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化学进展 2013, Vol. 25 Issue (04): 555-562 DOI: 10.7536/PC121056 前一篇   后一篇

• 金属与核酸 •

细胞研究中的金属配合物-核酸相互作用

杨婵丽, 董雄伟, 江南, 章丹, 刘长林*   

  1. 华中师范大学化学学院农药与化学生物学教育部重点实验室 武汉 430079
  • 收稿日期:2012-10-01 修回日期:2012-11-01 出版日期:2013-04-24 发布日期:2013-04-09
  • 通讯作者: 刘长林 E-mail:liuchl@mail.ccnu.edu.cn
  • 基金资助:

    国家自然科学基金项目(No. 20971049,21072074)资助

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Introduction of Metal Complex-Nucleic Acid Interactions into Cells

Yang Chanli, Dong Xiongwei, Jiang Nan, Zhang Dan, Liu Changlin*   

  1. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
  • Received:2012-10-01 Revised:2012-11-01 Online:2013-04-24 Published:2013-04-09

金属配合物与核酸相互作用的探讨对新型抗癌金属药物的设计、核酸结构的特异识别和核酸水解断裂的研究一直起着巨大的推动作用。不仅如此,配合物与核酸的相互作用已被引入细胞生物学研究中。本文利用一些典型的研究结果,对配合物与核酸相互作用应用于胞内DNA定位成像,对胞内信号转导和表观遗传的影响,以及金属配合物作为非病毒基因载体进行了总结。

关键词： 金属配合物, 细胞成像, 表观遗传, 信号转导, 非病毒基因载体

The exploration on metal complex-nucleic acid interactions plays key roles not only in rational design of both new metal-based anticancer drugs and effective hydrolytic cleaving agents of nucleic acids, but also in development of specific recognition probes of nucleic acid structures. Currently, the metal complex-nucleic acid interactions are being introduced into cell biological studies. For example, the intracellular localization imaging methods of nuclear and mitochondrial DNAs are being developed based on the DNA binding of ruthenium(Ⅱ) complexes. The effects of metal complex binding to nucleic acids on intracellular signal transduction and epigenetic inheritance have attracted a good deal of attention. The metal complexes that may act as nonviral nucleic acid carriers are being designed on the basis of their ability to condense nucleic acids. We review the important advances in investigation on the intracellular metal complex-nucleic acid interactions by utilization of typical cases.

Contents
1 Introduction
2 Metal complexes used as localization imaging agents of nuclear and mitochondrial DNAs
3 Effects of nucleic acid-metal complex interactions on intracellular signal transduction
4 Nucleic acid-metal complex interactions and epigenetic inheritance
5 Metal complexes used as nonviral nucleic acid carriers
6 Outlook

Key words: metal complexes, cell imaging, epigenetic inheritance, signal transduction, non-viral gene vectors

中图分类号: 

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