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Progress in Chemistry 2020, Vol. 32 Issue (9): 1252-1263 DOI: 10.7536/PC200209 Previous Articles   Next Articles

• Review •

Application of Nanoparticles-Based Chemiluminescence in Diagnosis and Treatment of Inflammation and Tumor

Ding Jingjing1, Lili Huang1, Haiyan Xie1,**   

  1. 1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China
  • Received: Revised: Online: Published:
  • Contact: Haiyan Xie
  • Supported by:
    the Natural Science Foundation of China(21874011)
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Optical technology plays a vital role in the field of biomedicine. It not only enables visualization of physiological or pathological processes at the cellular and subcellular dimensions in living subjects, but also improves the specificity and sensitivity of disease treatment. However, ordinary optical technology faces many challenges, including relatively low tissue penetration depth, low signal-to-noise ratio, and autofluorescence of the tissue. To overcome these problems, many researchers have gradually begun to focus on self-luminous technologies, including chemiluminescence, bioluminescence, and Cherenkov luminescence. Among them, chemiluminescence(CL) is a kind of light radiation phenomenon, which is produced by chemical substances in the process of chemical reactions. It has many advantages, including high sensitivity, no need for external light source excitation, breaking through the limit of tissue penetration depth, and improving the signal-to-noise ratio. These characteristics provide new ideas for the further development of optical imaging and treatment technology. However, due to the hydrophobicity of the chemiluminescent substance and other problems, its application in the field of biomedicine has been limited. To solve these problems, researchers have begun to combine nanotechnology with chemiluminescence technology, which not only expands the application range of chemiluminescence, but also further promotes the diagnosis and treatment of diseases. On this basis, the article first analyzes the molecular mechanism of chemiluminescence, secondly summarizes the application of chemiluminescence in the diagnosis and treatment of inflammation and tumor, and discusses the problems encountered in practical applications and the future development direction.

Contents

1 Introduction

2 The molecular mechanisms of chemiluminescence

2.1 Direct chemiluminescence

2.2 Indirect chemiluminescence

3 Application of nanoparticles-based chemiluminescence in inflammation and tumor diagnosis

3.1 Nanoparticles-based luminol chemiluminescence imaging

3.2 Nanoparticles-based oxalate peroxide chemiluminescence imaging

4 Application of nanoparticles-based chemiluminescence in tumor treatment

4.1 Nanoparticles-based luminol luminescence-induced tumor treatment

4.2 Nanoparticles-based oxalate peroxide luminescence-induced tumor treatment

4.3 Combination of chemiluminescence-induced photodynamic therapy and other tumor therapies

5 Conclusion and outlook

Key words: chemiluminescence, luminol, oxalate peroxide, hydrogen peroxide, nanoparticles, imaging, therapy
Fig.1 Mechanism for luminol chemiluminescence[18~22]
Fig.2 (a) Formation of 1,2-dioxetanedione[26];(b) Schuster’s CIEEL mechanism on the 1,2-dioxetanedione[27,28]
Fig.3 Application of gold nanoparticles in enhancing luminous intensity[40]
Fig.4 (A) The spectrum of Luminol-R;(B) The tumor metastases imaging of Luminol-R nanoparticles[41];(C) Construction and luminescence mechanism of DiI-DiD nanobubbles;(D) The tumor imaging of DiI-DiD nanobubble[42]
Fig.5 (a) FPOC NPs and in vivo CL imaging of arthritis in the LPS induction model[46];(b) Construction of wavelength-tunable nanoparticles and in vivo imaging of arthritis[47]
Fig.6 Construction of SPN-NIR nanoparticles and the imaging of neuroinflammation and peritonitis[52]
Fig.7 (a) Fabrication process of the CSN and its application in intracellular oxidase-catalyzed biomarker detection;(b) Response of G-CSN-labeled cells for insulin sensitizer screening[53]
Fig.8 (a) Construction of the CLP and the mechanism of photodynamic therapy;(b) Tumor suppressive effect[64]
Fig.9 (a) Schematic representation of the mechanism of ROS generation for PDT and fluorescence imaging upon the addition of chemiluminescence substrates;(b) Normalized absorption spectra of m-THPC and HO-Pdots and emission spectra of HO-Pdots and the chemiluminescence of luminol;(c) Comparison of the absorbance change of ABDA by HO-Pdots with or without m-THPC doped as a function of irradiation time[65]
Fig.10 (a) Construction of the CL-induced y-CDs-Ce6 PDT system and the mechanism of photodynamic therapy;(b) Normalized absorption spectra of y-CDs and Ce6 and emission spectra of y-CDs and the luminol-H2O2-HRP CL system;(c) Tumor inhibition of mice after 20 days of treatments[66]
Fig.11 Construction of POCL and the principle of singlet oxygen production and the therapeutic effects [68]
Fig.12 The application of chemiluminescence in drug delivery[69]
Fig.13 Construction of Hb-NPs@liposome and the mechanism of photodynamic and chemotherapy combined therapy[70]
Fig.14 Construction of bionic nanoparticles and the principle of singlet oxygen production and the therapeutic effects in lung metastasis model [71]
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