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化学进展 2015, Vol. 27 Issue (6): 755-762 DOI: 10.7536/PC150227 前一篇   后一篇

• 综述与评论 •

咔咯及其金属配合物与DNA的作用和抗肿瘤活性

王家敏1, 史蕾2*, 刘海洋1*   

  1. 1. 华南理工大学化学系 广州 510640;
    2. 广东第二师范学院化学系 广州 510303
  • 收稿日期:2015-02-01 修回日期:2015-03-01 出版日期:2015-06-15 发布日期:2015-03-25
  • 通讯作者: 史蕾, 刘海洋 E-mail:shil@gdei.edu.cn;chhyliu@scut.edu.cn
  • 基金资助:
    国家自然科学基金项目(No.21171057,21371059)和广东省自然科学基金(No.S2012040006270)资助
下载PDF ( 1959 ) 引用
导出 被引次数 ( 13 | 2 )

The Interaction of Corrole and Its Metal Complex with DNA and Their Anti-Tumor Activity

Wang Jiamin1, Shi Lei2*, Liu Haiyang1*   

  1. 1. Department of Chemistry, South China University of Technology, Guangzhou 510640, China;
    2. Department of Chemistry, Guangdong University of Education, Guangzhou 510303, China
  • Received:2015-02-01 Revised:2015-03-01 Online:2015-06-15 Published:2015-03-25
  • Contact: 10.7536/PC150227 E-mail:shil@gdei.edu.cn;chhyliu@scut.edu.cn
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21171057, 21371059) and the Guangdong Natural Science Foundation, China (No. S2012040006270).
咔咯及其金属配合物与DNA相互作用和它们的抗肿瘤活性研究已成为咔咯大环化学前沿课题之一。本文综述了咔咯及其金属配合物与DNA相互作用和关于这类化合物在抗肿瘤方面的研究进展,系统介绍了咔咯及其金属配合物与DNA结合模式、在氧化剂存在或光照条件下的核酸酶活性、与G-四链体DNA相互作用以及这类化合物抗肿瘤活性。
关键词： 咔咯, 金属配合物, DNA, 抗肿瘤活性
Study on the interaction of corrole and its metal complex with DNA and their anti-tumor activity has become one of the hot topics of corrole chemistry. This review covers the progress on the study of the interaction of corrole and its metal complex with DNA and their anti-tumor activity. The binding mode of corrole or its metal complex with DNA, chemical nuclease activity of corrole and its metal complex in the presence of oxidants or under irradiation, the interaction of corrole and its metal complex with G-quadruplex DNA and their anti-tumor activity are introduced systematically.

Contents
1 Introduction
2 Binding modes between corrole or its metal complex and DNA
3 Nuclease activity of corrole and its metal complex
3.1 Oxidative DNA cleavage mediated by metal corrole
3.2 Photocleavage of DNA by corrole and its metal complex
4 Interaction between G-quadruplex DNA and corrole or its metal complex
5 Anti-tumor activity of corrole and its metal complex
6 Conclusion

Key words: corrole, metal complex, DNA, anti-tumor activity

中图分类号: 

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