T, Brüll R, Zhu Y, Wang Y. J. Sep. Sci., 2010, 33: 3446.
[111] Yang X, Zhu Y, Wang Y. Polymer, 2013, 54: 3730.
[112] Ziebarth J D, Williams J, Wang Y. Macromolecules, 2008, 41: 4929.
[113] Patel B, Ziebarth J D, Wang Y. Macromolecules, 2010, 43: 2069.
[114] Ziebarth J D, Wang Y, Polotsky A, Luo M. Macromolecules, 2007, 40: 3498.
[115] Zhu Y, Ziebarth J, Macko T, Wang Y. Macromolecules, 2010, 43: 5888.
[116] Riess G. Prog. Polym. Sci., 2003, 28: 1107.
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