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Progress in Chemistry 2013, Vol. 25 Issue (06): 975-989 DOI: 10.7536/PC120941 Previous Articles   Next Articles

• Review •

Functionalized Conjugated Polymers and Their Application in the Biological and/or Chemical Analysis

Cai Xiaohui1, Shi Lin1, Liu Xingfen1,2*, Huang Yanqin1,2, Fan Quli1,2, Huang Wei1,2,3,4*   

  1. 1. Institute of Advanced Materials(IAM), Nanjing University of Posts & Telecommunications, Nanjing 210046, China;
    2. Key Laboratory for Organic Electronics & Information Displays (KLOEID), Nanjing 210046, China;
    3. Jiangsu-Singapore Joint Research Center for Organic/Bio-Electronics & Information Displays, Nanjing 211816, China;
    4. Institute of Advanced Materials, Nanjing University of Technology, Nanjing 211816, China
  • Received: Revised: Online: Published:
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Conjugated polymers with large, delocalized molecular structure have been widely used in the field of organic electronics, biological and/or chemical sensing, diagnosis and bioimaging due to their unique optical absorption and emission characteristics. Conjugated polymers functionalized by special groups, such as glycosyl, biotin, carboxyl, amino acid, peptide, nucleic acid, antibody, amino, thiol and so on, have ability to recognize certain biomolecules or heavy metal ions. Here, we review the recent development of functionalized conjugated polymer and their application in the biological and/or chemical analysis on the basis of functional groups of different types. Methods for functionalization of conjugated polymers, the application in the detection of proteins, pathogens, Hg2+ and Pb2+, and future development of this area are also included. Contents
1 Introduction
2 Functionalization of conjugated polymers and their application in the biological and/or chemical analysis
2.1 Glycosyl functionalization
2.2 Biotin functionalization
2.3 Carboxyl functionalization
2.4 Functionalized with amino acid, peptide, nucleic acid and antibody
2.5 Functionalized with other groups (amino, thiol, and crown ether)
3 Summary and outlook

Key words: conjugated polymers, functionalization, biosensor, glycosylation, biotin

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