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Progress in Chemistry 2007, Vol. 19 Issue (012): 1947-1954 Previous Articles   Next Articles

• Invited Article •

Biocatalysis in Drug Discovery and Development

Chen Yijun* Wu Xuri   

  1. (Laboratory pf Chemical Biology, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China)

  • Received: Revised: Online: Published:
  • Contact: Chen Yijun
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Due to the advantages including mild conditions, high catalytic efficiency, high stereoselectivity and regioselectivity and less byproducts, biocatalysis has been widely utilized and applied in drug discovery and development. Moreover, biocatlysts can be structurally changed and optimized through new technologies such as directed evolution, which could be better suited for biocatalytic processes. In this review, recent progress in the field of application of biocatalysis in drug discovery and development is briefly introduced and discussed.
Key words: biocatlysis, biocatalyst, metabolites, chiral drugs, drug discovery and development

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