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化学进展 2009, Vol. 21 Issue (0708): 1398-1407 前一篇   后一篇

• 综述与评论 •

双光子诱导产生单重态氧的三重态光敏剂的研究*

李红茹**|谢亭|胡女丹|杨刘峰|张胜涛|高放**   

  1. (重庆大学化学与化工学院  |重庆  |400044)
  • 收稿日期:2008-08-05 修回日期:2008-09-08 出版日期:2009-08-24 发布日期:2009-06-30
  • 通讯作者: 李红茹;高放 E-mail:fanggao1971@gmail.com; hongruli1972@gmail.com
  • 基金资助:

    教育部全国百篇优秀博士论文作者专项基金资助;国家自然科学基金;省级资助

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Two-Photon Triplet Photosensitizers for the Production of Singlet Oxygen

Li Hongru**; Xie Ting; Hu Nüdan; Yang Liufeng; Zhang Shengtao; Gao Fang**   

  1. (College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China)
  • Received:2008-08-05 Revised:2008-09-08 Online:2009-08-24 Published:2009-06-30
  • Contact: Li Hongru; Gao Fang E-mail:fanggao1971@gmail.com; hongruli1972@gmail.com

自2001年以来，双光子敏化产生单重态氧的三重态光敏剂的研究取得了一定的进展。双光子三重态光敏剂对肿瘤组织的近红外激光和红外激光的光动力治疗作用具有广阔的应用前景。本文重点分析了近些年已报道的双光子三重态光敏剂种类，如疏水性、水溶性等不同的敏化剂；介绍了可以根据分子的激发态性质、利用化学手段对双光子三重态敏化剂的性质以及光敏产生单重态氧的量子产率进行调控；概括了双光子三重态敏化剂的相对和绝对双光子横截面的测量方法；总结了双光子三重态敏化剂发展中面临的一些关键问题，并展望了双光子三重态敏化剂的发展方向。

关键词： 双光子, 三重态, 光敏剂, 单重态氧, 光动力治疗

Since 2001, some progress has been made on the development of two-photon triplet photosensitizers which can be employed for the production of singlet oxygen. These sensitizers have great application potential as photo-dynamic therapy pharmaceutical for the treatment of tumor tissue under near-IR and IR laser. This paper emphasizes the analysis of category of the two-photon triplet sensitizers which have been developed in recent years, such as hydrophobic and water-soluble sensitizers. This paper also describes how to control the properties of two-photon sensitizers and quantum yields of singlet oxygen of sensitizers with chemical approach based on the properties of the excited states of the sensitizers. The measurement of of relative and absolute two-photon absorption cross sections of the sensitizers is generalized. Some significant problems on the development of two-photon triplet sensitizers are summarized. Furthermore, the prospectives on the research of the two-photon triplet sensitizers are discussed as well in this paper.

Contents
1 Introduction
2 Types and synthesis of the two-photon sensitizers
2.1 Hydrophobic two-photon triplet sensitizers
2.2 Water-soluble two-photon triplet sensitizers
2.3 Routine single oxygen sensitizers as two-photon triplet sensitizers
2.4 Two-photon triplet sensitizers prepared with FRET method
2.5 Organometallic compounds as two-photon sensitizers
3 Detection of two-photon cross sections of two-photon sensitizers
4 Problems

Key words: two-photon, triplet state, photosensitizer, singlet oxygen, photo-dynamic therapy

中图分类号: 

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