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化学进展 2009, Vol. 21 Issue (09): 1939-1944 前一篇   后一篇

• 综述与评论 •

生物酶法制备1, 3-甘油二酯

段章群|杜伟*|刘德华*   

  1. (清华大学化工系应用化学研究所   |北京 100084)
  • 收稿日期:2008-09-21 修回日期:2008-12-10 出版日期:2009-09-24 发布日期:2009-09-15
  • 通讯作者: 杜伟;刘德华 E-mail:duwei@tsinghua.edu.cn; dhliu@tsinghua.edu.cn
  • 基金资助:

    无

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Enzymatic Approach for 1, 3-Diacylglycerol Preparation

Duan Zhangqun|Du Wei*|Liu Dehua*   

  1. (Institute of Applied Chemistry, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China)
  • Received:2008-09-21 Revised:2008-12-10 Online:2009-09-24 Published:2009-09-15
  • Contact: Du Wei; Liu Dehua E-mail:duwei@tsinghua.edu.cn; dhliu@tsinghua.edu.cn

近年来的研究表明，食用含有1,3-甘油二酯（1,3-DAG）的油脂可以降低脂肪积累、防止体重增加。但是天然存在的1,3-DAG很少，所以1,3-DAG的制备尤显重要。相对于化学法，生物酶法合成1,3-DAG具有反应条件温和、环境友好、产品质量好等优点，故近年来利用酶法合成1,3-DAG越来越受到关注。本文综述了国内外生物酶法制备1,3-DAG的相关研究进展，并指出降低酶的生产成本、延长酶的使用寿命等措施有助于促进生物酶法工业化生产1,3-DAG。

关键词： 1,3-甘油二酯, 脂肪酶, 酯化反应, 转酯化反应

It has been shown recently that consumption of 1,3-Diacylglycerol(1,3-DAG) oil has beneficial effects on the suppressing the accumulation of body fat and preventing the increase of body weight. However, because of the minor content of 1,3-DAG in natural form, the synthesis of 1,3-DAG has become more significant. Chemical methods and enzymatic approach can be used for 1,3-DAG preparation. By comparison, there are many advantages associated with enzymatic approach: the reaction can be carried out under mild conditions, the process is environmentally friendly and high quality product can be achieved. Therefore, more and more attention have been paid to the enzymatic method for 1,3-DAG production in recent years. This review covers the aspects of enzyme-mediated catalysis for 1,3-DAG, and also suggests that reducing the cost and prolonging the lifetime of the enzyme can promote enzyme-mediated production of 1,3-DAG on industrial scale.

Contents
1 Introduction
2 Lipases for 1,3-DAG preparation
3 Methods for 1,3-DAG preparation
3.1 Esterification
3.2 Partial hydrolysis
3.3 Partial alcoholysis
3.4 Glycerolysis
3.5 Hydrolysis or alcoholysis followed by esterification
3.6 Other methods
4 Enzyme reactors for 1,3-DAG production
5 Conclusion and prospects

Key words: 1,3-DAG, lipases, esterfication, transesterification

中图分类号: 

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生物酶法制备1, 3-甘油二酯