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Progress in Chemistry 2013, Vol. 25 Issue (04): 469-478 DOI: 10.7536/PC121136 Previous Articles   Next Articles

The Study of Biological Inorganic Chemistry Problemsin Translational Medicine

Zhang Jinchao*1, Hu Yi*2, Yu Siwang3, Gao Yuxi2, Zhang Haisong4   

  1. 1. Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 07100;
    2. CAS Key Laboratory of Nuclear Analytical Techniques, Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;
    3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijing 100191, China;
    4. Affiliated Hospital of Hebei University, Baoding 071000, China
  • Received: Revised: Online: Published:
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Translational medicine is an emerging concept in the fields of biomedical research and healthcare since twenty-first century. It is a two-way process from the basic research to clinical application with direct feedbacks in between. It is not a new subject, but emphasizes a concept. It stems from an unmet need in clinical medicine. At present, translational medical research is mainly involved in the following areas: cancer, cardiovascular diseases, metabolic disorders, psychiatric disorders, diseases of the locomotor system, genetic diseases, organ transplantation, tissue engineering, disease diagnosis, drug research and development, personalized therapy, stem cell research, animal model studies and immunology etc. This article reviews the bioinorganic chemistry problems involved in the disease diagnosis, tissue engineering, individual therapy, drug research and development and disease mechanisms. Finally, the development of this new area and important issues to be studied are outlooked.Contents
1 The bioinorganic chemistry problems in disease diagnosis
1.1 New diagnosis methods
1.2 Imaging technology
2 The bioinorganic chemistry problems in tissue engineering
3 The bioinorganic chemistry problems in individual therapy
4 The bioinorganic chemistry problems in drug research and development
4.1 From single-target drug design to systematic intervention
4.2 Emerging nanomedicine
5 The bioinorganic chemistry problems in molecular mechanisms of diseases
5.1 The relationship between metal homeostasis and neurodegenerative diseases
5.2 The relationship between oxygen (nitrogen) homeostasis and neurodegenerative diseases
6 Outlook

Key words: translational medicine, biological inorganic chemistry, disease diagnosis, individual therapy, tissue engineering, drug research and development, metal homeostasis, oxygen (nitrogen) homeostasis

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