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Progress in Chemistry 2019, Vol. 31 Issue (5): 773-782 DOI: 10.7536/PC180910 Previous Articles   

Research on Bioactive Glass Nanospheres as Delivery

Qiwei Ying, Jianguo Liao**(), Minhang Wu, Zhihao Zhai, Xinru Liu   

  1. School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China
  • Received: Online: Published:
  • Contact: Jianguo Liao
  • About author:
    ** E-mail:
  • Supported by:
    National Natural Science Foundation of China(U1304820); Education Department of Henan Province Basic Research Program(19A430015); Education Department of Henan Province Basic Research Program(19B430004); Fundamental Research Funds for the Universities of Henan Province(NSFRF180311); Henan Province University Science and Technology Innovation Team(19IRTSTHN027)
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Bioactive glass nanosphere(BGN) contains elements such as silicon, calcium and phosphorus. It has controlled morphology and particle size, ordered mesoporous structure, high specific surface area and porosity, and due to the good biocompatibility and osteogenic activity, BGN has been widely used in bone repair and dental treatment. BGN can also be doped with different metal ions to enhance osteogenic, vascular, etc., or to provide antibacterial or bioimaging capabilities. At the same time, spherical shape, ordered mesoporous structures, nanoscale size and high specific surface facilitate the entry of drugs/biological-factors into cells, which gives BGN potential for high loading capacity and targeted therapeutic capabilities. However, since it is difficult to prepare monodisperse BGN with nanoscale particle size, and the agglomeration problem is common in nanoscale particles, the impact on the body is not completely clear. Therefore, BGN cannot be used as a drug carrier in clinical, and related research still needs to be further studied. In this paper, the research and application status of BGN preparation, loading capacity, biocompatibility and biological activity in recent years are reviewed, and its development directions are prospected.

Key words: bioactive glass nanospheres(BGN), biocompatibility, drug carriers, mesoporous structure
Fig. 1 Schematic illustration of the formation process of HMBGs[13]
Fig. 2 TEM images of HMBGs[12].(a)4 mM CTAB;(b)2 mM CTAB and (c)6 mM CTAB
Fig. 3 SEM micrograph(a) and TEM image(b) of mesoporous bioactive glass nanospheres with large pore[11]
Fig. 4 Schematic illustration of the synthesis process and mechanism of BGN[11]
Fig. 5 Schematic illustration of the structure-controlled formation of mesoporous bioactive glass nanoparticle(BGN) with different pore sizes by changing the co-solvent(ethyl ether or ethoxyethanol)[10]
Fig. 6 Typical bonds between the BGN and drug
Fig. 7 Distribution of drug molecules for the mesoporous channels in glass[52]
Fig. 8 LSC quantitative measurement of tissue distribution of 45Ca-BGN nanospheres[94]
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