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化学进展 2009, Vol. 21 Issue (09): 1905-1921 前一篇   后一篇

• 综述与评论 •

纳米技术在毛细管电泳和微流控芯片电泳生物大分子分离中的应用*

耿利娜1;姜萍1;徐建栋1;车宝泉2;屈锋1;邓玉林1**   

  1. (1.北京理工大学生命科学与技术学院 |北京100081|2.北京市药品检验所 |北京100035)
  • 收稿日期:2008-09-19 修回日期:2008-12-30 出版日期:2009-09-24 发布日期:2009-09-15
  • 通讯作者: 邓玉林 E-mail:deng@bit.edu.cn
  • 基金资助:

    中德中心（GZ364）;国家自然科学基金

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Applications of Nanotechnology in Capillary Electrophoresis and Microfluidic Chip Electrophoresis Biomolecular Separations

Geng Lina1 ; |Jiang Ping1 ; |Xu Jiandong1 ; |Che Baoquan2 ; |Qu Feng1 ; |Deng Yulin1**   

  1. (1.School of Life Science and Technology| Beijing Institute of Technology| Beijing 100081, China|2. Beijing Institute for Drug Control| Beijing 100035| China)
  • Received:2008-09-19 Revised:2008-12-30 Online:2009-09-24 Published:2009-09-15
  • Contact: Deng Yulin E-mail:deng@bit.edu.cn

在分离领域，纳米技术主要以两种形式改善分离效果，一种是利用金、二氧化硅、聚合物、金属氧化物和碳纳米管等纳米材料，二是通过微机电加工、化学方法或者自组装技术构筑纳米障碍物和纳通道等纳米结构。本文对两种不同形式的纳米技术在毛细管电泳和微流控芯片电泳生物分离中的应用进行了综述。并对该领域未来的发展进行了展望。

关键词： 纳米材料, 纳米结构, 毛细管电泳, 微流控芯片电泳, 生物大分子分离

In this paper, the applications of nanotechnology in capillary electrophoresis and microfuidic chip biomolecular are reviewed. The nanotechnology is used to improve seperation effect by the nanomaterials of gold, silica, polymer, metal oxide and carbon nanotube, and the nanostructures including nanopillars and nanochannels, prepared by microelectromechanical(MEMS) technologies, chemical synthesis or self-assembly. The development of this field is also proposed.

Contents
1 Introduction
2 The applications of nanomaterials in capillary electrophoresis and chip electrophoresis
2.1 The application methods of nanomaterials in capillary electrophoresis
2.2 Applications of different kinds of nanomaterials in capillary electrophoresis
2.3 The applications of nanomaterials in chip bioelectrophoresis separation
3 The microfluidic chip electrophoresis seperation based on the construction of 3D-nanostructure
3.1 The sieving separations based on size differences
3.2 Separations based on entropic difference
3.3 Anisotropic separation
3.4 Brownian diffusion separation
3.5 Application of nanotechnologies in chip chromatography and chip electrochromatography
3.6 Techniques of nanochannels and nanofluidics
4 Conclusion and perspectives

Key words: nanomaterials, nanostructures, capillary electrophoresis, microfluidic chip electrophoresis, biomolecular separation

中图分类号: 

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