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化学进展 2016, Vol. 28 Issue (6): 814-828 DOI: 10.7536/PC150917 前一篇   后一篇

• 综述与评论 •

鹅去氧胆酸及其衍生物的制备和应用

胡祥正1,2*, 王建敏1   

  1. 1. 天津科技大学食品工程与生物技术学院 天津 300457;
    2. 天津科技大学化工与材料学院 天津 300457
  • 收稿日期:2015-09-01 修回日期:2015-12-01 出版日期:2016-06-15 发布日期:2016-03-23
  • 通讯作者: 胡祥正 E-mail:huxzh@tust.edu.cn
  • 基金资助:
    天津市科技计划项目(No.14ZXCXSY00109, 14RCHZSY00159)资助
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Preparation and Application of Chenodeoxycholic Acid and Its Derivatives

Hu Xiangzheng1,2*, Wang Jianmin1   

  1. 1. College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China;
    2. College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, China
  • Received:2015-09-01 Revised:2015-12-01 Online:2016-06-15 Published:2016-03-23
  • Supported by:
    The work was supported by the Tianjin Science and Technology Project Funds (No. 14ZXCXSY00109, 14RCHZSY00159)
鹅去氧胆酸是天然的初级胆汁酸,是鸡、鸭和鹅等家禽胆汁中的主要有机成分,具有杀菌、抗炎和溶解胆结石等作用,是临床上治疗胆固醇结石的药物之一,也是合成临床上治疗胆结石疾病用量最大的药物熊去氧胆酸的原料。鹅去氧胆酸在医药方面的应用价值促使其制备方法逐步完善。近年来,关于鹅去氧胆酸衍生物的研究越来越多,相关研究也延伸到生物医药、分子识别和功能材料等多个领域,尤其在生物医药领域,鹅去氧胆酸衍生物显示出广阔的应用前景。本文系统地综述了鹅去氧胆酸的提取、合成与化学修饰方法,以及鹅去氧胆酸衍生物的合成、性质及应用,并展望了其发展前景。
关键词： 鹅去氧胆酸, 衍生物, 制备, 应用
Chenodeoxycholic acid as a natural primary bile acid is one of the main organic compounds in the bile of chicken, duck, goose and so on. It has the function of sterilization, anti-inflammatory and dissolution of gallstones. In clinical practice, chenodeoxycholic acid is the drug for treatment of cholesterol gallstones. Ursodeoxycholic acid is the largest amount of drug for the treatment of gallstone disease, and chenodeoxycholic acid is the raw material for the synthetic of ursodeoxycholic acid. The application value in medicine promotes the preparation methods of chenodeoxycholic acid gradually improved. In recent years, great progress has been made in the research of chenodeoxycholic acid derivatives. Study on application of chenodeoxycholic acid has been extended to biological medicine, molecular recognition, functional materials and other fields. In particular, chenodeoxycholic acid derivatives show broad application prospects in the field of biological medicine. This paper provides an overview of the methods of extraction, synthesis and chemical modification of chenodeoxycholic acid according to chenodeoxycholic acid related research progress. Meanwhile, synthesis methods, properties and applications of chenodeoxycholic acid derivatives are also reviewed. The development prospects of chenodeoxycholic acid and its derivatives is also prospected.

Contents
1 Introduction
2 The preparation of chenodeoxycholic acid
2.1 The extraction of chenodeoxycholic acid from bile
2.2 Chemical synthesis of chenodeoxycholic acid
3 The synthesis of chenodeoxycholic acid derivatives
3.1 Synthesis of derivatives modified at 6-position
3.2 Synthesis of derivatives modified at 3,7-position
3.3 Synthesis of derivatives modified at 24-position carboxyl
3.4 Synthesis of derivatives modified at other positions
4 Conclusion

Key words: chenodeoxycholic acid, derivatives, preparation, application

中图分类号: 

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