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化学进展 2014, Vol. 26 Issue (05): 784-795 DOI: 10.7536/PC131124 前一篇   后一篇

• 综述与评论 •

深共融溶剂在有机合成中的应用

王爱玲1, 郑学良1,2, 赵壮志1,2, 李长平1, 郑学仿*1,2   

  1. 1. 大连大学环境与化学工程学院 大连 116622;
    2. 大连大学辽宁省生物有机化学重点实验室 大连 116622
  • 收稿日期:2013-11-01 修回日期:2013-12-01 出版日期:2014-05-15 发布日期:2014-03-13
  • 通讯作者: 郑学仿，e-mail：dlxfzheng@126.com E-mail:dlxfzheng@126.com
  • 基金资助:

    国家自然科学基金项目（No. 21271036）和大连市优秀青年科技人才基金项目（No. 2009J22DW038）资助

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Deep Eutectic Solvents to Organic Synthesis

Wang Ailing1, Zheng Xueliang1,2, Zhao Zhuangzhi1,2, Li Changping1, Zheng Xuefang*1,2   

  1. 1. College of Environment and Chemical Engineering, Dalian University, Dalian 116622;
    2. Liaoning Key Laboratory of Bio-Organic Chemistry, Dalian University, Dalian 116622, China
  • Received:2013-11-01 Revised:2013-12-01 Online:2014-05-15 Published:2014-03-13
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No. 21271036) and the Outstanding Young Talent Fund from the Dalian Science and Technology Bureau (No. 2009J22DW038).

深共融溶剂是一种新型绿色溶剂，与传统的有机溶剂相比，其具有低蒸气压、 不易燃、 稳定性好、 无毒性、 生物降解性、 可回收和廉价易得等优点。深共融溶剂作为新型溶剂，应用前景广泛。本文综述了近几年其作为新型的反应介质或催化剂用于传统的有机合成反应的最新研究成果，主要从卤代反应、Diels-Alder反应、Knoevenagel缩合、Henry反应、Perkin反应、Paal-Knorr反应和Biginelli反应等方面对其进行综述，最后展望了深共融溶剂在有机反应中的发展前景。

关键词： 绿色化学, 深共融溶剂, 有机合成, 应用

Deep eutectic solvents(DES) is a new type of environmentally green solvents. Compared with conventional organic solvents, DES have more advantages, such as negligible vapor pressure, non-flammability, good chemical and thermal stability, non-toxicity, biodegradability, recyclability and low price among others. As a new type of solvent, DES has an extremely extensive application prospect. The latest research results of DES is reviewed in this paper. DES as a novel solvent and catalyst was applied in the traditional organic synthesis reaction, mainly including Helogenation reaction, Diels-Alder reaction, Knoevenagel reaction, Henry reaction, Perkin reaction, Paal-Knorr reaction, Biginelli reaction. At last, we hope that DES has a good application prospect in the field of organic synthesis.

Contents
1 Introduction
2 DES in the replacement reaction
2.1 Alkylation of nitrogen
2.2 Alkylation of the alcohol
2.3 Friedel-Crafts alkylation reaction
2.4 Halogenation
2.5 Esterification
3 DES in addition reactions
3.1 Diels-Alder reaction
3.2 Henry reaction
3.3 Cycloaddition
4 DES in condensation reaction
4.1 Knoevenagel condensation
4.2 Perkin reaction
5 DES in the cyclization
5.1 Fischer indole synthesis
5.2 Paal-Knorr reaction
5.3 Biginelli reaction
6 DES in the elimination reactions
7 DES in rearrangement reactions
8 DES in reducing reactions
9 Conclusions and outlook

Key words: green chemistry, deep eutectic solvents, organic synthesis, application

中图分类号: 

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摘要

深共融溶剂在有机合成中的应用