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Progress in Chemistry 2013, Vol. 25 Issue (12): 2119-2130 DOI: 10.7536/PC130542 Previous Articles   Next Articles

Special Issue: 酶化学

• Review •

Applications of DNAzymes in the Detection of Heavy Metal Ions

Li Hui, Kong Deming*   

  1. Research Centre for Analytical Sciences, Department of Chemistry, Nankai University, Tianjin 300071, China
  • Received: Revised: Online: Published:
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DNAzymes, obtained by in vitro screening technique (systematic evolution of ligands by exponential enrichment, SELEX technique), are single-stranded DNAs with enzymatic activities. Compared to natural enzymes, DNAzymes are superior in terms of stability, ease of synthesis, modification and storage. As for some DNAzymes, they need specific metal ions as cofactors, and their enzymatic activities are highly dependent on the metal ion concentration. Their applications in metal ions detection have attracted more and more attention in these years. In this review, we summarized the researches on DNAzyme-based metal ion sensors. The focus is on the design of fluorescent sensors and colorimetric sensors.

Contents
1 Introduction
2 Pb2+ sensor
2.1 Pb2+ DNAzyme
2.2 DNAzyme-based fluorescent Pb2+ sensor
2.3 DNAzyme-based colorimetric Pb2+ sensor
3 Cu2+ sensor
3.1 Cu2+ DNAzyme
3.2 DNAzyme-based fluorescent Cu2+ sensor
3.3 DNAzyme-based colorimetric Cu2+ sensor
4 UO22+ sensor

4.1 DNAzyme-based fluorescent UO22+ sensor
4.2 DNAzyme-based colorimetric UO22+ sensor
5 Hg2+ sensor
5.1 DNAzyme-based fluorescent Hg2+ sensor
5.2 DNAzyme-based colorimetric Hg2+ sensor
6 Outlook

Key words: DNAzyme, metal ions, sensors, fluorescent sensors, colorimetric sensors

CLC Number: 

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