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化学进展 2023, Vol. 35 Issue (4): 560-576 DOI: 10.7536/PC221016 前一篇   后一篇

• 综述 •

含儿茶酚基团的湿态组织粘附水凝胶

陈一明, 李慧颖, 倪鹏, 方燕*(), 刘海清, 翁云翔*()   

  1. 福建师范大学化学与材料学院 福州 350007
  • 收稿日期:2022-10-26 修回日期:2023-01-11 出版日期:2023-04-24 发布日期:2023-02-16
  • 作者简介:

    刘海清 教授,博士生导师。2000年博士毕业于武汉大学,2000至2005年在美国加州大学戴维斯分校和康奈尔大学从事博士后研究,2013至2014年在爵硕大学从事访问学者研究。主要研究方向海洋生物高分子、天然高分子,止血纱布等。

    翁云翔 副教授,硕士生导师。2020年毕业于清华大学。主要面向人民健康需求的基础研究及应用问题,重点开展湿态生物组织粘附材料、止血材料的开发和应用。

  • 基金资助:
    国家自然科学基金(52103108); 国家自然科学基金(22175037); 福建省工信厅教育厅联合重点项目([2021]415-2021G02005); 福建省科技厅社会发展引导性项目(2020Y0020); 福建省中青年教师教育科研项目(JAT210047)
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Catechol Hydrogel as Wet Tissue Adhesive

Yiming Chen, Huiying Li, Peng Ni, Yan Fang(), Haiqing Liu, Yunxiang Weng()   

  1. College of Chemistry and Materials Science, Fujian Normal University,Fuzhou 350007, China
  • Received:2022-10-26 Revised:2023-01-11 Online:2023-04-24 Published:2023-02-16
  • Contact: *e-mail: haiqingliu@fjnu.edu.cn(Haiqing Liu); wengyx20@fjnu.edu.cn(Yunxiang Weng)
  • Supported by:
    National Natural Science Foundation of China(52103108); National Natural Science Foundation of China(22175037); Key Project for Advancing Science and Technology of Fujian Province([2021]415-2021G02005); Social Development of Instructive Program of Fujian Province(2020Y0020); Education and research project for young and middle-aged teachers of Fujian Province(JAT210047)

湿态粘附作用对于生命的孕育和发展具有重要意义。水凝胶是一类兼具固液特性的智能材料,组织粘附水凝胶因多功能性和生物相容性而被广泛应用于伤口闭合和修复、细胞工程、组织工程等领域。然而,湿态组织表面的水合层阻碍了组织粘附水凝胶与组织表面形成界面粘附键。面对这一挑战,受海洋贻贝足丝蛋白中DOPA的儿茶酚基团是水下粘附的关键结构的启发,含儿茶酚基团的湿态组织粘附水凝胶的研究引起了广泛关注。本综述介绍了贻贝足丝蛋白(Mfps)的结构及湿态粘附机理,并将儿茶酚衍生物分为天然Mfps或利用基因工程合成的Mfps、含儿茶酚基团的小分子化合物、儿茶酚基团改性的天然高分子以及含儿茶酚基团的合成功能高分子;随后,概述近十年含儿茶酚基团的湿态组织粘附水凝胶在组织创口修复材料、生物涂层材料、靶向型药物输送材料、生物电子设备材料的研究进展;文末,展望了此类水凝胶材料未来发展面临的机遇和挑战。

关键词： 贻贝足丝蛋白, 粘附机理, 儿茶酚衍生物, 湿态组织粘附, 水凝胶

Wet adhesion plays an important role in the gestation and development of life. The research shows that hydrogel is a kind of intelligent material with both solid and liquid properties. They have been widely used in such areas as wound closure and repair, cell engineering and tissue engineering, owing to their noteworthy versatility and bio-compatibility. However, the physiological environment is usually wet, and the hydration layer on wet tissue surface prevents hydrogel from forming interfacial adhesion bonds with tissue surface. Faced with this challenge, inspired by the fact that the catechol group of DOPA is critical group for the underwater adhesion of mussels, the structure and functional unit design of catechol hydrogel have attracted wide attention. This review introduces the structure and wet adhesion mechanism of mussel foot proteins (Mfps), and the main types of catechol derivatives are classified into natural Mfps or Mfps synthesized by genetic engineering, catechol small molecular compounds, natural polymers modified by catechol groups and synthesized functional polymers containing catechol groups. Nextly, the research progress of catechol hydrogel as wet tissue adhesive in the past decade is summarized, such as tissue wound repair materials, biological coating materials, targeted drug delivery materials and bioelectronic equipment materials. Finally, the opportunities and challenges of catechol hydrogel are prospected.

Key words: mussel foot proteins, adhesion mechanism, catechol, wet tissue-adhesion, hydrogel
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图1 Mfps的分布示意图
Fig.1 Distribution map of Mfps
图2 儿茶酚基团的作用机理图
Fig.2 Action mechanism diagram of catechol group
图3 含有多巴、赖氨酸、精氨酸和酪氨酸残基的自组装肽示意图,肽组装成纤维网络,并且这些残基的侧链具有局部纤维区域特异性
Fig.3 Schematic of self-assembling peptide showing sequential positions of DOPA, lysine, arginine and tyrosine residues. Peptides assemble into fibrillar networks displaying the side chains of these residues with local fibril regiospecificity
图4 (a)TA、(b)DA以及(c)UH的分子结构式
Fig.4 Molecular structure of(a) TA, (b) DA and (c) UH
图5 儿茶酚功能化多糖的结构式
Fig.5 Structures of catechol-functionalized polysaccharide
图6 儿茶酚功能化合成高分子的结构式
Fig.6 Structures of catechol-functionalized synthesized polymer
图7 Mfp-5模拟聚合物示意图
Fig.7 Schematic diagram of Mfp-5 mimetic polymer
图8 配位和共价糖多肽水凝胶(即R-凝胶和V-凝胶)的示意图;HRP:辣根过氧化物酶
Fig.8 Schematic diagram for coordinated and covalent glycopolyeptide hydrogels (i.e., R-Gels and V-Gels); HRP: Horseradish peroxidase
图9 左旋多巴、左旋多巴/PEI和DA的反应机理以及涂层形成过程的示意图
Fig.9 Schematic illustration of the reaction mechanisms and the coating formation processes of L-dopa, L-dopa/PEI, and DA
图10 (a)PAM-SDS-C18-DA预水凝胶表面的软甲状疏水粘附层示意图;(b)铁离子触发SDS胶束重组的示意图
Fig.10 (a) Constructing soft armour-like hydrophobic adhesive layer on the surface of PAM-SDS-C18-DA prehydrogel; (b) Schematic illustration of iron triggered recombination of SDS micelle
图11 多巴接枝的壳聚糖与粘蛋白的胺和半胱氨酸残基形成共价键示意图
Fig.11 DOPA-g-CS form covalent linkages with the amines and cysteine residues of mucin
图12 聚多巴胺胶囊中阿霉素的固定化及pH响应性释放
Fig.12 Immobilization and pH-Responsive Release of Dox from PDA Capsules
图13 水凝胶集成的生物粘附性超软脑机接口示意图
Fig.13 Schematic illustration of the hydrogel-integrated bio-adhesive ultrasoft BMI
图14 (a1)dsCD的合成和化学结构;(a2)Gel-UPy/dsCD水凝胶的合成及化学结构
Fig.14 (a1) Synthesis and chemical structures of dsCD; (a2) Synthesis and chemical structures of Gel-UPy/dsCD hydrogels
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