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化学进展 2011, Vol. 23 Issue (9): 1959-1972 前一篇   后一篇

• 综述与评论 •

抗氧化剂活性的电子顺磁共振(EPR)研究

蔡余1, 王永健2, 王健1, 宋婵1, 于奡1*   

  1. 1. 南开大学化学学院中心实验室 天津 300071;
    2. 南开大学生命科学学院 生物活性材料教育部重点实验室 天津 300071
  • 收稿日期:2010-12-01 修回日期:2011-01-01 出版日期:2011-09-24 发布日期:2011-09-02
  • 通讯作者: 于奡 E-mail:esr@nankai.edu.cn
  • 基金资助:

    国家重点基础研究发展计划(863)项目(No.2011CB606202)资助

下载PDF ( 1625 ) 引用
导出 被引次数 ( 15 | 2 )

A Review of Antioxidant Activity Studies Using Electron Paramagnetic Resonance Methods

Cai Yu1, Wang Yongjian2, Wang Jian1, Song Chan1, Yu Ao1*   

  1. 1. Central Laboratory, College of Chemistry, Nankai University, Tianjin 300071, China;
    2. Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
  • Received:2010-12-01 Revised:2011-01-01 Online:2011-09-24 Published:2011-09-02

抗氧化剂在化工、食品以及生命科学等领域具有重要的作用,近年来更是由于其在解决与人类健康相关问题方面所起到的重要作用而受到广泛重视。本综述较为详细地介绍了利用电子顺磁共振(EPR)技术测定抗氧化剂活性的原理和方法,系统总结了近年来在天然抗氧化剂以及合成抗氧化剂化学活性方面的EPR研究最新进展,特别是定量测定表征抗氧化活性参数的EPR方法,以及影响抗氧化剂活性的取代基效应、杂原子效应、溶剂效应和抗氧化机理等诸多方面的EPR研究。

关键词： 电子顺磁共振(EPR), 电子自旋共振(ESR), 抗氧化剂活性

Antioxidants play a vital role in many fields, such as chemical engineering, food industry and life sciences, and are attracted much attention in recent years because of their beneficial influence on human health. In this paper, the measurement principles and methods for the determination of antioxidant activity by electron paramagnetic resonance (EPR) technique are introduced briefly. Progress in the EPR studies on antioxidant activity of natural and synthetic antioxidants in the last two decades is reviewed in detail, especially on the EPR indexes which characterize the antioxidant activity quantitatively, and the EPR application on the effects (substituent effect, heteroatomic effect, and solvent effect) which influence the antioxidant activity and the antioxidant mechanism.

Contents
1 Introduction
2 Theoretical aspects of EPR
3 Indexes and their determination of antioxidant activity by EPR
3.1 Kinetic mechanism of lipid peroxidation using EPR
3.2 The determination of A—H bond dissociation enthalpies BDE(A—H)
3.3 The determination of stoichiometric coefficient n and inhibition rate constant of peroxidation kinh
4 Application of EPR spectrometer on the studies of antioxidant activity
4.1 Natural antioxidants
4.2 Artificial antioxidants
5 Conclusions and Outlook

 

Key words: electron paramagnetic resonance (EPR), electron spin resonance (ESR), antioxidant activity

中图分类号: 

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