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Progress in Chemistry 2013, Vol. 25 Issue (04): 479-487 DOI: 10.7536/PC120631 Previous Articles   Next Articles

Selenoprotein M and Its Effects on Diseases

Chen Ping1,2, Jiang Liang2, Liu Qiong*2, Yang Silin3, Song Yun3, Ni Jiazuan2   

  1. 1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 13002;
    2. College of Life Sciences, Shenzhen University, Shenzhen 518060, China;
    3. Huaxin Bio-Pharmaceutical Co. Ltd, Jieshou 236500, China
  • Received: Revised: Online: Published:
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Selenoprotein M (SelM) was discovered in 2002 by bioinformatics analysis. SelM is located in the endoplasmic reticulum, containing a common redox motif cysteine-X-X-selenocysteine. SelM attracts great attention due to its high expression in brain and its potential roles in antioxidative defense, neuroprotective function and cytosolic calcium regulation. This paper reviews recent research progress in SelM, especially its biological function and its relation with diseases, together with the author's work on SelM. The prospect of SelM research is also discussed in this paper.

Contents
1 Introduction
2 The primary structure of SelM and its distribution
3 The spatial structure of SelM
4 The biological function of SelM
4.1 Antioxidative function
4.2 Interaction with metal ions
4.3 Calcium regulation
5 Relation between SelM and diseases
5.1 SelM and AD
5.2 SelM and reproduction and development
5.3 SelM and cancer prevention
6 Perspectives

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